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Biology and Biochemistry

D-Index
85
Citations
20774
World Ranking
3211
National Ranking
81

Overview

Helga E. de Vries is affiliated with the University of Amsterdam in the Netherlands and has an extensive publication record in the fields of medicine, neuroscience, and biochemistry, genetics, and molecular biology. Their research encompasses a range of subfields, including neurology, molecular biology, immunology, physiology, and pathology and forensic medicine.

Their work covers several main research topics, notably:

  • Neuroinflammation and neurodegeneration mechanisms
  • Multiple sclerosis research studies
  • Alzheimer's disease research and treatments
  • Sphingolipid metabolism and signaling
  • Barrier structure and function studies
  • Immune cell function and interaction
  • Neurogenesis and neuroplasticity mechanisms

Among their recent published papers are:

  • "Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages," 2020, Metabolites
  • "Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques," 2020, Nature Communications
  • "Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells," 2020, Acta Neuropathologica Communications
  • "Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex," 2022, Nature Neuroscience
  • "Sphingolipids in Alzheimer's disease, how can we target them?", 2020, Advanced Drug Delivery Reviews

Frequent collaborators include Gijs Kooij, Alwin Kamermans, Carla Rodriguez-Mogeda, Susanne M. A. van der Pol, and Lynn van Olst, reflecting a collaborative research environment with multiple co-authored studies.

De Vries has published multiple times in prominent venues such as:

  • Journal of Neuroinflammation
  • Acta Neuropathologica Communications
  • Acta Neuropathologica
  • Fluids and Barriers of the CNS
  • Alzheimer's & Dementia

The diversity of publication venues illustrates de Vries's interdisciplinary approach, integrating knowledge from neuropathology, immunology, and neurodegenerative disease research. Their contributions span both basic and translational science, focusing on cellular and molecular mechanisms related to inflammation, immune response, and neurological disease processes.

Best Publications

  • The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

    Jorge Ivan Alvarez;Aurore Dodelet-Devillers;Hania Kebir;Igal Ifergan

  • The Blood-Brain Barrier in Neuroinflammatory Diseases

    Helga E. de Vries;Johan Kuiper;Albertus G. de Boer;Theo J. C. Van Berkel

  • Nrf2-induced antioxidant protection : A promising target to counteract ROS-mediated damage in neurodegenerative disease?

    Helga E. de Vries;Maarten Witte;David Hondius;Annemieke J.M. Rozemuller

  • Radical changes in multiple sclerosis pathogenesis.

    Jack van Horssen;Maarten E. Witte;Gerty Schreibelt;Helga E. de Vries

  • Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

    Gerty Schreibelt;Gijs Kooij;Arie Reijerkerk;Ruben van Doorn

  • The blood-brain barrier and its role in immune privilege in the central nervous system.

    Joel S Pachter;Helga E de Vries;Zsuzsa Fabry

  • Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?

    Maarten E. Witte;Jeroen J.G. Geurts;Helga E. de Vries;Paul van der Valk

  • Macrophages and neurodegeneration

    Jerome J.A. Hendriks;Charlotte E. Teunissen;Helga E. de Vries;Christine D. Dijkstra

  • Amyloid Beta Induces Oxidative Stress-Mediated Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy

    Anna Carrano;Jeroen J.M. Hoozemans;Saskia M. van der Vies;Annemieke J.M. Rozemuller

  • MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

    Miguel Alejandro Lopez-Ramirez;Dongsheng Wu;Gareth Pryce;Julie E. Simpson

  • Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke.

    Melissa A. Lopes Pinheiro;Gijs Kooij;Mark R. Mizee;Alwin Kamermans

  • Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101).

    Pieter J. Gaillard;Chantal C. M. Appeldoorn;Rick Dorland;Joan van Kregten

  • Interferon-β directly influences monocyte infiltration into the central nervous system

    Sarah Floris;Sigrid R. Ruuls;Anne Wierinckx;Susanne M.A. van der Pol

  • Enhanced number and activity of mitochondria in multiple sclerosis lesions.

    Maarten E Witte;Lars Bø;Richard J Rodenburg;Jeroen A Belien

  • Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement.

    Machteld M. Vellinga;Raoul D. Oude Engberink;Alexandra Seewann;Petra J. W. Pouwels

  • The Blood-Brain Barrier in Cortical Multiple Sclerosis Lesions

    Jack van Horssen;Bianca P Brink;Helga E de Vries;Paul van der Valk

  • Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis.

    Jerome J.A. Hendriks;Jacqueline Alblas;Susanne M.A. van der Pol;Eric A.F. van Tol

  • Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis.

    Catharina M.P. Vos;Jeroen J.G. Geurts;Lisette Montagne;Elise S. van Haastert

  • Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

    Erwin A. van Vliet;Grazia Forte;Linda Holtman;Jeroen C. G. den Burger

  • Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions.

    Ruben Van Doorn;Jack Van Horssen;Dennis Verzijl;Maarten Witte

Frequent Co-Authors

Jack van Horssen
Jack van Horssen Vrije Universiteit Amsterdam
Christine D. Dijkstra
Christine D. Dijkstra VU University Medical Center
Paul van der Valk
Paul van der Valk Vrije Universiteit Amsterdam
Sandra Amor
Sandra Amor University of Amsterdam
Ignacio A. Romero
Ignacio A. Romero The Open University
Dirk Geerts
Dirk Geerts University of Amsterdam
Gerty Schreibelt
Gerty Schreibelt Radboud University
Johan Kuiper
Johan Kuiper Leiden University
Theo J.C. Van Berkel
Theo J.C. Van Berkel Leiden University
Denis Vivien
Denis Vivien Université de Caen Normandie

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