J. Simon C. Arthur

Overview

Best Publications

• The selectivity of protein kinase inhibitors: a further update.

  Jenny Bain;Lorna Plater;Matt Elliott;Natalia Shpiro

  2992
  Citations

• Mitogen-activated protein kinases in innate immunity

  J. Simon C. Arthur;Steven C. Ley

  1787
  Citations

• MSK2 and MSK1 mediate the mitogen‐ and stress‐induced phosphorylation of histone H3 and HMG‐14

  Ana Soloaga;Stuart Thomson;Giselle R. Wiggin;Navita Rampersaud

  605
  Citations

• The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.

  Michayla R. Williams;J.Simon C. Arthur;Anudharan Balendran;Jeroen van der Kaay

  591
  Citations

• MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.

  Giselle R. Wiggin;Ana Soloaga;Julia M. Foster;Victoria Murray-Tait

  537
  Citations

• Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

  Christoph H. Emmerich;Alban Ordureau;Sam Strickson;J. Simon C. Arthur

  456
  Citations

• Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

  J. Simon C. Arthur;John S. Elce;Carol Hegadorn;Karen Williams

  429
  Citations

• Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth

  Gopal P. Sapkota;Agnieszka Kieloch;Jose M. Lizcano;Sonia Lain

  386
  Citations

• The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

  Olga Ananieva;Joanne Darragh;Claus Johansen;Julia M Carr

  378
  Citations

• Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators

  Jin Mo Park;Florian R. Greten;Athena Wong;Randal J. Westrick

  378
  Citations

• Posttranslational Regulation of Tristetraprolin Subcellular Localization and Protein Stability by p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Pathways

  M. Brook;C. R. Tchen;T. Santalucia;J. McIlrath

  352
  Citations

• Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts

  Nathalie Dourdin;Amit K. Bhatt;Previn Dutt;Peter A. Greer

  327
  Citations

• The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression.

  Chun Kim;Yasuyo Sano;Kristina Todorova;Bradley A Carlson

  323
  Citations

• Generation and Characterization of p38β (MAPK11) Gene-Targeted Mice

  Victoria A. Beardmore;Heather J. Hinton;Christina Eftychi;Maria Apostolaki

  310
  Citations

• Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

  Zinan Zhou;Alan T. Tang;Weng Yew Wong;Sharika Bamezai

  290
  Citations

• p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP

  Guadalupe Sabio;Guadalupe Sabio;James Simon Campbell Arthur;Yvonne Kuma;Mark Peggie

  288
  Citations

• Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

  Kristopher Clark;Kirsty F. MacKenzie;Kasparas Petkevicius;Yosua Kristariyanto

  280
  Citations

• Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins

  J. Simon C. Arthur;Amy L. Fong;Jami M. Dwyer;Monika Davare

  274
  Citations

• MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

  J. Simson C. Arthur;Philip Cohen

  274
  Citations

• PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A–SIK–CRTC3 Pathway

  Kirsty F. MacKenzie;Kristopher Clark;Shaista Naqvi;Victoria A. McGuire

  268
  Citations