World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
28384
World Ranking
2443
National Ranking
26

Overview

Kei Sakamoto is affiliated with the University of Copenhagen in Denmark and has contributed extensively to fields spanning medicine, biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, surgery, pulmonary and respiratory medicine, physiology, and infectious diseases.

Their work addresses a range of topics including metabolism, diabetes, and cancer; esophageal cancer research and treatment; pancreatic function and diabetes; esophageal and gastrointestinal pathology; gastric cancer management and outcomes; autophagy in disease and therapy; and adipose tissue and metabolism.

Kei Sakamoto has published multiple recent papers, including:

  • Real-World Evaluation of Factors for Interstitial Lung Disease Incidence and Radiologic Characteristics in Patients With EGFR T790M-positive NSCLC Treated With Osimertinib in Japan, 2020, Journal of Thoracic Oncology
  • Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965, 2021, Biochemical Journal
  • Mechanism of glycogen synthase inactivation and interaction with glycogenin, 2022, Nature Communications
  • Transcription factor EB and TFE3: new metabolic coordinators mediating adaptive responses to exercise in skeletal muscle?, 2020, American Journal of Physiology-Endocrinology and Metabolism
  • AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy, 2020, Nature Communications

Frequent co-authors include Yasukazu Kanie, Akihiko Okamura, Suguru Maruyama, Jun Kanamori, and Yu Imamura, each having collaborated with Sakamoto on numerous occasions.

Kei Sakamoto's publications often appear in notable venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Annals of Surgical Oncology
  • Nature Communications
  • Molecular Metabolism
  • World Journal of Surgery

Their research output encompasses a significant number of papers in medicine (166) and biochemistry, genetics, and molecular biology (79), reflecting a broad interdisciplinary approach that spans basic molecular mechanisms and clinical applications.

Best Publications

  • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

    Marc Foretz;Sophie Hébrard;Jocelyne Leclerc;Elham Zarrinpashneh

  • LKB1-Dependent Signaling Pathways

    Dario R Alessi;Kei Sakamoto;Jose R Bayascas

  • The ancient drug salicylate directly activates AMP-activated protein kinase

    Simon A. Hawley;Morgan D. Fullerton;Fiona A. Ross;Jonathan D. Schertzer

  • AMPK: A Key Sensor of Fuel and Energy Status in Skeletal Muscle

    D. Grahame Hardie;Kei Sakamoto

  • Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

    Edward J McManus;Kei Sakamoto;Laura J Armit;Leah Ronaldson

  • Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

    Kei Sakamoto;Afshan McCarthy;Darrin Smith;Kevin A Green

  • Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

    Amy R. Cameron;Vicky L. Morrison;Daniel Levin;Mohapradeep Mohan

  • Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

    Kei Sakamoto;Geoffrey D. Holman

  • Molecular mechanism of action of metformin: old or new insights?

    Graham Rena;Ewan R. Pearson;Kei Sakamoto

  • Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

    Olga Göransson;Andrew McBride;Simon A. Hawley;Fiona A. Ross

  • Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

    Xu Huang;Stephan Wullschleger;Natalia Shpiro;Victoria A. McGuire

  • How long does the protective effect on eccentric exercise-induced muscle damage last?

    Kazunori Nosaka;Kei Sakamoto;Mike Newton;Paul Sacco

  • AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration

    Rémi Mounier;Marine Théret;Marine Théret;Marine Théret;Ludovic Arnold;Ludovic Arnold;Sylvain Cuvellier;Sylvain Cuvellier;Sylvain Cuvellier

  • Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells.

    Farhat V.N. Din;Asta Valanciute;Vanessa P. Houde;Daria Zibrova

  • Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study.

    Apiradee Sriwijitkamol;Dawn K. Coletta;Estela Wajcberg;Gabriela B. Balbontin

  • Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle

    Henning F. Kramer;Carol A. Witczak;Nobuharu Fujii;Niels Jessen

  • Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

    Kei Sakamoto;Olga Göransson;D Grahame Hardie;Dario R Alessi

  • Invited review: intracellular signaling in contracting skeletal muscle.

    Kei Sakamoto;Laurie J. Goodyear

  • Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

    Franck Mauvais-Jarvis;Kohjiro Ueki;David A. Fruman;Michael F. Hirshman

  • Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

    Max R. Banko;Jasmina J. Allen;Bethany E. Schaffer;Erik W. Wilker

Frequent Co-Authors

Benoit Viollet
Benoit Viollet Institut Cochin
Marc Foretz
Marc Foretz Université Paris Cité
Dario R. Alessi
Dario R. Alessi University of Dundee
Laurie J. Goodyear
Laurie J. Goodyear Harvard University
Luc Bertrand
Luc Bertrand Université Catholique de Louvain
Michael F. Hirshman
Michael F. Hirshman Harvard University
Bruce E. Kemp
Bruce E. Kemp Australian Catholic University
Jean-Louis Vanoverschelde
Jean-Louis Vanoverschelde Université Catholique de Louvain
Mark Peggie
Mark Peggie University of Dundee
Gregory R. Steinberg
Gregory R. Steinberg McMaster University

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