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Molecular Biology

D-Index
65
Citations
20275
World Ranking
1651
National Ranking
138

Overview

Shinji Takada is affiliated with the National Institutes of Natural Sciences in Japan and is active in research within the field of Biochemistry, Genetics and Molecular Biology. Their scholarly contributions primarily focus on Molecular Biology, Cell Biology, Genetics, Surgery, and Physiology.

The main topics of Shinji Takada's research encompass:

  • Wnt/β-catenin signaling in development and cancer
  • Developmental Biology and Gene Regulation
  • Congenital heart defects research
  • Proteoglycans and glycosaminoglycans research
  • Epigenetics and DNA Methylation
  • Fibroblast Growth Factor Research
  • Tissue Engineering and Regenerative Medicine

Shinji Takada has published numerous papers across various respected scientific journals. Recent papers include:

  • Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation, 2021, Science Advances
  • Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis, 2021, Nature Communications
  • Heparan Sulfate Proteoglycan Clustering in Wnt Signaling and Dispersal, 2020, Frontiers in Cell and Developmental Biology
  • Improvement of Phycocyanobilin Synthesis for Genetically Encoded Phytochrome-Based Optogenetics, 2020, ACS Chemical Biology
  • Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos, 2021, eLife

Frequent collaborators in their research include:

  • Yusuke Mii
  • Ritsuko Takada
  • Taijiro Yabe
  • Takuma Shinozuka
  • Tatsuya Takemoto

The venues where Shinji Takada most frequently publishes include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Cell and Developmental Biology
  • Nature Communications
  • Communications Biology
  • Developmental Dynamics

Their work spans diverse subfields with a notable emphasis on molecular biology, supporting ongoing investigations into cellular processes, gene regulation, and developmental mechanisms. Through studies involving signaling pathways such as Wnt/β-catenin, Takada contributes data relevant to congenital disorders, cancer biology, and regenerative medicine.

Best Publications

  • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

    Junhao Mao;Junhao Mao;Jiyong Wang;Bo Liu;Bo Liu;Weijun Pan

  • Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

    Jill A. McMahon;Shinji Takada;Lyle B. Zimmerman;Chen-Ming Fan

  • Wnt-3a regulates somite and tailbud formation in the mouse embryo.

    Shinji Takada;Kevin L. Stark;Martin J. Shea;Galya Vassileva

  • The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway

    Isao Oishi;Hiroaki Suzuki;Nobuyuki Onishi;Ritsuko Takada

  • Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion

    Ritsuko Takada;Yoshinori Satomi;Tomoko Kurata;Naoto Ueno;Naoto Ueno

  • Wnt signalling required for expansion of neural crest and CNS progenitors

    Makoto Ikeya;Scott M. K. Lee;Jane E. Johnson;Andrew P. McMahon

  • T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification

    Terry P. Yamaguchi;Shinji Takada;Yoshiaki Yoshikawa;Nongying Wu

  • FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis

    Norihiko Ohbayashi;Masaki Shibayama;Yoko Kurotaki;Mayumi Imanishi

  • A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.

    Ichiro Takada;Masatomo Mihara;Masatomo Mihara;Miyuki Suzawa;Fumiaki Ohtake

  • JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates

    Hiroaki Yamanaka;Tetsuo Moriguchi;Norihisa Masuyama;Morioh Kusakabe

  • Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability.

    Hideki Yamamoto;Shosei Kishida;Shosei Kishida;Michiko Kishida;Satoshi Ikeda

  • THE EXPRESSION OF THE MOUSE ZIC1, ZIC2, AND ZIC3 GENE SUGGESTS AN ESSENTIAL ROLE FOR ZIC GENES IN BODY PATTERN FORMATION

    Takeharu Nagai;Jun Aruga;Shinji Takada;Thomas Günther

  • Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

    Takahiro Fujino;Hiroshi Asaba;Man Jong Kang;Yukio Ikeda

  • Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a.

    Kazuhisa Takeda;Ken Ichi Yasumoto;Ritsuko Takada;Shinji Takada

  • Identification of a link between the tumour suppressor APC and the kinesin superfamily

    Takeshi Jimbo;Yoshihiro Kawasaki;Ryo Koyama;Rina Sato

  • EVIDENCE THAT ABSENCE OF WNT-3A SIGNALING PROMOTES NEURALIZATION INSTEAD OF PARAXIAL MESODERM DEVELOPMENT IN THE MOUSE

    Yoshiaki Yoshikawa;Toshihiko Fujimori;Andrew P. McMahon;Shinji Takada

  • Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord

    Yuko Muroyama;Motoyuki Fujihara;Makoto Ikeya;Hisato Kondoh

  • Regulation of mammalian tooth cusp patterning by ectodin.

    Yoshiaki Kassai;Pauliina Munne;Yuhei Hotta;Enni Penttilä

  • Cytoskeletal reorganization by soluble Wnt‐3a protein signalling

    Shibamoto;Keiichi Higano;Ritsuko Takada;Fumiaki Ito

  • Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development.

    Tamara L. Greco;Shinji Takada;Shinji Takada;Matthew M. Newhouse;Matthew M. Newhouse;Jill A. McMahon

Frequent Co-Authors

Hisato Kondoh
Hisato Kondoh Kyoto Sangyo University
Andrew P. McMahon
Andrew P. McMahon University of Southern California
Masuo Obinata
Masuo Obinata Tohoku University
Akira Kikuchi
Akira Kikuchi Osaka University
Yasuhiro Minami
Yasuhiro Minami Kobe University
Naoto Ueno
Naoto Ueno National Institute for Basic Biology
Yasuhisa Matsui
Yasuhisa Matsui Tohoku University
Shosei Yoshida
Shosei Yoshida The Graduate University for Advanced Studies, SOKENDAI
Takashi Tsuruo
Takashi Tsuruo Japanese Foundation For Cancer Research
Nobuyuki Itoh
Nobuyuki Itoh Kyoto University

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