Niels Hellings

Overview

Best Publications

• Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level.

  Koen Venken;Niels Hellings;Marielle Thewissen;Veerle Somers

  476
  Citations

• Systemic immune activation leads to neuroinflammation and sickness behavior in mice.

  Steven Biesmans;Theo F. Meert;Jan A. Bouwknecht;Paul D. Acton

  427
  Citations

• Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression.

  Koen Venken;Niels Hellings;Tom Broekmans;Karen Hensen

  347
  Citations

• Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression

  Koen Venken;Niels Hellings;Karen Hensen;Jean-Luc Rummens

  270
  Citations

• CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation.

  Marielle Thewissen;Veerle Somers;Niels Hellings;Judith Fraussen

  258
  Citations

• Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

  Nele Claes;Judith Fraussen;Marjan Vanheusden;Niels Hellings

  224
  Citations

• T‐cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls

  Niels Hellings;Mark Baree;Christof Verhoeven;Marie Beatrijs D'hooghe

  197
  Citations

• Disturbed regulatory T cell homeostasis in multiple sclerosis.

  Koen Venken;Koen Venken;Niels Hellings;Roland Liblau;Piet Stinissen

  191
  Citations

• A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses

  Koen Venken;Marielle Thewissen;Niels Hellings;Veerle Somers

  188
  Citations

• Characterization of three human oligodendroglial cell lines as a model to study oligodendrocyte injury: morphology and oligodendrocyte-specific gene expression.

  Mieke Buntinx;Joris Vanderlocht;Niels Hellings;Frank Vandenabeele

  152
  Citations

• CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients

  Bieke Broux;Kim Pannemans;Xin Zhang;Silva Markovic-Plese

  148
  Citations

• Pathogenic features of CD4+CD28- T cells in immune disorders.

  Bieke Broux;Silva Markovic-Plese;Piet Stinissen;Niels Hellings

  139
  Citations

• Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis

  Tessa Dhaeze;Evelyn Peelen;Anneleen Hombrouck;Liesbet Peeters

  134
  Citations

• Insights into the immunopathogenesis of multiple sclerosis.

  Niels Hellings;Jef Raus;Piet Stinissen

  125
  Citations

• Human Wharton's Jelly-Derived Stem Cells Display a Distinct Immunomodulatory and Proregenerative Transcriptional Signature Compared to Bone Marrow-Derived Stem Cells

  Raf Donders;Jeroen F J Bogie;Stylianos Ravanidis;Pascal Gervois

  123
  Citations

• High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System

  Silke Timmermans;Jeroen F. J. Bogie;Tim Vanmierlo;Dieter Lütjohann

  109
  Citations

• Myelin alters the inflammatory phenotype of macrophages by activating PPARs

  Jeroen F J Bogie;Winde Jorissen;Jo Mailleux;Philip G Nijland

  107
  Citations

• Human Wharton's Jelly-Derived Stem Cells Display Immunomodulatory Properties and Transiently Improve Rat Experimental Autoimmune Encephalomyelitis.

  Raf Donders;Marjan Vanheusden;Jeroen F. J. Bogie;Stylianos Ravanidis

  106
  Citations

• Glycine and glycine receptor signalling in non-neuronal cells.

  Jimmy Van den Eynden;Sheen Saheb Ali;Nikki Horwood;Sofi e Carmans

  102
  Citations

• Compositional Changes of B and T Cell Subtypes during Fingolimod Treatment in Multiple Sclerosis Patients: A 12-Month Follow-Up Study

  Nele Claes;Tessa Dhaeze;Judith Fraussen;Bieke Broux

  93
  Citations

• Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS).

  Mirre De Bondt;Mirre De Bondt;Niels Hellings;Ghislain Opdenakker;Sofie Struyf

  91
  Citations

• CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation

  Marielle Thewissen;Veerle Somers;Niels Heltings;Piet Stinissen

  2
  Citations