H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 54 Citations 11,196 139 World Ranking 7874 National Ranking 185

Overview

What is she best known for?

The fields of study she is best known for:

  • Enzyme
  • Internal medicine
  • Inflammation

Helga E. de Vries spends much of her time researching Blood–brain barrier, Multiple sclerosis, Pathology, Immunology and Cell biology. The concepts of her Blood–brain barrier study are interwoven with issues in Inflammation, Immune system, Encephalomyelitis, Endothelium and Tight junction. Her Multiple sclerosis research includes elements of Lesion, Neuroinflammation, Neuroscience and Reactive oxygen species.

Her Neuroinflammation study deals with Neurodegeneration intersecting with Mitochondrion. Her Pathology research is multidisciplinary, incorporating elements of Laminin and White matter, Magnetic resonance imaging. Her research in Cell biology intersects with topics in Endothelial stem cell, Cell migration and Cell adhesion.

Her most cited work include:

  • The influence of cytokines on the integrity of the blood-brain barrier in vitro (499 citations)
  • The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence (463 citations)
  • The Blood-Brain Barrier in Neuroinflammatory Diseases (365 citations)

What are the main themes of her work throughout her whole career to date?

Multiple sclerosis, Blood–brain barrier, Immunology, Neuroinflammation and Cell biology are her primary areas of study. Her studies deal with areas such as Inflammation, Central nervous system, Neuroscience and Pathology as well as Multiple sclerosis. Her study focuses on the intersection of Pathology and fields such as In vivo with connections in the field of In vitro.

Her studies in Blood–brain barrier integrate themes in fields like Basement membrane, Barrier function, Tight junction, Pharmacology and Epilepsy. Her work deals with themes such as Reactive oxygen species and Microglia, which intersect with Neuroinflammation. As a part of the same scientific family, Helga E. de Vries mostly works in the field of Cell biology, focusing on Endothelial stem cell and, on occasion, Human brain.

She most often published in these fields:

  • Multiple sclerosis (42.64%)
  • Blood–brain barrier (35.53%)
  • Immunology (28.43%)

What were the highlights of her more recent work (between 2018-2021)?

  • Multiple sclerosis (42.64%)
  • Inflammation (24.37%)
  • Neuroinflammation (26.40%)

In recent papers she was focusing on the following fields of study:

Helga E. de Vries mainly investigates Multiple sclerosis, Inflammation, Neuroinflammation, Cell biology and Central nervous system. Her Multiple sclerosis research incorporates themes from Myelin, Phagocyte, Neuroprotection and In vivo. Her study on Inflammation is covered under Immunology.

The Neuroinflammation study combines topics in areas such as Sphingolipid, Neurodegeneration, Microglia, Experimental autoimmune encephalomyelitis and Neuroscience. Her Cell biology study combines topics in areas such as Lipoprotein lipase, Blood–brain barrier and Metabotropic receptor. Helga E. de Vries has researched Central nervous system in several fields, including In vitro, Cerebrospinal fluid, Transient receptor potential channel and Chondroitin sulfate proteoglycan.

Between 2018 and 2021, her most popular works were:

  • Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction (22 citations)
  • Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model. (15 citations)
  • Sphingolipids in Alzheimer's disease, how can we target them? (15 citations)

In her most recent research, the most cited papers focused on:

  • Enzyme
  • Internal medicine
  • Biochemistry

Helga E. de Vries mainly focuses on Multiple sclerosis, Cell biology, Central nervous system, Neurodegeneration and Inflammation. Multiple sclerosis is a subfield of Immunology that Helga E. de Vries explores. Her research in Cell biology intersects with topics in Endothelial stem cell and Neuroprotection.

The Central nervous system study combines topics in areas such as TRPM7, Transient receptor potential channel, In vitro and Chondroitin sulfate proteoglycan. In her study, Tight junction, Endothelium, Knockout mouse and Progressive supranuclear palsy is inextricably linked to Neuroinflammation, which falls within the broad field of Neurodegeneration. Her work deals with themes such as Stromal cell, Cerebrospinal fluid and CD8, Immune system, which intersect with Inflammation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The influence of cytokines on the integrity of the blood-brain barrier in vitro

Helga E. de Vries;Margret C.M. Blom-Roosemalen;Marijke van Oosten;Albert G. de Boer.
Journal of Neuroimmunology (1996)

771 Citations

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

Jorge Ivan Alvarez;Aurore Dodelet-Devillers;Hania Kebir;Igal Ifergan.
Science (2011)

578 Citations

The Blood-Brain Barrier in Neuroinflammatory Diseases

Helga E. de Vries;Johan Kuiper;Albertus G. de Boer;Theo J. C. Van Berkel.
Pharmacological Reviews (1997)

567 Citations

Nrf2-induced antioxidant protection : A promising target to counteract ROS-mediated damage in neurodegenerative disease?

Helga E. de Vries;Maarten Witte;David Hondius;Annemieke J.M. Rozemuller.
Free Radical Biology and Medicine (2008)

477 Citations

The blood-brain barrier and its role in immune privilege in the central nervous system.

Joel S Pachter;Helga E de Vries;Zsuzsa Fabry.
Journal of Neuropathology and Experimental Neurology (2003)

345 Citations

Radical changes in multiple sclerosis pathogenesis.

Jack van Horssen;Maarten E. Witte;Gerty Schreibelt;Helga E. de Vries.
Biochimica et Biophysica Acta (2011)

341 Citations

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

Gerty Schreibelt;Gijs Kooij;Arie Reijerkerk;Ruben van Doorn.
The FASEB Journal (2007)

317 Citations

Macrophages and neurodegeneration

Jerome J.A. Hendriks;Charlotte E. Teunissen;Helga E. de Vries;Christine D. Dijkstra.
Brain Research Reviews (2005)

289 Citations

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

Maarten E. Witte;Jeroen J.G. Geurts;Helga E. de Vries;Paul van der Valk.
Mitochondrion (2010)

260 Citations

Interferon-β directly influences monocyte infiltration into the central nervous system

Sarah Floris;Sigrid R. Ruuls;Anne Wierinckx;Susanne M.A. van der Pol.
Journal of Neuroimmunology (2002)

233 Citations

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