Dario R. Alessi

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2022 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2008 - Fellow of the Royal Society, United Kingdom
• 2002 - Fellow of the Royal Society of Edinburgh
• Member of the European Molecular Biology Organization (EMBO)
• Fellow of The Academy of Medical Sciences, United Kingdom
• Member of the European Molecular Biology Organization (EMBO)
• Fellow of The Academy of Medical Sciences, United Kingdom
• Member of the European Molecular Biology Organization (EMBO)
• Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Best Publications

• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.

  Darren A. E. Cross;Dario R. Alessi;Philip Cohen;Mirjana Andjelkovich

  6575
  Citations

• PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

  Dario R. Alessi;Ana Cuenda;Philip Cohen;David T. Dudley

  4160
  Citations

• Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

  Dario R. Alessi;Stephen R. James;C.Peter Downes;Andrew B. Holmes

  3913
  Citations

• Mechanism of activation of protein kinase B by insulin and IGF-1.

  Dario R. Alessi;Mirjana Andjelkovic;Barry Caudwell;Peter Cron

  3814
  Citations

• The selectivity of protein kinase inhibitors: a further update.

  Jenny Bain;Lorna Plater;Matt Elliott;Natalia Shpiro

  2992
  Citations

• Metformin and reduced risk of cancer in diabetic patients

  Josie M M Evans;Louise A Donnelly;Alistair M Emslie-Smith;Dario R Alessi

  2914
  Citations

• The PI3K-PDK1 connection: more than just a road to PKB.

  Bart Vanhaesebroeck;Dario R. Alessi

  2178
  Citations

• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  Simon A Hawley;Jérôme Boudeau;Jennifer L Reid;Kirsty J Mustard

  2058
  Citations

• LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

  Jose M Lizcano;Olga Göransson;Rachel Toth;Maria Deak

  1558
  Citations

• The nuts and bolts of AGC protein kinases

  Laura R. Pearce;David Komander;Dario R. Alessi

  1547
  Citations

• PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

  Margaret A. Lawlor;Dario R. Alessi

  1514
  Citations

• Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

  J. Ann Le Good;Wolfgang H. Ziegler;Davey B. Parekh;Dario R. Alessi

  1435
  Citations

• Role of Translocation in the Activation and Function of Protein Kinase B

  Mirjana Andjelkovic;Dario R. Alessi;Roger Meier;Anne Fernandez

  1380
  Citations

• Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

  Barbara T. Navé;D. Margriet Ouwens;Dominic J. Withers;Dario R. Alessi

  1367
  Citations

• New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

  Gillian Libby;Louise A. Donnelly;Peter T. Donnan;Dario R. Alessi;Dario R. Alessi

  1318
  Citations

• Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

  Maria Deak;Andrew D. Clifton;John M. Lucocq;Dario R. Alessi

  1284
  Citations

• mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

  Juan Manuel García-Martínez;Dario R Alessi

  1073
  Citations

• Mechanism of activation and function of protein kinase B.

  Dario R Alessi;Philip Cohen

  1030
  Citations

• PDK1, the master regulator of AGC kinase signal transduction.

  Alfonso Mora;David Komander;Daan M.F. van Aalten;Dario R. Alessi

  1028
  Citations

• 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

  Dario R. Alessi;Maria Deak;Antonio Casamayor;F. Barry Caudwell

  986
  Citations