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Veerle Baekelandt

Veerle Baekelandt

D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
19180
World Ranking
5344
National Ranking
84

Overview

Veerle Baekelandt is affiliated with KU Leuven in Belgium and has contributed extensively to research in medicine, biochemistry, genetics, molecular biology, and neuroscience. Their work spans a broad range of topics related to neurological disorders, with a particular focus on Parkinson's disease mechanisms, lysosomal storage disorders, and neuroinflammation.

The main fields of study associated with Baekelandt's research are:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these areas, notable subfields include neurology, molecular biology, physiology, cellular and molecular neuroscience, and epidemiology.

  • Neurology
  • Molecular Biology
  • Physiology
  • Cellular and Molecular Neuroscience
  • Epidemiology

Major research topics covered are related to Parkinson's disease mechanisms and treatments, lysosomal storage disorders research, autophagy in disease and therapy, cellular transport and secretion, neurological diseases and metabolism, polyamine metabolism and applications, and neuroinflammation and neurodegeneration mechanisms.

  • Parkinson's Disease Mechanisms and Treatments
  • Lysosomal Storage Disorders Research
  • Autophagy in Disease and Therapy
  • Cellular transport and secretion
  • Neurological diseases and metabolism
  • Polyamine Metabolism and Applications
  • Neuroinflammation and Neurodegeneration Mechanisms

Frequent co-authors include:

  • Chris Van den Haute
  • Peter Vangheluwe
  • Evy Lobbestael
  • Jan Eggermont
  • Shaun Martin

Veerle Baekelandt has published numerous articles in various scientific venues. The most common publication outlets are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica
  • Frontiers in Neuroscience
  • Proceedings of the National Academy of Sciences
  • International Journal of Molecular Sciences

Some of Baekelandt's recent papers include:

  • ATP13A2 deficiency disrupts lysosomal polyamine export (2020, Nature)
  • The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies (2020, Acta Neuropathologica)
  • ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress (2020, Proceedings of the National Academy of Sciences)
  • ATP13A3 is a major component of the enigmatic mammalian polyamine transport system (2020, Journal of Biological Chemistry)
  • Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation (2020, Frontiers in Neuroscience)

Best Publications

  • α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

    W. Peelaerts;L. Bousset;A. Van der Perren;A. Moskalyuk

  • Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

    Dieder Moechars;Ilse Dewachter;Kristin Lorent;Delphine Reversé

  • Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

    An Herreman;Dieter Hartmann;Wim Annaert;Paul Saftig

  • Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

    Sebastiaan De Schepper;Simon Verheijden;Javier Aguilera-Lizarraga;Maria Francesca Viola

  • Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

    A. Beilina;I. N. Rudenko;A. Kaganovich;L. Civiero

  • The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

    Elisa Greggio;Ibardo Zambrano;Alice Kaganovich;Alexandra Beilina

  • Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

    Loukia Parisiadou;Chengsong Xie;Hyun Jin Cho;Xian Lin

  • Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.

    Géraldine Gelders;Veerle Baekelandt;Anke Van der Perren

  • Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain.

    Jean-Marc Taymans;Luk H Vandenberghe;Chris Van Den Haute;Irina Thiry

  • Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.

    Amanda Sierra;Amanda Sierra;Soraya Martín-Suárez;Roberto Valcárcel-Martín;Jesús Pascual-Brazo

  • MicroRNA-205 regulates the Expression of Parkinson’s disease-related Leucine-rich Repeat Kinase 2 Protein

    Hyun Jin Cho;Guoxiang Liu;Seok Min Jin;Loukia Parisiadou

  • Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

    Fabienne C Fiesel;Aaron Voigt;Stephanie S Weber;Chris Van den Haute

  • ATP13A2 deficiency disrupts lysosomal polyamine export

    Sarah van Veen;Shaun Martin;Chris Van den Haute;Veronick Benoy

  • rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

    Marusela Oliveras-Salvá;Anke Van der Perren;Nicolas Casadei;Stijn Stroobants

  • Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

    Q Remijsen;V Goossens;S Grootjans;C Van den Haute

  • Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

    Bavo Heeman;Chris Van den Haute;Sarah-Ann Aelvoet;Federica Valsecchi

  • Distribution of PINK1 and LRRK2 in rat and mouse brain.

    Jean-Marc Taymans;Chris Van den Haute;Veerle Baekelandt

  • The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

    Anke Van der Perren;Géraldine Gelders;Alexis Fenyi;Luc Bousset

  • Comparison of lentiviral vector titration methods.

    Martine Geraerts;Sofie Willems;Veerle Baekelandt;Zeger Debyser

  • Upscaling of lentiviral vector production by tangential flow filtration

    Martine Geraerts;Martine Michiels;Veerle Baekelandt;Zeger Debyser

Frequent Co-Authors

Zeger Debyser
Zeger Debyser KU Leuven
Rik Gijsbers
Rik Gijsbers KU Leuven
Mark R. Cookson
Mark R. Cookson National Institutes of Health
Bart Nuttin
Bart Nuttin KU Leuven
Lieve Moons
Lieve Moons KU Leuven
Paul Boon
Paul Boon Ghent University
Kristl Vonck
Kristl Vonck Ghent University

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