World's Best Scientists 2026 revealed!
Alain Tedgui

Alain Tedgui

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Medicine
France
2023

D-Index & Metrics

Medicine

D-Index
123
Citations
54544
World Ranking
3359
National Ranking
93

Research.com Recognitions

  • 2023 - Research.com Medicine in France Leader Award
  • 2018 - Grand prix de l'Inserm - Institut national de la santé et de la recherche médicale

Overview

Alain Tedgui is affiliated with Inserm in France and has contributed extensively to the fields of medicine and immunology and microbiology. Their research spans multiple subfields, including immunology, epidemiology, molecular biology, cardiology and cardiovascular medicine, and surgery. The scientist's work focuses on several main topics such as atherosclerosis and cardiovascular diseases, adipokines, inflammation, and metabolic diseases, immune cells in cancer, lipoproteins and cardiovascular health, inflammasome and immune disorders, cardiac fibrosis and remodeling, and tryptophan and brain disorders.

The scientist has published significantly in several venues, primarily:

  • Nature Communications (6 publications)
  • médecine/sciences (3 publications)
  • Annals of Intensive Care (2 publications)
  • Nature (2 publications)
  • Archives of cardiovascular diseases (2 publications)

Frequently collaborating with several researchers, Alain Tedgui has coauthored multiple works with:

  • Hafid Ait-Oufella (22 joint publications)
  • Soraya Taleb (14 joint publications)
  • Ludivine Laurans (13 joint publications)
  • Ziad Mallat (12 joint publications)
  • Marie Vandestienne (10 joint publications)

Some recent papers attributable to the scientist's research include:

  • "Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society," 2020, Journal of Hypertension
  • "Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling," 2021, Nature Communications
  • "Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients," 2021, Annals of Intensive Care
  • "Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function After Myocardial Infarction Through Kynurenine," 2020, Circulation
  • "TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm," 2020, Journal of Clinical Investigation

Alain Tedgui was awarded the Grand prix de l'Inserm by the Institut national de la santé et de la recherche médicale in 2018.

Best Publications

  • Cytokines in atherosclerosis: pathogenic and regulatory pathways.

    Alain Tedgui;Ziad Mallat

  • Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells Physiological and Therapeutic Perspectives

    Valérie Planat-Benard;Jean-Sébastien Silvestre;Béatrice Cousin;Mireille André

  • Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

    Bart Staels;Wolfgang Koenig;Aïda Habib;Régine Merval

  • Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

    Philippe Delerive;Karolien De Bosscher;Sandrine Besnard;Wim Vanden Berghe

  • Natural regulatory T cells control the development of atherosclerosis in mice.

    Hafid Ait-Oufella;Benoît L Salomon;Stéphane Potteaux;Anna-Karin L Robertson

  • Protective role of interleukin-10 in atherosclerosis

    Ziad Mallat;Sandrine Besnard;Micheline Duriez;Virginie Deleuze

  • Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes.

    Z Mallat;H Benamer;B Hugel;J Benessiano

  • Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability

    Ziad Mallat;Anne Corbaz;Alexandra Scoazec;Sandrine Besnard

  • Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques A Role for Apoptosis in Plaque Thrombogenicity

    Ziad Mallat;Bénédicte Hugel;Jeanny Ohan;Guy Lesèche

  • Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

    Christophe Combadière;Stéphane Potteaux;Mathieu Rodero;Tabassome Simon

  • Anti-inflammatory mechanisms in the vascular wall.

    Alain Tedgui;Ziad Mallat

  • Recent Advances on the Role of Cytokines in Atherosclerosis

    Hafid Ait-Oufella;Soraya Taleb;Ziad Mallat;Alain Tedgui

  • Inhibition of Transforming Growth Factor-β Signaling Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Mice

    Ziad Mallat;Andrea Gojova;Carmen Marchiol-Fournigault;Bruno Esposito

  • Circulating Endothelial Microparticles Are Associated with Vascular Dysfunction in Patients with End-Stage Renal Failure

    Nicolas Amabile;Alain P. Guérin;Aurélie Leroyer;Ziad Mallat

  • Elevated levels of 8-iso-prostaglandin F2alpha in pericardial fluid of patients with heart failure: a potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure.

    Ziad Mallat;Ivan Philip;Maryline Lebret;Didier Chatel

  • Circulating Microparticles From Patients With Myocardial Infarction Cause Endothelial Dysfunction

    Chantal M. Boulanger;Alexandra Scoazec;Talin Ebrahimian;Patrick Henry

  • Molecular mechanisms of the vascular responses to haemodynamic forces.

    S. Lehoux;Y. Castier;A. Tedgui

  • Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice

    Christophe Combadière;Stéphane Potteaux;Ji-Liang Gao;Bruno Esposito

  • Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia

    Ziad Mallat;Alain Tedgui;Fabrice Fontaliran;Robert Frank

  • CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated Receptors

    Giulia Chinetti;Franck G. Gbaguidi;Sabine Griglio;Ziad Mallat

Frequent Co-Authors

Ziad Mallat
Ziad Mallat University of Cambridge
Tabassome Simon
Tabassome Simon Université Paris Cité
Bart Staels
Bart Staels University of Lille
Nicolas Danchin
Nicolas Danchin Université Paris Cité
Christophe Combadière
Christophe Combadière Sorbonne University
Patrick Bruneval
Patrick Bruneval Grenoble Alpes University
Christoph J. Binder
Christoph J. Binder Medical University of Vienna
Jean-Marie Freyssinet
Jean-Marie Freyssinet University of Strasbourg
Jean Mariani
Jean Mariani Sorbonne University

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