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Chemistry

D-Index
63
Citations
13212
World Ranking
8481
National Ranking
615

Overview

Gerhard Winter is affiliated with Ludwig-Maximilians-Universität München in Germany. Their research spans several interconnected fields including Biochemistry, Genetics and Molecular Biology, Materials Science, and Medicine. Within these disciplines, the scientist has contributed notably to the subfields of Molecular Biology, Biomaterials, Biomedical Engineering, Surgery, and Pharmaceutical Science.

The core of Winter's research work focuses on advanced drug delivery systems, primarily utilizing nanoparticle-based approaches. This includes significant study of thermosensitive liposomes, their interactions with cells, and mechanisms for targeted drug release. The main research topics encompass:

  • Nanoparticle-Based Drug Delivery
  • RNA Interference and Gene Delivery
  • Nanoplatforms for Cancer Theranostics
  • Lipid Membrane Structure and Behavior
  • Bladder and Urothelial Cancer Treatments
  • Advanced Drug Delivery Systems
  • Ultrasound and Hyperthermia Applications

Winter's publication record highlights papers published primarily in journals such as the Journal of Controlled Release, International Journal of Nanomedicine, and Advanced NanoBiomed Research. Notable recent papers include:

  • "Effects of Surface Charge, PEGylation and Functionalization with Dipalmitoylphosphatidyldiglycerol on Liposome-Cell Interactions and Local Drug Delivery to Solid Tumors via Thermosensitive Liposomes" (2021, International Journal of Nanomedicine)
  • "Hyperthermia-induced doxorubicin delivery from thermosensitive liposomes via MR-HIFU in a pig model" (2022, Journal of Controlled Release)
  • "DPPG2-Based Thermosensitive Liposomes with Encapsulated Doxorubicin Combined with Hyperthermia Lead to Higher Doxorubicin Concentrations in the Bladder Compared to Conventional Application in Pigs: A Rationale for the Treatment of Muscle-Invasive Bladder Cancer" (2021, International Journal of Nanomedicine)
  • "Mechanistic investigation of thermosensitive liposome immunogenicity and understanding the drivers for circulation half-life: A polyethylene glycol versus 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol study" (2021, Journal of Controlled Release)
  • "A Heat-Activated Drug-Delivery Platform Based on Phosphatidyl-(oligo)-glycerol Nanocarrier for Effective Cancer Treatment" (2021, Advanced NanoBiomed Research)

Frequent co-authors collaborating with Winter include:

  • Lars H. Lindner
  • Wouter J.M. Lokerse
  • Barbara Wedmann
  • Holger Grüll
  • Iris Brummelhuis

The prominent publication venues reflecting Winter's research contributions are:

  • Journal of Controlled Release
  • International Journal of Nanomedicine
  • Advanced NanoBiomed Research
  • International Journal of Hyperthermia
  • Biochimica et Biophysica Acta (BBA) - Biomembranes

Best Publications

  • Overlooking subvisible particles in therapeutic protein products: Gaps that may compromise product quality

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

  • Thermosensitive liposomal drug delivery systems: state of the art review.

    Barbara Kneidl;Michael Peller;Gerhard Winter;Lars H Lindner

  • Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release

    Wim Jiskoot;Theodore W. Randolph;David B. Volkin;C. Russell Middaugh

  • Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

  • Particles in Therapeutic Protein Formulations, Part 1: Overview of Analytical Methods

    Sarah Zölls;Ruedeeporn Tantipolphan;Michael Wiggenhorn;Gerhard Winter

  • Quantitation of Aggregate Levels in a Recombinant Humanized Monoclonal Antibody Formulation by Size-Exclusion Chromatography, Asymmetrical Flow Field Flow Fractionation, and Sedimentation Velocity

    John P. Gabrielson;Mark L. Brader;Allen H. Pekar;Kathrin B. Mathis

  • The use of asymmetrical flow field-flow fractionation in pharmaceutics and biopharmaceutics

    Wolfgang Fraunhofer;Gerhard Winter

  • Microencapsulation of rh-erythropoietin, using biodegradable poly(d,l-lactide-co-glycolide): protein stability and the effects of stabilizing excipients

    Michael Morlock;Hans Koll;Gerhard Winter;Thomas Kissel

  • Protein stabilization by cyclodextrins in the liquid and dried state.

    Tim Serno;Raimund Geidobler;Gerhard Winter

  • Crystalline anti-htnfalpha antibodies

    David W. Borhani;Wolfgang Fraunhofer;Hans-Juergen Krause;Anette Koenigsdorfer

  • Controlled ice nucleation in the field of freeze-drying: fundamentals and technology review.

    R. Geidobler;G. Winter

  • Lyophilized Drug Product Cake Appearance: What Is Acceptable?

    Sajal Manubhai Patel;Steven L. Nail;Michael J. Pikal;Raimund Geidobler

  • Silicon Nitride—From Powder Synthesis to Ceramic Materials

    Horst Lange;Gerhard Wötting;Gerhard Winter

  • Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

    Angela Schoch;Hubert Kettenberger;Olaf Mundigl;Gerhard Winter

  • Recent advances and further challenges in lyophilization.

    Julia Christina Kasper;Gerhard Winter;Wolfgang Friess

  • Recombinant spider silk particles as drug delivery vehicles

    Andreas Lammel;Martin Schwab;Markus Hofer;Gerhard Winter

  • Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics

    Beate Bittner;Michael Morlock;Hans Koll;Gerhard Winter

  • Micro–Flow Imaging and Resonant Mass Measurement (Archimedes) – Complementary Methods to Quantitatively Differentiate Protein Particles and Silicone Oil Droplets

    Daniel Weinbuch;Sarah Zölls;Michael Wiggenhorn;Wolfgang Friess

  • Matrix-loaded biodegradable gelatin nanoparticles as new approach to improve drug loading and delivery.

    Kenneth Ofokansi;Gerhard Winter;Gert Fricker;Conrad Coester;Conrad Coester

  • Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in-vitro release properties.

    Michael Morlock;Thomas Kissel;You Xin Li;Hans Koll

  • Compositions and methods for crystallizing antibodies

    Wolfgang Fraunhofer;David W. Borhani;Gerhard Winter;Stefan Gottschalk

  • Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity

    Carole Bourquin;David Anz;Klaus Zwiorek;Anna-Lisa Lanz

Frequent Co-Authors

John F. Carpenter
John F. Carpenter University of Colorado Anschutz Medical Campus
Theodore W. Randolph
Theodore W. Randolph University of Colorado Boulder
Wim Jiskoot
Wim Jiskoot Leiden University
C. Russell Middaugh
C. Russell Middaugh University of Kansas
Thomas Scheibel
Thomas Scheibel University of Bayreuth
Ernst Wagner
Ernst Wagner Ludwig-Maximilians-Universität München
Günther H.J. Peters
Günther H.J. Peters Technical University of Denmark
Christine M. Papadakis
Christine M. Papadakis Technical University of Munich
Thomas Kissel
Thomas Kissel Philipp University of Marburg
David B. Volkin
David B. Volkin University of Kansas

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