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C. Russell Middaugh

C. Russell Middaugh

D-Index & Metrics

Chemistry

D-Index
74
Citations
18755
World Ranking
4722
National Ranking
1488

Overview

C. Russell Middaugh is affiliated with the University of Kansas in the United States and has contributed extensively to research in the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Their work spans various subfields including Molecular Biology, Immunology, Epidemiology, Infectious Diseases, and Biomedical Engineering.

The scientist's research addresses core topics such as protein purification and stability, viral infectious diseases and gene expression in insects, protein structure and dynamics, RNA interference and gene delivery, immune response and inflammation, immunotherapy and immune responses, as well as monoclonal and polyclonal antibodies research.

Notable recent papers authored or co-authored by C. Russell Middaugh include:

  • pH-Dependent Phase Behavior and Stability of Cationic Lipid-mRNA Nanoparticles, 2021, Journal of Pharmaceutical Sciences
  • Optimization of RG1-VLP Vaccine Performance in Mice with Novel TLR4 Agonists, 2020, Vaccine
  • Prediction Machines: Applied Machine Learning for Therapeutic Protein Design and Development, 2020, Journal of Pharmaceutical Sciences
  • Short-term and Longer-term Protective Immune Responses Generated by Subunit Vaccination with Smallpox A33, B5, L1 or A27 Proteins Adjuvanted with Aluminum Hydroxide and CpG in Mice Challenged with Vaccinia Virus, 2020, Vaccine
  • Physicochemical Characterization of Biological and Synthetic Forms of Two Lipid A-based TLR4 Agonists, 2023, Heliyon

C. Russell Middaugh has frequently published in a few key venues including the Journal of Pharmaceutical Sciences, Vaccine, Biomolecules, Heliyon, and Frontiers in Immunology.

Throughout their career, Middaugh has collaborated with multiple researchers, often working alongside:

  • Nicholas R. Larson
  • Yangjie Wei
  • Gang Hu
  • Akshay Jain
  • Krzysztof Kuczera

Best Publications

  • Overlooking subvisible particles in therapeutic protein products: Gaps that may compromise product quality

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

  • Statistical determination of the average values of the extinction coefficients of tryptophan and tyrosine in native proteins

    H Mach;C R Middaugh;R V Lewis

  • Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

    Tim J. Kamerzell;Reza Esfandiary;Sangeeta B. Joshi;C. Russell Middaugh

  • Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies.

    Ozan S. Kumru;Sangeeta B. Joshi;Dawn E. Smith;C. Russell Middaugh

  • Silicone oil induced aggregation of proteins

    LaToya S. Jones;Allyn Kaufmann;C.Russell Middaugh

  • Biophysical characterization of PEI/DNA complexes.

    Sirirat Choosakoonkriang;Brian A. Lobo;Gary S. Koe;Janet G. Koe

  • Structure/Function Relationships of Polyamidoamine/DNA Dendrimers as Gene Delivery Vehicles

    Chad S. Braun;Joseph A. Vetro;Donald A. Tomalia;Gary S. Koe

  • Conformational Stability and Disassembly of Norwalk Virus-like Particles EFFECT OF pH AND TEMPERATURE

    Salvador F. Ausar;Thomas R. Foubert;Mary H. Hudson;Thomas S. Vedvick

  • Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release

    Wim Jiskoot;Theodore W. Randolph;David B. Volkin;C. Russell Middaugh

  • Nature of the interaction of heparin with acidic fibroblast growth factor

    Henryk Mach;David B. Volkin;Carl J. Burke;C. Russell Middaugh

  • Thermal Stability of Vaccines

    Duane T. Brandau;Latoya S. Jones;Christopher M. Wiethoff;Jason Rexroad

  • Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

  • Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens.

    LaToya S. Jones;Laura J. Peek;Jonathan Power;Aaron Markham

  • Analysis of plasmid DNA from a pharmaceutical perspective

    C. Russell Middaugh;Robert K. Evans;Donna L. Montgomery;Danilo R. Casimiro

  • Insulin containing polyethylenimine-dextran sulfate nanoparticles

    Waree Tiyaboonchai;James Woiszwillo;Robert C Sims;C.Russell Middaugh

  • The Structure of DNA within Cationic Lipid/DNA Complexes

    Chad S. Braun;Gouri S. Jas;Sirirat Choosakoonkriang;Gary S. Koe

  • Highly concentrated monoclonal antibody solutions: direct analysis of physical structure and thermal stability.

    Unknown

  • Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase.

    Unknown

  • High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability

    Rajoshi Chaudhuri;Rajoshi Chaudhuri;Yuan Cheng;C. Russell Middaugh;David B. Volkin

  • Investigation of protein/carbohydrate interactions in the dried state. 2. Diffuse reflectance FTIR studies

    Pierre O Souillac;C.Russell Middaugh;J.Howard Rytting

  • Spectroscopic evaluation of the stabilization of humanized monoclonal antibodies in amino acid formulations.

    Fei Tian;C. Russell Middaugh;Tom Offerdahl;Eric Munson

  • Derivative Absorbance Spectroscopy and Protein Phase Diagrams as Tools for Comprehensive Protein Characterization: A bGCSF Case Study

    Lisa A. Kueltzo;Baran Ersoy;John P. Ralston;C.Russell. Middaugh

  • The potential role of proteoglycans in cationic lipid-mediated gene delivery. Studies of the interaction of cationic lipid-DNA complexes with model glycosaminoglycans.

    Christopher M. Wiethoff;Janet G. Smith;Gary S. Koe;C. Russell Middaugh

Frequent Co-Authors

David B. Volkin
David B. Volkin University of Kansas
Nicholas J. Mantis
Nicholas J. Mantis New York State Department of Health
Christian Schöneich
Christian Schöneich University of Kansas
Ronald T. Borchardt
Ronald T. Borchardt University of Kansas
Randolph V. Lewis
Randolph V. Lewis Utah State University
Gerhard Winter
Gerhard Winter Ludwig-Maximilians-Universität München
Richard L. Schowen
Richard L. Schowen University of Kansas
Michael Blaber
Michael Blaber Florida State University
John F. Carpenter
John F. Carpenter University of Colorado Anschutz Medical Campus
Theodore W. Randolph
Theodore W. Randolph University of Colorado Boulder

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