World's Best Scientists 2026 revealed!
Benoit Viollet

Benoit Viollet

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Biology and Biochemistry
France
2026
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Medicine
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
125
Citations
64375
World Ranking
506
National Ranking
7

Medicine

D-Index
125
Citations
64341
World Ranking
3071
National Ranking
81

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in France Leader Award
  • 2025 - Research.com Biology and Biochemistry in France Leader Award
  • 2023 - Research.com Biology and Biochemistry in France Leader Award
  • 2023 - Research.com Medicine in France Leader Award
  • 2022 - Research.com Biology and Biochemistry in France Leader Award

Overview

Benoit Viollet is affiliated with the Institut Cochin in France and has an extensive research portfolio primarily focused on medicine, biochemistry, genetics, and molecular biology. Their work spans several interconnected fields including molecular biology, physiology, surgery, epidemiology, and endocrinology, diabetes, and metabolism.

The scientist's publications cover a broad range of topics, with prominent emphasis on metabolism, diabetes, and cancer. Other major themes include pancreatic function and diabetes, adipose tissue and metabolism, autophagy in disease and therapy, diabetes treatment and management, cancer, hypoxia, and metabolism, as well as diet and metabolism studies.

Benoit Viollet has contributed to numerous papers in various reputable publication venues. Some frequent venues for their work are:

  • Cell Biochemistry and Function (13 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (8 publications)
  • Nature Communications (4 publications)
  • Molecular Metabolism (4 publications)
  • Diabetes (3 publications)

Notable recent papers authored or co-authored by Benoit Viollet include:

  • "Metformin: update on mechanisms of action and repurposing potential," 2023, Nature Reviews Endocrinology
  • "Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy," 2022, Nature Communications
  • "Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2," 2021, Science Immunology
  • "Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise," 2020, Molecular Metabolism
  • "AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia," 2022, Cell Reports

Their frequent co-authors include:

  • Marc Foretz
  • A Pitsillides
  • Martin Hewison
  • Zane B. Andrews
  • Andrew Batchelor

Benoit Viollet's research integrates multiple approaches to understand the molecular and physiological mechanisms underlying metabolism and disease. Their work contributes to understanding the metabolic pathways involved in diabetes, cancer, and cellular bioenergetics, with implications for therapeutic interventions.

Best Publications

  • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

    Joungmok Kim;Mondira Kundu;Benoit Viollet;Kun-Liang Guan

  • Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

    Daniel F. Egan;David B. Shackelford;Maria M. Mihaylova;Sara R. Gelino

  • Cellular and molecular mechanisms of metformin: an overview

    Benoit Viollet;Benoit Viollet;Benoit Viollet;Bruno Guigas;Nieves Sanz Garcia;Nieves Sanz Garcia;Nieves Sanz Garcia;Jocelyne Leclerc;Jocelyne Leclerc;Jocelyne Leclerc

  • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

    Marc Foretz;Sophie Hébrard;Jocelyne Leclerc;Elham Zarrinpashneh

  • Metformin: From Mechanisms of Action to Therapies

    Marc Foretz;Bruno Guigas;Luc Bertrand;Michael Pollak

  • Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

    Monica Buzzai;Russell G. Jones;Ravi K. Amaravadi;Julian J. Lum

  • AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

    Brandon Faubert;Gino Boily;Said Izreig;Takla Griss

  • Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

    Russell A. Miller;Qingwei Chu;Jianxin Xie;Marc Foretz;Marc Foretz;Marc Foretz

  • Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

    Adem Kalender;Anand Selvaraj;Anand Selvaraj;So Young Kim;So Young Kim;Pawan Gulati

  • AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

    Jee Hyun Um;Sung-Jun Park;Hyeog Kang;Shutong Yang

  • Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle

    Sebastian B. Jørgensen;Benoit Viollet;Fabrizio Andreelli;Christian Frøsig

  • Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase.

    Min-Seon Kim;Joong-Yeol Park;Cherl Namkoong;Pil-Geum Jang

  • The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

    Julianna Blagih;François Coulombe;Emma E. Vincent;Fanny Dupuy

  • Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders

    Benoit Viollet;Marc Foretz;Bruno Guigas;Sandrine Horman

  • 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments.

    Keith R. Laderoute;Khalid Amin;Joy M. Calaoagan;Merrill Knapp

  • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.

    Bradley J. Davis;Zhonglin Xie;Benoit Viollet;Ming Hui Zou

  • Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

    Amy R. Cameron;Vicky L. Morrison;Daniel Levin;Mohapradeep Mohan

  • The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

    Benoit Viollet;Fabrizio Andreelli;Sebastian B. Jørgensen;Christophe Perrin

  • AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

    Marc Claret;Mark A. Smith;Rachel L. Batterham;Colin Selman

  • AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

    Benoit Viollet;Bruno Guigas;Bruno Guigas;Jocelyne Leclerc;Jocelyne Leclerc;Sophie Hébrard;Sophie Hébrard

Frequent Co-Authors

Marc Foretz
Marc Foretz Université Paris Cité
Kei Sakamoto
Kei Sakamoto University of Copenhagen
Sophie Vaulont
Sophie Vaulont Université Paris Cité
Luc Bertrand
Luc Bertrand Université Catholique de Louvain
Jørgen F. P. Wojtaszewski
Jørgen F. P. Wojtaszewski University of Copenhagen
Louis Hue
Louis Hue Université Catholique de Louvain
Ming-Hui Zou
Ming-Hui Zou Georgia State University
Jean-Louis Vanoverschelde
Jean-Louis Vanoverschelde Université Catholique de Louvain
Erik A. Richter
Erik A. Richter University of Copenhagen
Juleen R. Zierath
Juleen R. Zierath Karolinska Institute

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