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Bernhardt L. Trout

Bernhardt L. Trout

D-Index & Metrics

Chemistry

D-Index
77
Citations
18102
World Ranking
4111
National Ranking
1301

Overview

Bernhardt L. Trout is affiliated with MIT in the United States and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology as well as Engineering. Their research encompasses a range of topics primarily focused on protein science and antibody behavior.

The main subjects of Bernhardt L. Trout's research include:

  • Protein purification and stability
  • Monoclonal and Polyclonal Antibodies Research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Glycosylation and Glycoproteins Research
  • Microfluidic and Capillary Electrophoresis Applications
  • Protein Structure and Dynamics
  • Methane Hydrates and Related Phenomena

Their work often intersects with subfields such as Molecular Biology, Radiology, Nuclear Medicine and Imaging, and Biomedical Engineering, reflecting a multidisciplinary approach within both biological and engineering contexts.

Bernhardt L. Trout has published research extensively in several scientific venues. The most frequent publication platforms include:

  • mAbs
  • Journal of Pharmaceutical Sciences
  • Molecular Pharmaceutics
  • The Journal of Physical Chemistry B
  • SSRN Electronic Journal

Recent publications by Bernhardt L. Trout highlight contributions to understanding antibody formulation and aggregation using computational and machine learning techniques. Notable papers include:

  • Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics, 2022, mAbs
  • Machine Learning Applied to Determine the Molecular Descriptors Responsible for the Viscosity Behavior of Concentrated Therapeutic Antibodies, 2021, Molecular Pharmaceutics
  • Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters, 2021, mAbs
  • Machine Learning Feature Selection for Predicting High Concentration Therapeutic Antibody Aggregation, 2020, Journal of Pharmaceutical Sciences
  • Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity, 2020, mAbs

Their frequent collaborators include:

  • Richard D. Braatz
  • Pin-Kuang Lai
  • Theresa K. Cloutier
  • Allan S. Myerson
  • Neil Mody

This collaboration network reflects interdisciplinary work bridging computational methods, pharmaceutical sciences, and molecular biology. Bernhardt L. Trout's research contributions focus strongly on the challenges of antibody aggregation, viscosity behavior, and formulation development for therapeutic applications with an emphasis on machine learning and computational modeling methodologies.

Best Publications

  • End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

    Salvatore Mascia;Patrick L. Heider;Haitao Zhang;Richard Lakerveld

  • Design of therapeutic proteins with enhanced stability

    Naresh Chennamsetty;Vladimir Voynov;Veysel Kayser;Bernhard Helk

  • Mechanisms of protein stabilization and prevention of protein aggregation by glycerol.

    Vincent Vagenende;Miranda G. S. Yap;Bernhardt L. Trout;Bernhardt L. Trout

  • Economic Analysis of Integrated Continuous and Batch Pharmaceutical Manufacturing: A Case Study

    Spencer D. Schaber;Dimitrios I. Gerogiorgis;Rohit Ramachandran;James M. B. Evans

  • Obtaining reaction coordinates by likelihood maximization.

    Baron Peters;Bernhardt L. Trout

  • A new approach for studying nucleation phenomena using molecular simulations: Application to CO2 hydrate clathrates

    Ravi Radhakrishnan;Bernhardt L. Trout

  • Role of arginine in the stabilization of proteins against aggregation.

    Brian M Baynes;Daniel I C Wang;Bernhardt L Trout

  • Properties of inhibitors of methane hydrate formation via molecular dynamics simulations.

    Brian J. Anderson;Jefferson W. Tester;Gian Paolo Borghi;Bernhardt L. Trout

  • Modified ligand-exchange for efficient solubilization of CdSe/ZnS quantum dots in water: a procedure guided by computational studies.

    Boon-Kin Pong;Bernhardt L. Trout;Jim-Yang Lee

  • Interaction of Arginine with Proteins and the Mechanism by Which It Inhibits Aggregation

    Diwakar Shukla;Bernhardt L. Trout

  • A super-linear minimization scheme for the nudged elastic band method

    Jhih-Wei Chu;Bernhardt L. Trout;Bernard R. Brooks

  • Surface design for controlled crystallization: the role of surface chemistry and nanoscale pores in heterogeneous nucleation.

    Ying Diao;Allan S. Myerson;T. Alan Hatton;Bernhardt L. Trout

  • Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme.

    Justin J. Maresh;Lesley Ann Giddings;Anne Friedrich;Elke A. Loris

  • Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

    Timothy M. Lauer;Neeraj J. Agrawal;Naresh Chennamsetty;Kamal Egodage

  • Nucleation from Solution

    Allan S. Myerson;Bernhardt L. Trout

  • Extensions to the likelihood maximization approach for finding reaction coordinates

    Baron Peters;Gregg T. Beckham;Bernhardt L. Trout

  • Proteins in Mixed Solvents: A Molecular-level Perspective

    Brian M. Baynes;Bernhardt L. Trout

  • Density Functional Theory Study of Ligand Binding on CdSe (0001), (0001̄), and (112̄0) Single Crystal Relaxed and Reconstructed Surfaces: Implications for Nanocrystalline Growth

    Jane Y Rempel;Bernhardt L Trout;Moungi G Bawendi;Klavs F Jensen

  • Prediction of aggregation prone regions of therapeutic proteins.

    Naresh Chennamsetty;Vladimir Voynov;Veysel Kayser;Bernhard Helk

  • The role of nanopore shape in surface-induced crystallization

    Ying Diao;Takuya Harada;Takuya Harada;Allan S. Myerson;T. Alan Hatton

  • Analysis of the Thermochemistry of NOx Decomposition over CuZSM-5 Based on Quantum Chemical and Statistical Mechanical Calculations

    Bernhardt L. Trout;and Arup K. Chakraborty;Alexis T. Bell

Frequent Co-Authors

Baron Peters
Baron Peters University of Illinois at Urbana-Champaign
Jefferson W. Tester
Jefferson W. Tester Cornell University
Daniel I. C. Wang
Daniel I. C. Wang Chinese Academy of Tropical Agricultural Sciences
Mario J. Molina
Mario J. Molina University of California, San Diego
Ying Diao
Ying Diao University of Illinois at Urbana-Champaign
Franz M. Geiger
Franz M. Geiger Northwestern University

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