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Chemistry

D-Index
59
Citations
10436
World Ranking
10325
National Ranking
2858

Research.com Recognitions

  • 2020 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Linda O. Narhi is affiliated with Amgen in the United States and focuses their research in the fields of biochemistry, genetics, molecular biology, immunology, and microbiology. Their work encompasses molecular biology and immunology as primary subfields of study.

Their research topics include:

  • Protein purification and stability
  • Biosimilars and Bioanalytical Methods
  • Viral Infectious Diseases and Gene Expression in Insects
  • Monoclonal and Polyclonal Antibodies Research
  • Safe Handling of Antineoplastic Drugs
  • Environmental Impact and Sustainability
  • Extraction and Separation Processes

They have contributed to several recent publications:

  • "Stress Factors in Protein Drug Product Manufacturing and Their Impact on Product Quality," 2021, Journal of Pharmaceutical Sciences
  • "Stress Factors in Primary Packaging, Transportation and Handling of Protein Drug Products and Their Impact on Product Quality," 2022, Journal of Pharmaceutical Sciences
  • "Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies," 2023, mAbs
  • "A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic," 2024, Pharmaceutical Research
  • "Evaluating Clinical Safety and Analytical Impact of Subvisible Silicone Oil Particles in Biopharmaceutical Products," 2024, Journal of Pharmaceutical Sciences

Frequent co-authors collaborating with them include:

  • Tapan K. Das
  • Alavattam Sreedhara
  • Danny K. Chou
  • Twinkle R. Christian
  • Wim Jiskoot

The preferred venues for publishing their work are:

  • Journal of Pharmaceutical Sciences
  • mAbs
  • Pharmaceutical Research
  • SSRN Electronic Journal

Linda O. Narhi was recognized as a Fellow of the Indian National Academy of Engineering (INAE) in 2020. Their research contributions provide insight into the production, handling, and safety of protein-based biotherapeutic products, with an emphasis on quality control and immunogenic response mechanisms.

Best Publications

  • Both Familial Parkinson’s Disease Mutations Accelerate α-Synuclein Aggregation

    Linda Narhi;Stephen J. Wood;Shirley Steavenson;Yijia Jiang

  • Immunogenicity of Therapeutic Protein Aggregates

    Ehab M. Moussa;Jainik P. Panchal;Balakrishnan S. Moorthy;Janice S. Blum

  • Classification and Characterization of Therapeutic Antibody Aggregates

    Marisa K. Joubert;Quanzhou Luo;Yasser Nashed-Samuel;Jette Wypych

  • Highly Aggregated Antibody Therapeutics Can Enhance the in Vitro Innate and Late-stage T-cell Immune Responses

    Marisa K. Joubert;Martha Hokom;Catherine Eakin;Lei Zhou

  • The effect of carbohydrate on the structure and stability of erythropoietin.

    L O Narhi;T Arakawa;K H Aoki;R Elmore

  • Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction.

    John S. Philo;Kenneth H. Aoki;Tsutomu Arakawa;Linda Owers Narhi

  • Classification of protein aggregates

    Linda O. Narhi;Jeremy Schmit;Karoline Bechtold-Peters;Deepak Sharma

  • Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs

    Anja Leona Biere;Stephen J. Wood;Jette Wypych;Shirley Steavenson

  • Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.

    Sampathkumar Krishnan;Eva Y Chi;Stephen J Wood;Brent S Kendrick

  • Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions

    Quanzhou Luo;Marisa K. Joubert;Riki Stevenson;Randal R. Ketchem

  • High throughput thermostability screening of monoclonal antibody formulations

    Feng He;Sabine Hogan;Ramil F. Latypov;Linda O. Narhi

  • A Critical Review of Analytical Methods for Subvisible and Visible Particles

    Linda O. Narhi;Yijia Jiang;Shawn Cao;Kalman Benedek

  • Thermal stability comparison of purified empty and peptide-filled forms of a class I MHC molecule.

    Margaret L. Fahnestock;Ilana Tamir;Linda Narhi;Pamela J. Bjorkman

  • CommentariesClassification of Protein Aggregates1

    Linda O. Narhi;Jeremy Schmit;Karoline Bechtold-Peters;Deepak Sharma

  • Effect of ions on agitation- and temperature-induced aggregation reactions of antibodies.

    R. Matthew Fesinmeyer;Sabine Hogan;Atul Saluja;Stephen R. Brych

  • Qualification of FTIR spectroscopic method for protein secondary structural analysis

    Yijia Jiang;Cynthia Li;Xichdao Nguyen;Salman Muzammil

  • Applications of circular dichroism (CD) for structural analysis of proteins: qualification of near‐ and far‐UV CD for protein higher order structural analysis

    Cynthia H. Li;Xichdao Nguyen;Linda Narhi;Letha Chemmalil

  • Glycosylated and unglycosylated recombinant-derived human stem cell factors are dimeric and have extensive regular secondary structure.

    T. Arakawa;D.A. Yphantis;J.W. Lary;L.O. Narhi

  • High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions.

    Feng He;Gerald W. Becker;Jennifer R. Litowski;Linda O. Narhi

  • Strategies To Suppress Aggregation of Recombinant Keratinocyte Growth Factor during Liquid Formulation Development

    Bao‐Lu Chen;Tsutomu Arakawa;Eric Hsu;Linda O. Narhi

  • Oxidative refolding of insulin-like growth factor 1 yields two products of similar thermodynamic stability : a bifurcating protein-folding pathway

    J A Miller;L O Narhi;Q X Hua;R Rosenfeld

Frequent Co-Authors

Tsutomu Arakawa
Tsutomu Arakawa Amgen (United States)
Hsieng Sen Lu
Hsieng Sen Lu Amgen (United States)
Keith Langley
Keith Langley University College London
Martin Citron
Martin Citron Amgen (United States)
John F. Carpenter
John F. Carpenter University of Colorado Anschutz Medical Campus
Stephen J. Wood
Stephen J. Wood University of Melbourne
Ivan Rayment
Ivan Rayment University of Wisconsin–Madison
Douglas C. Rees
Douglas C. Rees California Institute of Technology
Wim Jiskoot
Wim Jiskoot Leiden University
Pamela J. Bjorkman
Pamela J. Bjorkman California Institute of Technology

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