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Genetics

D-Index
75
Citations
20161
World Ranking
1904
National Ranking
74

Molecular Biology

D-Index
75
Citations
20161
World Ranking
1193
National Ranking
97

Overview

Yumiko Saga is affiliated with the National Institute of Genetics in Japan. Their research primarily falls within the broad field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology and Genetics as well as related areas such as Cellular and Molecular Neuroscience, Public Health, Environmental and Occupational Health, and Developmental Neuroscience.

The main topics of their work include:

  • RNA Research and Splicing
  • CRISPR and Genetic Engineering
  • Developmental Biology and Gene Regulation
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Reproductive Biology and Fertility
  • Protein Degradation and Inhibitors
  • Ubiquitin and Proteasome Pathways

Their recent papers demonstrate involvement in diverse molecular biology topics. Notable publications include:

  • The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice, 2020, Nature Communications
  • Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice, 2021, Development
  • NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells, 2021, iScience
  • Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders: Human genetic and experimental evidences, 2023, European Journal of Medical Genetics
  • Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence, 2020, PLoS ONE

Their frequent co-authors reflect ongoing collaborations with researchers such as Rieko Ajima, Masafumi Muraoka, Hajime Okada, Makoto Kiso, and Takamasa Hirano. This suggests an extensive network of scientific partnerships within their research community.

Yumiko Saga's publications are commonly found in venues including bioRxiv (Cold Spring Harbor Laboratory), Development, Development Growth & Differentiation, iScience, and PLoS Genetics. These journals are well recognized within molecular biology and genetics disciplines, indicating their active contribution to these scientific communities.

Best Publications

  • MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube.

    Yumiko Saga;Sachiko Miyagawa-Tomita;Atsuya Takagi;Satoshi Kitajima

  • Mice develop normally without tenascin.

    Y Saga;T Yagi;Y Ikawa;T Sakakura

  • Conserved Role of nanos Proteins in Germ Cell Development

    Masayuki Tsuda;Yumiko Sasaoka;Makoto Kiso;Kuniya Abe

  • A Novel ES Cell Line, TT2, with High Germline-Differentiating Potency

    T. Yagi;T. Tokunaga;Y. Furuta;S. Nada

  • Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors

    Toyoaki Natsume;Tomomi Kiyomitsu;Tomomi Kiyomitsu;Yumiko Saga;Yumiko Saga;Masato T. Kanemaki;Masato T. Kanemaki

  • An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation

    Owen W.J. Prall;Mary K. Menon;Mark J. Solloway;Yusuke Watanabe

  • Periostin is essential for cardiac healing after acute myocardial infarction

    Masashi Shimazaki;Kazuto Nakamura;Isao Kii;Takeshi Kashima

  • Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice.

    Yoshiyuki Seki;Masashi Yamaji;Yukihiro Yabuta;Mitsue Sano

  • Cell lineage in mammalian craniofacial mesenchyme.

    Toshiyuki Yoshida;Philaiporn Vivatbutsiri;Gillian Morriss-Kay;Yumiko Saga

  • Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.

    Yumiko Saga;Naomi Hata;Haruhiko Koseki;Makoto M. Taketo

  • Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens.

    M Streuli;L R Hall;Y Saga;S F Schlossman

  • The making of the somite: molecular events in vertebrate segmentation

    Yumiko Saga;Hiroyuki Takeda;Hiroyuki Takeda

  • MesP1 and MesP2 are essential for the development of cardiac mesoderm

    Satoshi Kitajima;Atsuya Takagi;Tohru Inoue;Yumiko Saga

  • Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis

    Alexandra Klaus;Yumiko Saga;Makoto M. Taketo;Eldad Tzahor

  • Nanos2 suppresses meiosis and promotes male germ cell differentiation

    Atsushi Suzuki;Yumiko Saga

  • Mesp1 Expression Is the Earliest Sign of Cardiovascular Development

    Yumiko Saga;Satoshi Kitajima;Sachiko Miyagawa-Tomita

  • The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice.

    Aisha Yesbolatova;Aisha Yesbolatova;Yuichiro Saito;Naomi Kitamoto;Hatsune Makino-Itou

  • The RNA-Binding Protein NANOS2 Is Required to Maintain Murine Spermatogonial Stem Cells

    Aiko Sada;Atsushi Suzuki;Hitomi Suzuki;Yumiko Saga;Yumiko Saga

  • Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites.

    Sawada A;Fritz A;Jiang Yj;Yamamoto A

  • Mesp2 initiates somite segmentation through the Notch signalling pathway

    Yu Takahashi;Ken-ichi Koizumi;Atsuya Takagi;Satoshi Kitajima

Frequent Co-Authors

Hiroyuki Takeda
Hiroyuki Takeda University of Tokyo
Haruhiko Koseki
Haruhiko Koseki RIKEN Center for Integrative Medical Sciences
Raphael Kopan
Raphael Kopan Cincinnati Children's Hospital Medical Center
Akira Kudo
Akira Kudo Tokyo Institute of Technology
Hiroshi Hamada
Hiroshi Hamada RIKEN Center for Biosystems Dynamics Research
Randy L. Johnson
Randy L. Johnson The University of Texas MD Anderson Cancer Center
Satoru Matsuda
Satoru Matsuda Keio University
Masato T. Kanemaki
Masato T. Kanemaki National Institute of Genetics
Hideyuki Okano
Hideyuki Okano Keio University
Sally L. Dunwoodie
Sally L. Dunwoodie Victor Chang Cardiac Research Institute

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