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Biology and Biochemistry

D-Index
83
Citations
22541
World Ranking
3544
National Ranking
87

Overview

Patrick C. N. Rensen is affiliated with Leiden University Medical Center in the Netherlands. Their research spans a considerable body of work in medicine and biochemistry, genetics, and molecular biology, with a focus on physiology, molecular biology, endocrinology, diabetes and metabolism, epidemiology, and surgery.

The main topics addressed in their work include adipose tissue and metabolism, diet and metabolism studies, liver disease diagnosis and treatment, circadian rhythm and melatonin, diabetes, cardiovascular risks and lipoproteins, lipid metabolism and disorders, as well as adipokines, inflammation, and metabolic diseases.

Frequent publication venues for Rensen's research are:

  • Atherosclerosis
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cardiovascular Research
  • Journal of Lipid Research
  • Frontiers in Endocrinology

Prominent co-authors with whom Rensen has collaborated frequently include:

  • Sander Kooijman
  • Mariëtte R. Boon
  • Milena Schönke
  • Borja Martínez-Téllez
  • Ko Willems van Dijk

Among their recent papers are the following:

  • "Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation" (2020), published in Cell Metabolism
  • "Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis" (2021), published in Cell
  • "Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis" (2020), published in Circulation
  • "Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial" (2022), published in Cell Reports Medicine
  • "Protective role of chaperone-mediated autophagy against atherosclerosis" (2022), published in Proceedings of the National Academy of Sciences

Best Publications

  • Inflammasome is a central player in the induction of obesity and insulin resistance

    Rinke Stienstra;Janna A. Van Diepen;Cees J. Tack;Hasan Zaki

  • The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

    Rinke Stienstra;Leo A B Joosten;Tim Koenen;Berry Van Tits

  • Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.

    Jimmy F. P. Berbée;Mariëtte R Boon;P. Padmini S. J. Khedoe;Alexander Bartelt

  • ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis.

    Frank G. Schaap;Patrick C.N. Rensen;Peter J. Voshol;Carlos Vrins

  • Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis.

    Janna A. van Diepen;Jimmy F.P. Berbée;Jimmy F.P. Berbée;Louis M. Havekes;Patrick C.N. Rensen

  • Cholesteryl Ester Transfer Protein Decreases High-Density Lipoprotein and Severely Aggravates Atherosclerosis in APOE*3-Leiden Mice

    Marit Westerterp;Caroline C van der Hoogt;Willeke de Haan;Erik H Offerman

  • Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting.

    Patrick C.N Rensen;Remco L.A de Vrueh;Johan Kuiper;Martin K Bijsterbosch

  • Cryo-electron microscopy of extracellular vesicles in fresh plasma.

    Yuana Yuana;Roman I. Koning;Maxim E. Kuil;Patrick C. N. Rensen

  • Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo.

    Patrick C.N. Rensen;Leo A.J.M. Sliedregt;Michiel Ferns;Erwin Kieviet

  • Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

    Denis P. Blondin;Denis P. Blondin;Soren Nielsen;Eline N. Kuipers;Mai C. Severinsen

  • Niacin Increases HDL by Reducing Hepatic Expression and Plasma Levels of Cholesteryl Ester Transfer Protein in APOE*3Leiden.CETP Mice

    José W.A. van der Hoorn;Willeke de Haan;Jimmy F.P. Berbée;Louis M. Havekes

  • Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis.

    M Van Oosten;P C Rensen;E S Van Amersfoort;M Van Eck

  • Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo

    P. C. N. Rensen;N. Herijgers;M. H. Netscher;S. C. J. Meskers

  • Selective liver targeting of antivirals by recombinant chylomicrons--a new therapeutic approach to hepatitis B.

    Rensen Pc;van Dijk Mc;Havenaar Ec;Bijsterbosch Mk

  • Angptl4 Upregulates Cholesterol Synthesis in Liver via Inhibition of LPL- and HL-Dependent Hepatic Cholesterol Uptake

    Laeticia Lichtenstein;Jimmy F.P. Berbée;Susan J. van Dijk;Ko Willems van Dijk

  • Brown adipose tissue takes up plasma triglycerides mostly after lipolysis.

    P. Padmini S. J. Khedoe;Geerte Hoeke;Sander Kooijman;Wieneke Dijk

  • Design and synthesis of novel amphiphilic dendritic galactosides for selective targeting of liposomes to the hepatic asialoglycoprotein receptor.

    L. A. J. M. Sliedregt;P. C. N. Rensen;E. T. Rump;P. J. Van Santbrink

  • Thyroid Hormone Effects on Whole-Body Energy Homeostasis and Tissue-Specific Fatty Acid Uptake in Vivo

    Lars P. Klieverik;Claudia P. Coomans;Erik Endert;Hans P. Sauerwein

  • Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice.

    Miek C. Jong;Patrick C.N. Rensen;Vivian E.H. Dahlmans;Hans van der Boom

  • Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis

    Geerte Hoeke;Sander Kooijman;Mariëtte R. Boon;Patrick C.N. Rensen

Frequent Co-Authors

Louis M. Havekes
Louis M. Havekes Leiden University Medical Center
Ko Willems van Dijk
Ko Willems van Dijk Leiden University Medical Center
Johannes A. Romijn
Johannes A. Romijn University of Amsterdam
Johannes W. A. Smit
Johannes W. A. Smit Leiden University Medical Center
J. Wouter Jukema
J. Wouter Jukema Leiden University Medical Center
Hans M.G. Princen
Hans M.G. Princen Netherlands Organisation for Applied Scientific Research
Theo J.C. Van Berkel
Theo J.C. Van Berkel Leiden University
Frits R. Rosendaal
Frits R. Rosendaal Leiden University Medical Center
Diana van Heemst
Diana van Heemst Leiden University Medical Center
Onno C. Meijer
Onno C. Meijer Leiden University Medical Center

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