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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
101
Citations
35322
World Ranking
1453
National Ranking
25

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Wim Jiskoot is affiliated with Leiden University in the Netherlands. Their research spans several fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology, with a substantial focus on pharmaceutical sciences and molecular biology.

The main subfields of study include Molecular Biology, Immunology, Radiology, Nuclear Medicine and Imaging, Biomedical Engineering, and Pharmaceutical Science.

Jiskoot's work covers a range of topics, notably:

  • Protein purification and stability
  • Monoclonal and Polyclonal Antibodies Research
  • RNA Interference and Gene Delivery
  • Immunotherapy and Immune Responses
  • Biosimilars and Bioanalytical Methods
  • Viral Infectious Diseases and Gene Expression in Insects
  • Microfluidic and Bio-sensing Technologies

The scientist has published frequently in the following venues:

  • Journal of Pharmaceutical Sciences
  • International Journal of Pharmaceutics
  • European Journal of Pharmaceutics and Biopharmaceutics
  • Cytotherapy
  • Frontiers in Allergy

Among recent papers associated with Jiskoot are:

  • "Ongoing Challenges to Develop High Concentration Monoclonal Antibody-based Formulations for Subcutaneous Administration: Quo Vadis?" (2021), Journal of Pharmaceutical Sciences
  • "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability" (2021), International Journal of Pharmaceutics
  • "Addressing the Cold Reality of mRNA Vaccine Stability" (2020), Journal of Pharmaceutical Sciences
  • "Oxidation and Deamidation of Monoclonal Antibody Products: Potential Impact on Stability, Biological Activity, and Efficacy" (2021), Journal of Pharmaceutical Sciences
  • "Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for Pharmacogenetics" (2020), Genes

Frequent coauthors contributing alongside Jiskoot include:

  • Andrea Hawe
  • Bram Slütter
  • Alexander Kros
  • Joke A. Bouwstra
  • Tim Menzen

Best Publications

  • Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates

    Vasco Filipe;Vasco Filipe;Andrea Hawe;Wim Jiskoot

  • mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability.

    Linde Schoenmaker;Dominik Witzigmann;Jayesh A. Kulkarni;Rein Verbeke

  • Extrinsic fluorescent dyes as tools for protein characterization.

    Andrea Hawe;Marc Sutter;Marc Sutter;Wim Jiskoot

  • Protein instability in poly(lactic-co-glycolic acid) microparticles.

    Marco van de Weert;Wim E. Hennink;Wim Jiskoot

  • Structure-immunogenicity relationships of therapeutic proteins.

    Suzanne Hermeling;Daan J. A. Crommelin;Huub Schellekens;Wim Jiskoot

  • Identification of Formaldehyde-induced Modifications in Proteins REACTIONS WITH MODEL PEPTIDES

    Bernard Metz;Gideon F.A. Kersten;Peter Hoogerhout;Humphrey F. Brugghe

  • Chitosan-based delivery systems for protein therapeutics and antigens

    Maryam Amidi;Enrico Mastrobattista;Wim Jiskoot;Wim E. Hennink

  • Overlooking subvisible particles in therapeutic protein products: Gaps that may compromise product quality

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

  • Microneedle technologies for (trans)dermal drug and vaccine delivery.

    Koen van der Maaden;Wim Jiskoot;Joke Bouwstra

  • Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system.

    Maryam Amidi;Stefan G. Romeijn;Gerrit Borchard;Hans E. Junginger

  • ESAT-6 from Mycobacterium tuberculosis Dissociates from Its Putative Chaperone CFP-10 under Acidic Conditions and Exhibits Membrane-Lysing Activity

    Marien I. de Jonge;Gérard Pehau-Arnaudet;Marjan M. Fretz;Felix Romain

  • Addressing the Cold Reality of mRNA Vaccine Stability.

    Daan J.A. Crommelin;Thomas J. Anchordoquy;David B. Volkin;Wim Jiskoot

  • Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

    John den Engelsman;Patrick Garidel;Ronald Smulders;Hans Koll

  • N-Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: Biological properties and immunogenicity in a mouse model

    Maryam Amidi;Stefan G. Romeijn;J. Coos Verhoef;Hans E. Junginger

  • CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses.

    Rodney A. Rosalia;Luis J. Cruz;Suzanne van Duikeren;Angelino T. Tromp

  • Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release

    Wim Jiskoot;Theodore W. Randolph;David B. Volkin;C. Russell Middaugh

  • Shifting paradigms: biopharmaceuticals versus low molecular weight drugs

    Daan J.A. Crommelin;Gert Storm;Ruud Verrijk;Leo de Leede

  • Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress.

    Andrea Hawe;Julia Christina Kasper;Wolfgang Friess;Wim Jiskoot

  • Forced degradation of therapeutic proteins.

    Andrea Hawe;Michael Wiggenhorn;Marco van de Weert;Joerg H.O. Garbe

  • Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products

    John F. Carpenter;Theodore W. Randolph;Wim Jiskoot;Daan J.A. Crommelin

Frequent Co-Authors

Daan J.A. Crommelin
Daan J.A. Crommelin Utrecht University
Gideon F.A. Kersten
Gideon F.A. Kersten Leiden University
Joke A. Bouwstra
Joke A. Bouwstra Leiden University
Wim E. Hennink
Wim E. Hennink Utrecht University
Huub Schellekens
Huub Schellekens Utrecht University
Alexander Kros
Alexander Kros Leiden University
Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Geert-Jan Witkamp
Geert-Jan Witkamp King Abdullah University of Science and Technology
Johan Kuiper
Johan Kuiper Leiden University
James N. Herron
James N. Herron University of Utah

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