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Yoshihiro Mimaki

Yoshihiro Mimaki

D-Index & Metrics

Chemistry

D-Index
62
Citations
12959
World Ranking
8879
National Ranking
616

Overview

Yoshihiro Mimaki is affiliated with the University of Tokyo in Japan and has made contributions primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work focuses on Molecular Biology, Biomaterials, Plant Science, Pharmacology, and Biochemistry. The scientist's research emphasizes natural product bioactivities and synthesis, phytochemical studies and bioactivities, phytochemistry and bioactive compounds, as well as plant biochemistry and biosynthesis and the pharmacological effects of natural compounds.

The research output of Yoshihiro Mimaki includes publications in prominent venues such as:

  • Phytochemistry
  • Journal of Natural Medicines
  • Chemical and Pharmaceutical Bulletin
  • Phytochemistry Letters
  • Natural Product Research

Some recent notable papers authored or co-authored by Mimaki include:

  • Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity, 2020, Phytochemistry
  • Bufadienolides and ecdysteroids from the whole plants of Helleborus niger and their cytotoxicity, 2021, Journal of Natural Medicines
  • Bufadienolides from the whole plants of Helleborus foetidus and their cytotoxicity, 2020, Phytochemistry
  • Novel Steroidal Glycosides from the Whole Plants of Helleborus foetidus, 2020, Chemical and Pharmaceutical Bulletin
  • Cytotoxic triterpene and steroidal glycosides from the seeds of Digitalis purpurea and the synergistic cytotoxicity of steroidal glycosides and etoposide in SBC-3 cells, 2022, Bioorganic Chemistry

Frequent collaborators include:

  • Tomoki Iguchi
  • Akihito Yokosuka
  • Minpei Kuroda
  • Yukiko Matsuo
  • Naoki Takahashi

The thematic focus of Mimaki's research mainly revolves around natural products and their biological impacts, particularly investigating the structure, synthesis, and bioactivities of phytochemical compounds. The molecular and biochemical aspects of plant-derived substances and their pharmacological potentials remain central to the scientist's scholarly output.

Best Publications

  • Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages.

    Na Lin;Takashi Sato;Yuji Takayama;Yoshihiro Mimaki

  • Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer's Disease

    Hiroshi Onozuka;Akira Nakajima;Kentaro Matsuzaki;Ryong Woon Shin

  • Natural products reveal cancer cell dependence on oxysterol-binding proteins

    Anthony W G Burgett;Thomas B Poulsen;Kittikhun Wangkanont;D Ryan Anderson

  • Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs

    Yoshihiro Mimaki;Minpei Kuroda;Aiko Kameyama;Yutaka Sashida

  • Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.

    Takashi Sato;Leona Koike;Yoshiki Miyata;Michiko Hirata

  • Acylated cholestane glycosides from the bulbs of Ornithogalum saundersiae

    Satoshi Kubo;Yoshihiro Mimaki;Miki Terao;Yutaka Sashida

  • Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.

    Hiroyuki Nagase;Naoki Omae;Akiko Omori;Osamu Nakagawasai

  • Nobiletin restoring β-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats

    Kentaro Matsuzaki;Tohru Yamakuni;Michio Hashimoto;Abdul Md Haque

  • Cytotoxic Activities and Structure-Cytotoxic Relationships of Steroidal Saponins

    Yoshihiro Mimaki;Akihito Yokosuka;Minpei Kuroda;Yutaka Sashida

  • Mechanism of neurotrophic action of nobiletin in PC12D cells.

    Hiroyuki Nagase;Tohru Yamakuni;Kentaro Matsuzaki;Yuji Maruyama

  • Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.

    Akira Nakajima;Tohru Yamakuni;Mitsuya Haraguchi;Naoki Omae

  • Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).

    Akira Nakajima;Yuki Aoyama;Eun Joo Shin;Yunsung Nam

  • Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.

    Yui Yamamoto;Norifumi Shioda;Feng Han;Shigeki Moriguchi

  • Triterpene Saponins from the Roots of Clematis chinensis

    Yoshihiro Mimaki;Akihito Yokosuka;Mari Hamanaka;Chiseko Sakuma

  • A Licorice Ethanolic Extract with Peroxisome Proliferator-Activated Receptor-γ Ligand-Binding Activity Affects Diabetes in KK-Ay Mice, Abdominal Obesity in Diet-Induced Obese C57BL Mice and Hypertension in Spontaneously Hypertensive Rats

    Tatsumasa Mae;Hideyuki Kishida;Tozo Nishiyama;Misuzu Tsukagawa

  • Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced parkinson model mice

    Y. Yabuki;Y. Ohizumi;A. Yokosuka;Y. Mimaki

  • Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells.

    Yoshihiro Mimaki;Minpei Kuroda;Tomoki Asano;Yutaka Sashida

  • Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.

    Akira Nakajima;Yuki Aoyama;Thuy Ty Lan Nguyen;Eun Joo Shin

  • New diarylheptanoids and diarylheptanoid glucosides from the rhizomes of Tacca chantrieri and their cytotoxic activity.

    Akihito Yokosuka;Yoshihiro Mimaki;Hiroshi Sakagami;Yutaka Sashida

  • Phenolics with PPAR-γ ligand-Binding activity obtained from licorice (Glycyrrhiza uralensis Roots) and ameliorative effects of glycyrin on genetically diabetic KK-Ay mice

    Minpei Kuroda;Yoshihiro Mimaki;Yutaka Sashida;Tatsumasa Mae

Frequent Co-Authors

Yutaka Sashida
Yutaka Sashida University of Tokyo
Hiroshi Sakagami
Hiroshi Sakagami Meikai University
Hoyoku Nishino
Hoyoku Nishino Kyoto Prefectural University of Medicine
Yasushi Ohizumi
Yasushi Ohizumi Tohoku University
Takashi Tsuruo
Takashi Tsuruo Japanese Foundation For Cancer Research
Hideji Itokawa
Hideji Itokawa University of Tokyo
Hiroyuki Koshino
Hiroyuki Koshino Tokyo University of Agriculture
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Nobuyuki Harada
Nobuyuki Harada Tohoku University
Kohji Fukunaga
Kohji Fukunaga Tohoku University

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