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Roberto C. Melcangi

Roberto C. Melcangi

D-Index & Metrics

Medicine

D-Index
73
Citations
14341
World Ranking
19733
National Ranking
794

Overview

Roberto C. Melcangi is affiliated with the University of Milan in Italy. Their research spans multiple fields including Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology, reflecting a broad focus on biological and medical sciences.

Their work covers specialized subfields such as Endocrinology, Diabetes and Metabolism, Molecular Biology, Behavioral Neuroscience, Genetics, and Physiology. This variety highlights the interdisciplinary nature of their research activities.

Main research topics addressed by Melcangi include:

  • Stress Responses and Cortisol
  • Gut microbiota and health
  • Hormonal and reproductive studies
  • Estrogen and related hormone effects
  • Tryptophan and brain disorders
  • Sexual function and dysfunction studies
  • Hormonal Regulation and Hypertension

Among the recent publications, significant contributions include:

  • Allopregnanolone: An overview on its synthesis and effects (2021, Journal of Neuroendocrinology)
  • Alterations of gut microbiota composition in post-finasteride patients: a pilot study (2020, Journal of Endocrinological Investigation)
  • Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites (2020, Frontiers in Neuroendocrinology)
  • Steroidogenic machinery in the adult rat colon (2020, The Journal of Steroid Biochemistry and Molecular Biology)
  • Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target (2021, Journal of Medicinal Chemistry)

Frequent co-authors in Melcangi's work are:

  • Silvia Giatti
  • Silvia Diviccaro
  • Lucia Cioffi
  • Donatella Caruso
  • Eva Falvo

The primary venues for publication include:

  • Journal of Neuroendocrinology
  • Biomolecules
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Frontiers in Neuroendocrinology
  • International Journal of Molecular Sciences

Best Publications

  • Steroid hormones and neurosteroids in normal and pathological aging of the nervous system

    Martin Schumacher;Sebastien Weill-Engerer;Philippe Liere;Francoise Robert

  • The 5 alpha-reductase in the brain: molecular aspects and relation to brain function.

    F Celotti;R C Melcangi;L Martini

  • Steroids and glial cell function.

    Luis M. Garcia-Segura;Roberto C. Melcangi

  • Neuroactive steroids: State of the art and new perspectives

    R. C. Melcangi;Luis M. García-Segura;A. G. Mensah-Nyagan

  • Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones.

    Daniel Garcia-Ovejero;Iñigo Azcoitia;Lydia L. DonCarlos;Roberto C. Melcangi

  • Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: A multimodal analysis

    E. Leonelli;R. Bianchi;G. Cavaletti;D. Caruso

  • Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats.

    Iñigo Azcoitia;Emanuela Leonelli;Valerio Magnaghi;Sergio Veiga

  • High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes.

    Andrea Volterra;Davide Trotti;Paola Cassutti;Cinzia Tromba

  • Differential localization of the 5 alpha-reductase and the 3 alpha-hydroxysteroid dehydrogenase in neuronal and glial cultures.

    R C Melcangi;F Celotti;P Castano;L Martini

  • Aromatase: a neuroprotective enzyme.

    Luis M Garcia-Segura;Sergio Veiga;Sergio Veiga;Amanda Sierra;Roberto C Melcangi

  • Estrogen receptor is expressed in different types of glial cells in culture.

    Sabrina Santagati;Roberto C. Melcangi;Fabio Celotti;Luciano Martini

  • Neurosteroidogenesis today: Novel targets for neuroactive steroid synthesis and action and their relevance for translational research.

    P. Porcu;A. M. Barron;C. A. Frye;C. A. Frye;A. A. Walf;A. A. Walf;A. A. Walf

  • Neuroactive steroids: focus on human brain

    R. C. Melcangi;G. Panzica;Luis M. García-Segura

  • Progesterone derivatives are able to influence peripheral myelin protein 22 and P0 gene expression: possible mechanisms of action.

    Roberto Cosimo Melcangi;V. Magnaghi;I. Cavarretta;I. Zucchi

  • The 5α-reductase in the central nervous system: expression and modes of control

    Roberto C Melcangi;Angelo Poletti;Ilaria Cavarretta;Fabio Celotti

  • Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease

    Anna M. Barron;Luis M. Garcia-Segura;Donatella Caruso;Anusha Jayaraman

  • Neuroactive steroids and peripheral myelin proteins.

    Valerio Magnaghi;Ilaria Cavarretta;Mariarita Galbiati;Luciano Martini

  • Comparison of plasma and cerebrospinal fluid levels of neuroactive steroids with their brain, spinal cord and peripheral nerve levels in male and female rats

    Donatella Caruso;Marzia Pesaresi;Federico Abbiati;Donato Calabrese

  • Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives.

    R.C Melcangi;V Magnaghi;I Cavarretta;L Martini

  • Neuroactive steroids: A therapeutic approach to maintain peripheral nerve integrity during neurodegenerative events.

    Emanuela Leonelli;Marinella Ballabio;Antonio Consoli;Ilaria Roglio

Frequent Co-Authors

Luis M. Garcia-Segura
Luis M. Garcia-Segura Spanish National Research Council
Donatella Caruso
Donatella Caruso University of Milan
Valerio Magnaghi
Valerio Magnaghi University of Milan
Guido Cavaletti
Guido Cavaletti University of Milano-Bicocca
Giancarlo Panzica
Giancarlo Panzica University of Turin
Nico Mitro
Nico Mitro University of Milan
Angelo Poletti
Angelo Poletti University of Milan
Giuseppe Lauria
Giuseppe Lauria University of Milan
Marco A. Riva
Marco A. Riva University of Milan
Ayikoe Guy Mensah-Nyagan
Ayikoe Guy Mensah-Nyagan University of Strasbourg

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