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Christopher J. Roberts

Christopher J. Roberts

D-Index & Metrics

Chemistry

D-Index
51
Citations
9091
World Ranking
13970
National Ranking
3620

Overview

Christopher J. Roberts is affiliated with the University of Delaware in the United States. Their research focuses primarily on topics intersecting biochemistry, genetics, molecular biology, and medicine.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of their research cover areas such as:

  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging
  • Biomedical Engineering
  • Organic Chemistry
  • Materials Chemistry

The key scientific topics in their work involve:

  • Protein purification and stability
  • Monoclonal and Polyclonal Antibodies Research
  • Protein Structure and Dynamics
  • Microfluidic and Capillary Electrophoresis Applications
  • Enzyme Structure and Function
  • Microfluidic and Bio-sensing Technologies
  • Organometallic Complex Synthesis and Catalysis

Roberts has been published frequently in a range of scientific venues. These include:

  • Molecular Pharmaceutics (7 publications)
  • Journal of Pharmaceutical Sciences (4 publications)
  • The Journal of Physical Chemistry B (4 publications)
  • Biotechnology and Bioengineering (2 publications)
  • Biophysical Chemistry (2 publications)

Recent representative papers authored or coauthored by Roberts are:

  • "Temperature Dependence of Protein Solution Viscosity and Protein-Protein Interactions: Insights into the Origins of High-Viscosity Protein Solutions," 2020, Molecular Pharmaceutics
  • "Kinetics and Competing Mechanisms of Antibody Aggregation via Bulk- and Surface-Mediated Pathways," 2020, Journal of Pharmaceutical Sciences
  • "Antibodies Adsorbed to the Air-Water Interface Form Soft Glasses," 2023, Langmuir
  • "Toward a Suite of Coarse-Grained Models for Molecular Simulation of Monoclonal Antibodies and Therapeutic Proteins," 2021, The Journal of Physical Chemistry B
  • "Vaccine process technology-A decade of progress," 2024, Biotechnology and Bioengineering

Frequent collaborators include:

  • Qi Wei
  • Vladimir I. Razinkov
  • Hassan Shahfar
  • Eric M. Furst
  • James K. Forder

Best Publications

  • Therapeutic Protein Aggregation: Mechanisms, Design, and Control

    Christopher J. Roberts

  • Non-native protein aggregation kinetics.

    Christopher J. Roberts

  • Principles, approaches, and challenges for predicting protein aggregation rates and shelf life

    William F. Weiss;Teresa M. Young;Christopher J. Roberts

  • Protein aggregation and its impact on product quality.

    Christopher J Roberts

  • Stabilization of Pharmaceuticals to Oxidative Degradation

    Kenneth C. Waterman;Roger C. Adami;Karen M. Alsante;Jinyang Hong

  • A Lumry−Eyring Nucleated Polymerization Model of Protein Aggregation Kinetics: 1. Aggregation with Pre-Equilibrated Unfolding

    Jennifer M. Andrews;Christopher J. Roberts

  • Protein aggregation, particle formation, characterization & rheology

    Samiul Amin;Gregory V. Barnett;Jai A. Pathak;Christopher J. Roberts

  • Comparative Effects of pH and Ionic Strength on Protein–Protein Interactions, Unfolding, and Aggregation for IgG1 Antibodies

    Erinc Sahin;Adeola O. Grillo;Melissa D. Perkins;Christopher J. Roberts

  • Protein aggregation - Mechanisms, detection, and control.

    Wei Wang;Christopher J. Roberts

  • Kinetics of Irreversible Protein Aggregation: Analysis of Extended Lumry−Eyring Models and Implications for Predicting Protein Shelf Life

    Christopher J. Roberts

  • Lumry-Eyring nucleated-polymerization model of protein aggregation kinetics. 2. Competing growth via condensation and chain polymerization.

    Yi Li;Christopher J. Roberts

  • Non-Arrhenius protein aggregation.

    Wei Wang;Christopher J. Roberts

  • Liquid-Liquid Immiscibility in Pure Fluids: Polyamorphism in Simulations of a Network-Forming Fluid.

    C. J. Roberts;A. Z. Panagiotopoulos;Pablo G. Debenedetti

  • Polyamorphism and density anomalies in network‐forming fluids: Zeroth‐ and first‐order approximations

    C. J. Roberts;Pablo G. Debenedetti

  • Aggregation of therapeutic proteins

    Wei Wang;Christopher J. Roberts

  • Structure and dynamics in concentrated, amorphous carbohydrate--water systems by molecular dynamics simulation

    C. J. Roberts;Pablo G. Debenedetti

  • Predicting solution aggregation rates for therapeutic proteins: approaches and challenges.

    Christopher J. Roberts;Tapan K. Das;Erinc Sahin

  • Nonnative aggregation of an IgG1 antibody in acidic conditions: Part 1. Unfolding, colloidal interactions, and formation of high‐molecular‐weight aggregates

    Rebecca K. Brummitt;Rebecca K. Brummitt;Douglas P. Nesta;Liuquan Chang;Liuquan Chang;Susan F. Chase

  • Characterization of high‐molecular‐weight nonnative aggregates and aggregation kinetics by size exclusion chromatography with inline multi‐angle laser light scattering

    Yi Li;William F. Weiss;Christopher J. Roberts

  • Nonnative aggregation of an IgG1 antibody in acidic conditions, part 2: Nucleation and growth kinetics with competing growth mechanisms

    Rebecca K. Brummitt;Rebecca K. Brummitt;Douglas P. Nesta;Liuquan Chang;Liuquan Chang;Andrew M. Kroetsch

Frequent Co-Authors

Eric M. Furst
Eric M. Furst University of Delaware
Kristi L. Kiick
Kristi L. Kiick University of Delaware
Thomas M. Laue
Thomas M. Laue University of New Hampshire
Pablo G. Debenedetti
Pablo G. Debenedetti Princeton University
Xinqiao Jia
Xinqiao Jia University of Delaware
Paul D. Butler
Paul D. Butler National Institute of Standards and Technology
Frank H. Stillinger
Frank H. Stillinger Princeton University
Abraham M. Lenhoff
Abraham M. Lenhoff University of Delaware
Bernd Nidetzky
Bernd Nidetzky Graz University of Technology
Feng Jiao
Feng Jiao Washington University in St. Louis

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