World's Best Scientists 2026 revealed!
Makoto Mark Taketo

Makoto Mark Taketo

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Biology and Biochemistry
Japan
2026
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Medicine
Japan
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
144
Citations
68768
World Ranking
232
National Ranking
6

Medicine

D-Index
143
Citations
68478
World Ranking
1521
National Ranking
29

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Medicine in Japan Leader Award

Overview

Makoto Mark Taketo is affiliated with Kyoto University in Japan and contributes extensively to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their research spans various subfields including Molecular Biology, Oncology, Immunology, Surgery, and Cell Biology.

The scientist has a significant publication record with research frequently appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cancer Science, Cancer Research, and Oncogene.

Taketo's work addresses multiple main topics within the life sciences, notably Wnt/β-catenin signaling in development and cancer, Cancer Cells and Metastasis, Cancer, Hypoxia, and Metabolism, Fibroblast Growth Factor Research, Cancer-related gene regulation, Hair Growth and Disorders, and Epigenetics and DNA Methylation.

Recent papers include the following:

  • Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection (2021, Immunity)
  • Dedifferentiation maintains melanocyte stem cells in a dynamic niche (2023, Nature)
  • Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer (2020, Proceedings of the National Academy of Sciences)
  • Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation (2020, Cell Reports)
  • Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate (2022, Nature Communications)

They collaborate regularly with a number of researchers, including Hiroyuki Miyoshi, Yoshiharu Sakai, Kenji Kawada, Kazutaka Obama, and Teruaki Fujishita, with multiple joint publications documented.

Best Publications

  • Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

    Masanobu Oshima;Joseph E Dinchuk;Stacia L Kargman;Hiroko Oshima

  • Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene

    Naomoto Harada;Yoshitaka Tamai;Tomo O. Ishikawa;Brian Sauer;Brian Sauer

  • Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

    Theo P. Hill;Daniela Später;Makoto M. Taketo;Walter Birchmeier

  • Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

    Sarah Schwitalla;Alexander A. Fingerle;Patrizia Cammareri;Tim Nebelsiek

  • Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part II)

    Makoto M. Taketo

  • Interactions between Sox9 and β-catenin control chondrocyte differentiation

    Haruhiko Akiyama;Jon P. Lyons;Yuko Mori-Akiyama;Xiaohong Yang

  • Subtypes of medulloblastoma have distinct developmental origins

    Paul Gibson;Yiai Tong;Giles Robinson;Margaret C. Thompson

  • Wnt/β-catenin signaling controls development of the blood–brain barrier

    Stefan Liebner;Monica Corada;Thorsten Bangsow;Jane Babbage

  • TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis.

    Masanobu Oshima;Hiroko Oshima;Makoto M. Taketo

  • Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

    Satoshi Yamazaki;Hideo Ema;Göran Karlsson;Tomoyuki Yamaguchi

  • Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene

    Jiying Sun;Jiying Sun;Hideto Hoshino;Hideto Hoshino;Kazuaki Takaku;Osamu Nakajima

  • Wnt signalling induces maturation of Paneth cells in intestinal crypts

    Johan H. van Es;Philippe Jay;Alex Gregorieff;Marielle E. van Gijn

  • INTESTINAL TUMORIGENESIS IN COMPOUND MUTANT MICE OF BOTH DPC4 (SMAD4) AND APC GENES

    Kazuaki Takaku;Masanobu Oshima;Hiroyuki Miyoshi;Minoru Matsui

  • Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

    Masahiro Sonoshita;Kazuaki Takaku;Kazuaki Takaku;Nobuya Sasaki;Yukihiko Sugimoto

  • FVB/N: an inbred mouse strain preferable for transgenic analyses.

    M Taketo;A C Schroeder;L E Mobraaten;K B Gunning

  • β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

    Dietmar Zechner;Yasuyuki Fujita;Jörg Hülsken;Thomas Müller

  • Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

    Nigel Turner;Jing Ya Li;Alison Gosby;Sabrina W.C. To

  • Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene

    Minoru Matsui;Minoru Matsui;Masanobu Oshima;Hiroko Oshima;Kazuaki Takaku

  • Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

    Masanobu Oshima;Hiroko Oshima;Kyoko Kitagawa;Masahiko Kobayashi

  • HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

    Feng Ye;Feng Ye;Ying Chen;Thaonguyen Hoang;Rusty L. Montgomery

Frequent Co-Authors

Yoshiharu Sakai
Yoshiharu Sakai Kyoto University
Walter Birchmeier
Walter Birchmeier Max Delbrück Center for Molecular Medicine
Toshiya Manabe
Toshiya Manabe University of Tokyo
Sarah E. Millar
Sarah E. Millar University of Pennsylvania
Tsutomu Chiba
Tsutomu Chiba Kyoto University
Shuh Narumiya
Shuh Narumiya Kyoto University
Andreas Kispert
Andreas Kispert Hannover Medical School
Florian R. Greten
Florian R. Greten Goethe University Frankfurt
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Angel Pazos
Angel Pazos University of Cantabria

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