Takashi Tsuruo

Overview

Best Publications

• Modulation of Akt kinase activity by binding to Hsp90

  Saori Sato;Naoya Fujita;Takashi Tsuruo

  1243
  Citations

• Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

  Thomas C. Hamilton;Margaret A. Winker;Karen G. Louie;Gerald Batist

  778
  Citations

• Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.

  Takashi Tsuruo;Mikihiko Naito;Akihiro Tomida;Naoya Fujita

  684
  Citations

• De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

  T Mashima;H Seimiya;T Tsuruo

  588
  Citations

• Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation

  Ikuo Saiki;Junya Yoneda;Ichiro Azuma;Hideji Fujii

  486
  Citations

• Domain Mapping Studies Reveal That the M Domain of hsp90 Serves as a Molecular Scaffold to Regulate Akt-Dependent Phosphorylation of Endothelial Nitric Oxide Synthase and NO Release

  Jason Fontana;David Fulton;Yan Chen;Todd A. Fairchild

  473
  Citations

• Brain pericytes contribute to the induction and up-regulation of blood–brain barrier functions through transforming growth factor-β production

  Shinya Dohgu;Fuyuko Takata;Atsushi Yamauchi;Shinsuke Nakagawa

  450
  Citations

• Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

  Mika Shimonaka;Mika Shimonaka;Koko Katagiri;Toshinori Nakayama;Naoya Fujita

  440
  Citations

• Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.

  Naoya Fujita;Saori Sato;Kazuhiro Katayama;Takashi Tsuruo;Takashi Tsuruo

  438
  Citations

• Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization

  Kumie Kage;Satomi Tsukahara;Tomomi Sugiyama;Sakiyo Asada

  399
  Citations

• The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.

  Takashi Kageyama;Masaru Nakamura;Akinori Matsuo;Yasuomi Yamasaki

  361
  Citations

• Actin cleavage by CPP-32/apopain during the development of apoptosis

  Tetsuo Mashima;Mikihiko Naito;Kohji Noguchi;Douglas K. Miller

  350
  Citations

• Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

  Daisuke Morishita;Ryohei Katayama;Kazuhisa Sekimizu;Takashi Tsuruo

  342
  Citations

• Molecular Identification of Aggrus/T1α as a Platelet Aggregation-inducing Factor Expressed in Colorectal Tumors

  Yukinari Kato;Naoya Fujita;Akiko Kunita;Shigeo Sato

  330
  Citations

• Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis.

  Yongke Zhang;Naoya Fujita;Takashi Tsuruo;Takashi Tsuruo

  329
  Citations

• G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.

  H Tahara;K Shin-Ya;H Seimiya;H Yamada

  324
  Citations

• Brain Capillary Endothelial Cells Express two forms of Erythropoietin Receptor mRNA

  Ryoichi Yamaji;Tadayuki Okada;Maki Moriya;Mikihiko Naito

  322
  Citations

• Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

  Yanyan Hao;Keiko Sekine;Atsushi Kawabata;Hitoshi Nakamura;Hitoshi Nakamura

  314
  Citations

• Breast cancer resistance protein exports sulfated estrogens but not free estrogens.

  Yasuo Imai;Sakiyo Asada;Satomi Tsukahara;Etsuko Ishikawa

  309
  Citations

• Alteration in copy numbers of genes as a mechanism for acquired drug resistance.

  Kohichiroh Yasui;Saori Mihara;Chen Zhao;Hiroyuki Okamoto

  283
  Citations