Mark Peggie

Overview

Best Publications

• The ancient drug salicylate directly activates AMP-activated protein kinase

  Simon A. Hawley;Morgan D. Fullerton;Fiona A. Ross;Jonathan D. Schertzer

  813
  Citations

• Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.

  Kristopher Clark;Lorna Plater;Mark Peggie;Philip Cohen

  487
  Citations

• Chaperoned Ubiquitylation-Crystal Structures of the Chip U Box E3 Ubiquitin Ligase and a Chip-Ubc13-Uev1A Complex

  Minghao Zhang;Mark Windheim;S. Mark Roe;Mark Peggie

  463
  Citations

• Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

  James T. Murray;David G. Campbell;Nicholas Morrice;Gillian C. Auld

  394
  Citations

• Novel cross-talk within the IKK family controls innate immunity.

  Kristopher Clark;Mark Peggie;Lorna Plater;Ronald J. Sorcek

  355
  Citations

• Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

  Graham Rena;Yvonne L. Woods;Alan R. Prescott;Mark Peggie

  306
  Citations

• Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains

  Abdallah K. Al-Hakim;Anna Zagorska;Louise Chapman;Maria Deak

  298
  Citations

• p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP

  Guadalupe Sabio;Guadalupe Sabio;James Simon Campbell Arthur;Yvonne Kuma;Mark Peggie

  288
  Citations

• Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

  Kristopher Clark;Kirsty F. MacKenzie;Kasparas Petkevicius;Yosua Kristariyanto

  280
  Citations

• Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.

  Simon Rousseau;Nick Morrice;Mark Peggie;David G. Campbell

  274
  Citations

• Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

  Roger W. Hunter;Roger W. Hunter;Curtis C. Hughey;Louise Lantier;Elias I. Sundelin

  260
  Citations

• Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide

  Mark Windheim;Christine Lang;Mark Peggie;Lorna A. Plater

  240
  Citations

• Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

  Agne Kazlauskaite;R. Julio Martinez-Torres;Scott Wilkie;Atul Kumar

  232
  Citations

• Allosteric Regulation of Glycogen Synthase Controls Glycogen Synthesis in Muscle

  Michale Bouskila;Roger W. Hunter;Adel F.M. Ibrahim;Lucie Delattre

  222
  Citations

• Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose.

  Jean E. Harthill;Sarah E. M. Meek;Nick Morrice;Mark W. Peggie

  211
  Citations

• The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

  Alban Ordureau;Hilary Smith;Mark Windheim;Mark Peggie

  199
  Citations

• Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.

  Simon Morton;Luke Hesson;Mark Peggie;Philip Cohen

  194
  Citations

• The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

  Kashyap Patel;Marc Foretz;Allison Marion;David G. Campbell

  179
  Citations

• Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

  Yu Chiang Lai;Chandana Kondapalli;Ronny Lehneck;James B. Procter

  174
  Citations

• Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL-1 Receptor-Associated Kinase 1 To Facilitate NEMO Binding and the Activation of IκBα Kinase

  Mark Windheim;Margaret Stafford;Mark Peggie;Philip Cohen

  163
  Citations