World's Best Scientists 2026 revealed!
Ayikoe Guy Mensah-Nyagan

Ayikoe Guy Mensah-Nyagan

D-Index & Metrics

Neuroscience

D-Index
44
Citations
5556
World Ranking
7260
National Ranking
326

Overview

Ayikoe Guy Mensah-Nyagan is affiliated with the University of Strasbourg in France. Their research spans multiple disciplines, primarily focusing on medicine, neuroscience, and biochemistry, genetics, and molecular biology. Within these domains, their work covers various subfields, including physiology, molecular biology, neurology, developmental neuroscience, and pathology and forensic medicine.

The scientist's main topics of research address several significant areas: Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, neurogenesis and neuroplasticity mechanisms, multiple sclerosis research studies, tryptophan and brain disorders, pain mechanisms and treatments, and cytokine signaling pathways and interactions.

Several recent papers showcase the diversity of their research focus. These include the following:

  • "Tryptophan metabolites modify brain Aβ peptide degradation: A role in Alzheimer's disease?" (2020), published in Progress in Neurobiology
  • "Myelin in Alzheimer's disease: culprit or bystander?" (2023), published in Acta Neuropathologica Communications
  • "Microglial Cell Morphology and Phagocytic Activity Are Critically Regulated by the Neurosteroid Allopregnanolone: A Possible Role in Neuroprotection" (2021), published in Cells
  • "A Role for Xanthurenic Acid in the Control of Brain Dopaminergic Activity" (2021), published in International Journal of Molecular Sciences
  • "The TOTEM RRMS (Testosterone Treatment on neuroprotection and Myelin Repair in Relapsing Remitting Multiple Sclerosis) trial: study protocol for a randomized, double-blind, placebo-controlled trial" (2020), published in Trials

The scientist frequently collaborates with a number of coauthors. The most frequent coauthors include:

  • Christine Patte-Mensah
  • Christian Klein
  • Laurence Meyer
  • de Sèze
  • Michel Maître

Their work often appears in several core publication venues. Most frequent among these are:

  • International Journal of Molecular Sciences
  • Neurotoxicity Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica Communications
  • Progress in Neurobiology

Best Publications

  • Neurosteroids: Expression of Steroidogenic Enzymes and Regulation of Steroid Biosynthesis in the Central Nervous System

    Ayikoe G. Mensah-Nyagan;Jean-Luc Do-Rego;Delphine Beaujean;Van Luu-The

  • Neuroactive steroids: State of the art and new perspectives

    R. C. Melcangi;Luis M. García-Segura;A. G. Mensah-Nyagan

  • Evidence for a key role of steroids in the modulation of pain

    Ayikoe G. Mensah-Nyagan;Laurence Meyer;Véronique Schaeffer;Cherkaouia Kibaly

  • Immunocytochemical localization and biological activity of 3 beta- hydroxysteroid dehydrogenase in the central nervous system of the frog

    AG Mensah-Nyagan;M Feuilloley;E Dupont;JL Do-Rego

  • Inflammatory pain upregulates spinal inhibition via endogenous neurosteroid production

    Pierrick Poisbeau;Christine Patte-Mensah;Anne Florence Keller;Michel Barrot

  • Improvement of neuronal bioenergetics by neurosteroids: Implications for age-related neurodegenerative disorders

    Amandine Grimm;Karen Schmitt;Undine E. Lang;Ayikoe Guy Mensah-Nyagan

  • Cellular distribution and bioactivity of the key steroidogenic enzyme, cytochrome P450side chain cleavage, in sensory neural pathways.

    Christine Patte-Mensah;Vincent Kappes;Marie José Freund-Mercier;Kazuyoshi Tsutsui

  • Alzheimer, mitochondria and gender

    Amandine Grimm;Ayikoe Guy Mensah-Nyagan;Anne Eckert

  • The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction.

    Christian Klein;Christine Patte-Mensah;Omar Taleb;Jean-Jacques Bourguignon

  • Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein

    Amandine Grimm;Amandine Grimm;Emily E. Biliouris;Undine E. Lang;Jürgen Götz

  • Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: Multi-parametric assessment and direct evidence

    Laurence Meyer;Christine Patte-Mensah;Omar Taleb;Ayikoe Guy Mensah-Nyagan

  • HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer’s disease-related tau pathology

    Julia Elisa Sepulveda-Diaz;Julia Elisa Sepulveda-Diaz;Seyedeh Maryam Alavi Naini;Seyedeh Maryam Alavi Naini;Minh Bao Huynh;Mohand Ouidir Ouidja;Mohand Ouidir Ouidja

  • Neurogenic pain and steroid synthesis in the spinal cord.

    Christine Patte-Mensah;Cherkaouia Kibaly;Domitille Boudard;Véronique Schaeffer

  • Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord

    Cherkaouia Kibaly;Laurence Meyer;Christine Patte-Mensah;Ayikoe G. Mensah-Nyagan

  • In Vivo and In Vitro Evidence for the Biosynthesis of Testosterone in the Telencephalon of the Female Frog

    Ayikoe G. Mensah-Nyagan;Jean-Luc Do-Rego;Marc Feuilloley;Albert Marcual

  • Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord.

    Christine Patte-Mensah;Trevor M. Penning;Ayikoe G. Mensah-Nyagan

  • The biological activity of 3α-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury

    Laurence Meyer;Christine Venard;Véronique Schaeffer;Christine Patte-Mensah

  • Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons.

    Véronique Schaeffer;Laurence Meyer;Christine Patte-mensah;Anne Eckert

  • Endogenous steroid production in the spinal cord and potential involvement in neuropathic pain modulation.

    A.G. Mensah-Nyagan;C. Kibaly;V. Schaeffer;C. Venard

  • Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: A potential component of nociception

    Christine Patte-Mensah;Cherkaouia Kibaly;Ayikoe G. Mensah-Nyagan

Frequent Co-Authors

Anne Eckert
Anne Eckert University of Basel
Marc G. J. Feuilloley
Marc G. J. Feuilloley University of Rouen
Luis M. Garcia-Segura
Luis M. Garcia-Segura Spanish National Research Council
Michel Barrot
Michel Barrot Centre national de la recherche scientifique, CNRS
Jean-Christophe Cassel
Jean-Christophe Cassel University of Strasbourg
Anne Giersch
Anne Giersch University of Strasbourg
Giancarlo Panzica
Giancarlo Panzica University of Turin
Cheryl A. Frye
Cheryl A. Frye University at Albany, State University of New York
Robert Fredriksson
Robert Fredriksson Uppsala University
Dan Larhammar
Dan Larhammar Uppsala University

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