World's Best Scientists 2026 revealed!

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Medicine

D-Index
90
Citations
26671
World Ranking
12305
National Ranking
665

Overview

Rainer Rupprecht is affiliated with the University of Regensburg in Germany and has contributed extensively to the fields of neuroscience and medicine. Their research intersects multiple subfields including neurology, molecular biology, radiology, nuclear medicine and imaging, physiology, and cognitive neuroscience.

The scientist's work explores a variety of topics such as tryptophan and brain disorders, neuroinflammation and neurodegeneration mechanisms, Alzheimer's disease research and treatments, glioma diagnosis and treatment, neuroscience and neuropharmacology research, stress responses and cortisol, and functional brain connectivity studies.

Frequent venues for publication include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • European Archives of Psychiatry and Clinical Neuroscience
  • Molecular Psychiatry
  • European Journal of Nuclear Medicine and Molecular Imaging
  • Preprints.org

Frequent co-authors with whom Rupprecht has collaborated include:

  • Christian H. Wetzel
  • Matthias Brendel
  • Nathalie L. Albert
  • Peter Bartenstein
  • Caroline Nothdurfter

Among recent publications are:

  • "Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)" (2022, Nature Neuroscience)
  • "Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts" (2020, Cells)
  • "Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression" (2022, JAMA Network Open)
  • "Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?" (2022, Molecular Psychiatry)
  • "In Vivo Assessment of Neuroinflammation in 4-Repeat Tauopathies" (2020, Movement Disorders)

Their investigations often focus on molecular and cellular mechanisms underlying neuropsychiatric disorders, emphasizing mitochondrial function and neuroinflammation. Rupprecht's research examines both diagnostic markers and potential therapeutic targets, contributing to an enhanced understanding of brain disorders on biochemical and physiological levels.

The interdisciplinary approach is evident in publications spanning both clinical and basic sciences, integrating imaging techniques and molecular biology with cognitive and physiological assessments.

Best Publications

  • Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

    Elisabeth B Binder;Daria Salyakina;Peter Lichtner;Gabriele M Wochnik

  • Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

    Rainer Rupprecht;Vassilios Papadopoulos;Gerhard Rammes;Thomas C. Baghai

  • Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

    Rainer Rupprecht;Florian Holsboer

  • World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

    Borwin Bandelow;Josef Zohar;Eric Hollander;Siegfried Kasper

  • Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties.

    R. Rupprecht

  • Effects of antidepressant treatment on neuroactive steroids in major depression.

    E Romeo;A Ströhle;G Spalletta;F di Michele

  • SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression

    Zill P;Baghai Tc;Zwanzger P;Schüle C

  • Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.

    Thomas Frodl;Cornelius Schüle;Gisela Schmitt;Christine Born

  • Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

    Rainer Rupprecht;Rainer Rupprecht;Gerhard Rammes;Gerhard Rammes;Daniela Eser;Thomas C. Baghai

  • A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression

    Marcus Ising;Susanne Lucae;Elisabeth B. Binder;Thomas Bettecken

  • Progesterone receptor-mediated effects of neuroactive steroids

    R. Rupprecht;J. M. H. M. Reul;T. Trapp;B. van Steensel

  • Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands

    R. Rupprecht;J. M. H. M. Reul;B. Van Steensel;D. Spengler

  • Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS

    Thorsten Trapp;Rainer Rupprecht;Maija Castrén;Johannes M.H.M. Reul

  • The role of allopregnanolone in depression and anxiety

    Cornelius Schüle;Caroline Nothdurfter;Rainer Rupprecht

  • The N-methyl-d-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT3 receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

    G Rammes;R Rupprecht;U Ferrari;W Zieglgänsberger

  • Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment.

    Peter Zill;Thomas C. Baghai;Peter Zwanzger;Cornelius Schüle

  • Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators

    M. Lancel;J. Faulhaber;F. Holsboer;R. Rupprecht

  • Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology

    R Rupprecht;F di Michele;B Hermann;A Ströhle

  • The neuropsychopharmacological potential of neuroactive steroids

    Rainer Rupprecht

  • Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

    Marcus Karlstetter;Caroline Nothdurfter;Alexander Aslanidis;Katharina Moeller

Frequent Co-Authors

Peter Zwanzger
Peter Zwanzger Ludwig-Maximilians-Universität München
Florian Holsboer
Florian Holsboer Max Planck Institute of Psychiatry
Frank Padberg
Frank Padberg Ludwig-Maximilians-Universität München
Hans-Jürgen Möller
Hans-Jürgen Möller Ludwig-Maximilians-Universität München
H.-J. Möller
H.-J. Möller Ludwig-Maximilians-Universität München
Gerhard Rammes
Gerhard Rammes Technical University of Munich
Andreas Ströhle
Andreas Ströhle Charité - University Medicine Berlin
Markus J. Schwarz
Markus J. Schwarz Ludwig-Maximilians-Universität München
Manfred Uhr
Manfred Uhr Max Planck Society
Walter Zieglgänsberger
Walter Zieglgänsberger Max Planck Society

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