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Biology and Biochemistry

D-Index
74
Citations
17728
World Ranking
5660
National Ranking
140

Overview

Johan Kuiper is a researcher affiliated with Leiden University in the Netherlands. Their work primarily spans the fields of immunology and microbiology, with substantial contributions to medicine. The research subfields that Kuiper engages with most frequently include immunology, molecular biology, oncology, epidemiology, and genetics.

Kuiper's research covers various topics, with a significant focus on atherosclerosis and cardiovascular diseases. Other notable topics include single-cell and spatial transcriptomics, adipokines, inflammation, and metabolic diseases, immune cells in cancer, T-cell and B-cell immunology, mast cells and histamine, and galectins and cancer biology.

The scientist has published extensively, with recent papers reflecting a focus on cellular and molecular mechanisms in cardiovascular and immune contexts. Important recent publications include:

  • Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics, 2020, Circulation Research
  • The Dynamics of B Cell Aging in Health and Disease, 2021, Frontiers in Immunology
  • Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells, 2023, Nature Cardiovascular Research
  • Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis, 2021, European Heart Journal Open
  • Effects of fatty acids on T cell function: role in atherosclerosis, 2021, Nature Reviews Cardiology

Kuiper has repeatedly collaborated with several researchers, reflecting ongoing partnerships in their field. Frequent co-authors include Ilze Bot, Amanda C. Foks, Marie A.C. Depuydt, Menno P.J. de Winther, and Bram Slütter.

The scientist's scholarly output appears regularly in certain publication venues, highlighting areas of ongoing interest and influence. Frequent venues of publication include Atherosclerosis, Cardiovascular Research, Arteriosclerosis Thrombosis and Vascular Biology, bioRxiv (Cold Spring Harbor Laboratory), and Frontiers in Immunology.

Best Publications

  • Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

    Edwin S. Van Amersfoort;Theo J. C. Van Berkel;Johan Kuiper

  • The influence of cytokines on the integrity of the blood-brain barrier in vitro

    Helga E. de Vries;Margret C.M. Blom-Roosemalen;Marijke van Oosten;Albert G. de Boer

  • The Blood-Brain Barrier in Neuroinflammatory Diseases

    Helga E. de Vries;Johan Kuiper;Albertus G. de Boer;Theo J. C. Van Berkel

  • Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

    Marie A.C. Depuydt;Koen H.M. Prange;Lotte Slenders;Tiit Örd

  • Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential

    Jan H. Von der Thüsen;Johan Kuiper;Theo J. C. Van Berkel;Erik A. L. Biessen

  • NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report.

    Thomas van der Heijden;Eva Kritikou;Wouter Venema;Janine van Duijn

  • Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting.

    Patrick C.N Rensen;Remco L.A de Vrueh;Johan Kuiper;Martin K Bijsterbosch

  • The peripheral blood mononuclear cell microRNA signature of coronary artery disease

    Menno Hoekstra;Christian A.C. van der Lans;Bente Halvorsen;Lars Gullestad

  • Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studies.

    H. Maxime Lagraauw;Johan Kuiper;Ilze Bot

  • Blockade of Interleukin-12 Function by Protein Vaccination Attenuates Atherosclerosis

    A.D. Hauer;C. Uyttenhove;P. de Vos;V. Stroobant

  • Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels

    Ruud Out;Menno Hoekstra;Kim Habets;Illiana Meurs

  • Atherosclerosis: the interplay between lipids and immune cells

    Frank Schaftenaar;Vanessa Frodermann;Johan Kuiper;Esther Lutgens

  • Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines.

    Naomi Benne;Janine van Duijn;Johan Kuiper;Wim Jiskoot

  • Induction of Oral Tolerance to Oxidized Low-Density Lipoprotein Ameliorates Atherosclerosis

    G.H.M. van Puijvelde;A.D. Hauer;P. de Vos;R. van den Heuvel

  • Attenuation of atherogenesis by systemic and local adenovirus-mediated gene transfer of interleukin-10 in LDLr -/- Mice

    Jan H. von der Thüsen;Johan Kuiper;Madelon L. Fekkes;Paula de Vos

  • Induction of Oral Tolerance to HSP60 or an HSP60-Peptide Activates T Cell Regulation and Reduces Atherosclerosis

    G.H.M. van Puijvelde;T. van Es;E.J.A. van Wanrooij;K.L.L. Habets

  • Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis.

    M Van Oosten;P C Rensen;E S Van Amersfoort;M Van Eck

  • Treating Atherosclerosis With Regulatory T Cells

    Amanda C. Foks;Andrew H. Lichtman;Johan Kuiper

  • Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice.

    T. van Es;G.H.M. van Puijvelde;O.H. Ramos;F.M.E. Segers

  • Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

    Edwin S. Van Amersfoort;Theo J. C. Van Berkel;Johan Kuiper

Frequent Co-Authors

Theo J.C. Van Berkel
Theo J.C. Van Berkel Leiden University
Erik A.L. Biessen
Erik A.L. Biessen Maastricht University
Paul H.A. Quax
Paul H.A. Quax Leiden University Medical Center
René E. M. Toes
René E. M. Toes Leiden University Medical Center
Gerard Pasterkamp
Gerard Pasterkamp Utrecht University
Wim Jiskoot
Wim Jiskoot Leiden University
J. Wouter Jukema
J. Wouter Jukema Leiden University Medical Center
Christoph J. Binder
Christoph J. Binder Medical University of Vienna
Hideo Yagita
Hideo Yagita Juntendo University

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