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Johannes M. H. M. Reul

Johannes M. H. M. Reul

D-Index & Metrics

Medicine

D-Index
87
Citations
23974
World Ranking
13769
National Ranking
1279

Overview

Johannes M. H. M. Reul is affiliated with the University of Bristol in the United Kingdom. Their research spans several core fields, primarily focused on biochemistry, genetics and molecular biology, neuroscience, and medicine. This interdisciplinary approach reflects in a body of work that integrates molecular biology and behavioral neuroscience with endocrinology, diabetes, and metabolism.

Their recent publication record includes several papers, with a focus on stress response mechanisms and hormonal regulation. Notable publications include:

  • "The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice" (2021) in Molecular Psychiatry
  • "Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors" (2021) in Nature Communications
  • "Genomic regulation of Krüppel-like-factor family members by corticosteroid receptors in the rat brain" (2023) in Neurobiology of Stress
  • "Insights into isoform-specific mineralocorticoid receptor action in the hippocampus" (2023) in Journal of Endocrinology
  • "P.866Epigenetic control of the glucocorticoid target gene Fkbp5 after stress in the hippocampus" (2020) in European Neuropsychopharmacology

The research topics frequently addressed include stress responses and cortisol, hormonal regulation and hypertension, estrogen and related hormone effects, circadian rhythm and melatonin, heat shock proteins research, microRNA in disease regulation, and birth, development, and health.

Common themes in their work also cover subfields such as molecular biology, behavioral neuroscience, endocrinology, diabetes and metabolism, genetics, and the endocrine and autonomic systems.

Johannes M. H. M. Reul collaborates regularly with several researchers. Frequent coauthors include:

  • Karen R. Mifsud
  • Emily M. Price
  • Hannah M. Goss
  • Clare Kennedy
  • Silvia Salatino

The scientist's work is published in a variety of journals, reflecting the interdisciplinary nature of their research:

  • Molecular Psychiatry
  • Nature Communications
  • Neurobiology of Stress
  • Journal of Endocrinology
  • European Neuropsychopharmacology

This combination of affiliations, publication venues, and research topics suggests a focus on understanding molecular mechanisms underlying stress and hormonal regulation, particularly through corticosteroid receptor action and related gene expression in brain regions such as the hippocampus and hypothalamus.

Best Publications

  • Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

    J. M. H. M. Reul;E. R. De Kloet

  • Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

    Peter Timpl;Rainer Spanagel;Inge Sillaber;Adelheid Kresse

  • Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems

    E.R. De Kloet;J.M.H.M. Reul

  • Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression.

    Johannes M H M Reul;Florian Holsboer

  • Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?

    N. Barden;N. Barden;J.M.H.M. Reul;F. Holsboer

  • Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

    Marianne B Müller;Stephan Zimmermann;Inge Sillaber;Thomas P Hagemeyer

  • Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis.

    Susanne K. Droste;Angela Gesing;Sabine Ulbricht;Marianne B. Müller

  • Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications.

    J. M. H. M. Reul;F. R. van den Bosch;E. R. de Kloet

  • Chronic Treatment of Rats with the Antidepressant Amitriptyline Attenuates the Activity of the Hypothalamic-Pituitary-Adrenocortical System

    J. M. H. M. Reul;I. Stec;M. Söder;F. Holsboer

  • Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis.

    J.M.H.M. Reul;E.R. De Kloet

  • Progesterone receptor-mediated effects of neuroactive steroids

    R. Rupprecht;J. M. H. M. Reul;T. Trapp;B. van Steensel

  • Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands

    R. Rupprecht;J. M. H. M. Reul;B. Van Steensel;D. Spengler

  • Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS

    Thorsten Trapp;Rainer Rupprecht;Maija Castrén;Johannes M.H.M. Reul

  • Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study

    A. C. E. Linthorst;C. Flachskamm;P. Muller-Preuss;F. Holsboer

  • Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress.

    Susanne K. Droste;Lotte de Groote;Helen C. Atkinson;Stafford L. Lightman

  • Induction of cytokine receptors by glucocorticoids: functional and pathological significance.

    G.J. Wiegers;J.M.H.M. Reul

  • Differential Response of Type I and Type II Corticosteroid Receptors to Changes in Plasma Steroid Level and Circadian Rhythmicity

    J M H M Reul;F R van den Bosch;E R de Kloet

  • The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.

    Johannes M.H.M Reul;Angela Gesing;Susanne Droste;Ingemar S.M Stec

  • The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-d-aspartate/extracellular signal-regulated kinase/mitogen- and stress-activated kinase signalling pathway

    Yalini Chandramohan;Susanne K. Droste;J. Simon C. Arthur;Johannes M. H. M. Reul

  • Type I and type II corticosteroid receptor gene expression in the rat: effect of adrenalectomy and dexamethasone administration.

    J. M. H. M. Reul;P. T. Pearce;J. W. Funder;Z. S. Krozowski

Frequent Co-Authors

Florian Holsboer
Florian Holsboer Max Planck Institute of Psychiatry
Andrew Collins
Andrew Collins University of Oslo
Stafford L. Lightman
Stafford L. Lightman University of Bristol
David J. Nutt
David J. Nutt Imperial College London
Rainer Landgraf
Rainer Landgraf Max Planck Society
Rainer Rupprecht
Rainer Rupprecht University of Regensburg
Marianne B. Müller
Marianne B. Müller Johannes Gutenberg University of Mainz
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Jan M. Deussing
Jan M. Deussing Max Planck Society
Jonathan Mill
Jonathan Mill University of Exeter

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