World's Best Scientists 2026 revealed!
Makoto Mark Taketo

Makoto Mark Taketo

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Biology and Biochemistry
Japan
2026
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Medicine
Japan
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
144
Citations
68768
World Ranking
232
National Ranking
6

Medicine

D-Index
143
Citations
68478
World Ranking
1521
National Ranking
29

Makoto Mark Taketo publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Makoto Mark Taketo sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 488 publications — 94th percentile

94% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Makoto Mark Taketo D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Makoto Mark Taketo sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 144 D-Index — 99th percentile

99% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Medicine in Japan Leader Award

Overview

Makoto Mark Taketo is affiliated with Kyoto University in Japan and contributes extensively to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their research spans various subfields including Molecular Biology, Oncology, Immunology, Surgery, and Cell Biology.

The scientist has a significant publication record with research frequently appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cancer Science, Cancer Research, and Oncogene.

Taketo's work addresses multiple main topics within the life sciences, notably Wnt/β-catenin signaling in development and cancer, Cancer Cells and Metastasis, Cancer, Hypoxia, and Metabolism, Fibroblast Growth Factor Research, Cancer-related gene regulation, Hair Growth and Disorders, and Epigenetics and DNA Methylation.

Recent papers include the following:

  • Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection (2021, Immunity)
  • Dedifferentiation maintains melanocyte stem cells in a dynamic niche (2023, Nature)
  • Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer (2020, Proceedings of the National Academy of Sciences)
  • Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation (2020, Cell Reports)
  • Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate (2022, Nature Communications)

They collaborate regularly with a number of researchers, including Hiroyuki Miyoshi, Yoshiharu Sakai, Kenji Kawada, Kazutaka Obama, and Teruaki Fujishita, with multiple joint publications documented.

Best Publications

  • Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

    Masanobu Oshima;Joseph E Dinchuk;Stacia L Kargman;Hiroko Oshima

  • Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene

    Naomoto Harada;Yoshitaka Tamai;Tomo O. Ishikawa;Brian Sauer;Brian Sauer

  • Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

    Theo P. Hill;Daniela Später;Makoto M. Taketo;Walter Birchmeier

  • Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

    Sarah Schwitalla;Alexander A. Fingerle;Patrizia Cammareri;Tim Nebelsiek

  • Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part II)

    Makoto M. Taketo

  • Interactions between Sox9 and β-catenin control chondrocyte differentiation

    Haruhiko Akiyama;Jon P. Lyons;Yuko Mori-Akiyama;Xiaohong Yang

  • Subtypes of medulloblastoma have distinct developmental origins

    Paul Gibson;Yiai Tong;Giles Robinson;Margaret C. Thompson

  • Wnt/β-catenin signaling controls development of the blood–brain barrier

    Stefan Liebner;Monica Corada;Thorsten Bangsow;Jane Babbage

  • TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis.

    Masanobu Oshima;Hiroko Oshima;Makoto M. Taketo

  • Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

    Satoshi Yamazaki;Hideo Ema;Göran Karlsson;Tomoyuki Yamaguchi

  • Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene

    Jiying Sun;Jiying Sun;Hideto Hoshino;Hideto Hoshino;Kazuaki Takaku;Osamu Nakajima

  • Wnt signalling induces maturation of Paneth cells in intestinal crypts

    Johan H. van Es;Philippe Jay;Alex Gregorieff;Marielle E. van Gijn

  • INTESTINAL TUMORIGENESIS IN COMPOUND MUTANT MICE OF BOTH DPC4 (SMAD4) AND APC GENES

    Kazuaki Takaku;Masanobu Oshima;Hiroyuki Miyoshi;Minoru Matsui

  • Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

    Masahiro Sonoshita;Kazuaki Takaku;Kazuaki Takaku;Nobuya Sasaki;Yukihiko Sugimoto

  • FVB/N: an inbred mouse strain preferable for transgenic analyses.

    M Taketo;A C Schroeder;L E Mobraaten;K B Gunning

  • β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

    Dietmar Zechner;Yasuyuki Fujita;Jörg Hülsken;Thomas Müller

  • Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

    Nigel Turner;Jing Ya Li;Alison Gosby;Sabrina W.C. To

  • Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene

    Minoru Matsui;Minoru Matsui;Masanobu Oshima;Hiroko Oshima;Kazuaki Takaku

  • Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

    Masanobu Oshima;Hiroko Oshima;Kyoko Kitagawa;Masahiko Kobayashi

  • HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

    Feng Ye;Feng Ye;Ying Chen;Thaonguyen Hoang;Rusty L. Montgomery

Frequent Co-Authors

Yoshiharu Sakai
Yoshiharu Sakai Kyoto University
Walter Birchmeier
Walter Birchmeier Max Delbrück Center for Molecular Medicine
Toshiya Manabe
Toshiya Manabe University of Tokyo
Sarah E. Millar
Sarah E. Millar University of Pennsylvania
Tsutomu Chiba
Tsutomu Chiba Kyoto University
Shuh Narumiya
Shuh Narumiya Kyoto University
Andreas Kispert
Andreas Kispert Hannover Medical School
Florian R. Greten
Florian R. Greten Goethe University Frankfurt
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Angel Pazos
Angel Pazos University of Cantabria

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