World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
23613
World Ranking
4515
National Ranking
2195

Overview

Jian Yu is affiliated with the University of Pittsburgh in the United States and has an extensive research profile primarily focused on medicine, biochemistry, genetics, and molecular biology. Their work spans molecular biology, oncology, immunology, cancer research, and pulmonary and respiratory medicine.

The scientist's research topics emphasize cancer-related molecular mechanisms, cell death mechanisms and regulation, genetic factors in colorectal cancer, cancer immunotherapy and biomarkers, microRNA in disease regulation, nanoplatforms for cancer theranostics, and cancer-related molecular pathways.

Recent notable publications include:

  • "Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside" (2020), Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • "HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer" (2020), Journal of Experimental & Clinical Cancer Research
  • "Immunogenic cell death in colon cancer prevention and therapy" (2020), Molecular Carcinogenesis
  • "Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles inhibits triple-negative breast cancer progression and metastasis" (2021), Biomaterials
  • "Mcl-1 inhibition overcomes intrinsic and acquired Regorafenib resistance in Colorectal Cancer" (2020), Theranostics

Jian Yu frequently collaborates with Lin Zhang, Brian J. Leibowitz, Yourong Duan, Jingshan Tong, and Kaylee Ermine.

The scientist's publications are commonly found in the following journals and venues:

  • Oncogene
  • Cancer Research
  • International Journal of Radiation Oncology*Biology*Physics
  • Journal of Experimental & Clinical Cancer Research
  • Advanced Science

Best Publications

  • Mutations of mitotic checkpoint genes in human cancers

    Daniel P. Cahill;Christoph Lengauer;Jian Yu;Gregory J. Riggins

  • PUMA induces the rapid apoptosis of colorectal cancer cells.

    Jian Yu;Lin Zhang;Paul M. Hwang;Kenneth W. Kinzler

  • Role of BAX in the apoptotic response to anticancer agents.

    Lin Zhang;Jian Yu;Ben Ho Park;Kenneth W. Kinzler

  • Analysis of human transcriptomes

    Victor E Velculescu;Stephen L Madden;Lin Zhang;Alex E Lash

  • PUMA mediates the apoptotic response to p53 in colorectal cancer cells

    Jian Yu;Zhenghe Wang;Kenneth W. Kinzler;Bert Vogelstein

  • Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

    Sean M Baker;C.Eric Bronner;Lin Zhang;Annemieke W Plug

  • PUMA, a potent killer with or without p53

    J Yu;L Zhang

  • Identification and classification of p53-regulated genes

    Jian Yu;Lin Zhang;Paul M. Hwang;Carlo Rago

  • The transcriptional targets of p53 in apoptosis control.

    Jian Yu;Lin Zhang

  • Cell-cycle arrest versus cell death in cancer therapy

    Todd Waldman;Yonggang Zhang;Larry Dillehay;Jian Yu

  • Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells

    Paul M. Hwang;Fred Bunz;Jian Yu;Carlo Rago

  • Influence of induced reactive oxygen species in p53-mediated cell fate decisions.

    Salvador Macip;Makoto Igarashi;Petra Berggren;Jian Yu

  • microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells

    Peng Wang;Fangdong Zou;Xiaodong Zhang;Hua Li

  • Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species.

    Steven P. Donald;Xiao Ya Sun;Chien An A. Hu;Jian Yu

  • No PUMA, no death: Implications for p53-dependent apoptosis

    Jian Yu;Lin Zhang

  • Mitochondrial signaling in cell death via the Bcl-2 family.

    Brian Leibowitz;Jian Yu

  • Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics.

    Paraskevi Giannakakou;Michel Nakano;Kyriacos C. Nicolaou;Aurora O'Brate

  • PUMA Regulates Intestinal Progenitor Cell Radiosensitivity and Gastrointestinal Syndrome

    Wei Qiu;Eleanor B. Carson-Walter;Hongtao Liu;Michael Epperly

  • Immunogenic effects of chemotherapy-induced tumor cell death.

    Yi-Jun Wang;Rochelle Fletcher;Jian Yu;Lin Zhang

  • Regulation of PUMA- α by p53 in cisplatin-induced renal cell apoptosis

    M Jiang;Q Wei;J Wang;Q Du

Frequent Co-Authors

Bert Vogelstein
Bert Vogelstein Johns Hopkins University
Kenneth W. Kinzler
Kenneth W. Kinzler Johns Hopkins University
Robert E. Schoen
Robert E. Schoen University of Pittsburgh
Joel S. Greenberger
Joel S. Greenberger University of Pittsburgh
Michael W. Epperly
Michael W. Epperly University of Pittsburgh
Paul M. Hwang
Paul M. Hwang National Institutes of Health
Peter Wipf
Peter Wipf University of Pittsburgh
Linheng Li
Linheng Li Stowers Institute for Medical Research
Gerard P. Zambetti
Gerard P. Zambetti St. Jude Children's Research Hospital
Xinwei Wang
Xinwei Wang Peking University

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