World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
68
Citations
26917
World Ranking
1495
National Ranking
758

Research.com Recognitions

  • 2018 - Director's Awards, William Jewel Team Science, University of Kansas Cancer Center
  • 2017 - Director's Awards, Basic Science, University of Kansas Cancer Center
  • 2013 - Fellow of the American Gastroenterological Association (AGA)
  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2004 - Hudson Prize, M.R. and Evelyn Hudson Foundation for Excellence in basic biomedical research
  • 2003 - Award for Excellence in Life Science for Basic Research, Missouri Biotechnology Association

Overview

Linheng Li is affiliated with the Stowers Institute for Medical Research in the United States. Their research work spans several interconnected fields, primarily focusing on medicine, biochemistry, genetics, and molecular biology. They have made contributions across various subfields, including molecular biology, oncology, immunology, hematology, and genetics.

The main topics in Linheng Li's body of research include:

  • Cancer Cells and Metastasis
  • Hematopoietic Stem Cell Transplantation
  • Single-cell and spatial transcriptomics
  • CO2 Reduction Techniques and Catalysts
  • Mesenchymal stem cell research
  • Pregnancy and preeclampsia studies
  • Carbon dioxide utilization in catalysis

They have published extensively, with notable recent papers such as:

  • "Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells," 2020, Nature Cell Biology
  • "Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche," 2021, Cell Reports
  • "Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis," 2022, Journal of Hepatology
  • "Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury," 2024, Cell
  • "Intestinal epithelial regeneration: active versus reserve stem cells and plasticity mechanisms," 2020, American Journal of Physiology-Gastrointestinal and Liver Physiology

Frequent publication venues for Linheng Li include:

  • Blood
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • bioRxiv (Cold Spring Harbor Laboratory)

Regarding collaboration, Linheng Li has worked repeatedly with several co-authors, including:

  • Xinjian Mao
  • Xi He
  • Jay R. Unruh
  • Allison Scott
  • Anoja Perera

Best Publications

  • Identification of the haematopoietic stem cell niche and control of the niche size

    Jiwang Zhang;Chao Niu;Ling Ye;Haiyang Huang

  • STEM CELL NICHE: Structure and Function

    Linheng Li;Ting Xie

  • Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

    Linheng Li;Ian D. Krantz;Yu Deng;Yu Deng;Anna Genin

  • Coexistence of Quiescent and Active Adult Stem Cells in Mammals

    Linheng Li;Hans Clevers

  • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling

    Xi C. He;Jiwang Zhang;Wei Gang Tong;Ossama Tawfik

  • The stem cell niches in bone.

    Tong Yin;Linheng Li

  • PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

    Jiwang Zhang;Justin C. Grindley;Tong Yin;Sachintha Jayasinghe

  • Normal Stem Cells and Cancer Stem Cells: The Niche Matters

    Linheng Li;William B. Neaves

  • Detection of functional haematopoietic stem cell niche using real-time imaging

    Yucai Xie;Tong Yin;Winfried Wiegraebe;Xi C. He

  • Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

    Meng Zhao;John M Perry;Heather Marshall;Aparna Venkatraman

  • PTEN-deficient intestinal stem cells initiate intestinal polyposis.

    Xi C He;Tong Yin;Justin C Grindley;Qiang Tian

  • Hematopoietic Stem Cells Contribute to the Regeneration of Renal Tubules after Renal Ischemia-Reperfusion Injury in Mice

    Fangming Lin;Kimberly Cordes;Linheng Li;Leroy Hood

  • Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

    Koichi Akashi;Xi He;Xi He;Xi He;Jie Chen;Jie Chen;Jie Chen;Hiromi Iwasaki;Hiromi Iwasaki;Hiromi Iwasaki

  • Current view: intestinal stem cells and signaling.

    David H. Scoville;Toshiro Sato;Xi C. He;Linheng Li;Linheng Li

  • c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

    Lin-Heng Li;C. Nerlov;G. Prendergast;D. Macgregor

  • The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1

    Linheng Li;Laurie A Milner;Yu Deng;Yu Deng;Mineo Iwata

  • From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs

    A. V. Terskikh;M. C. Easterday;L. Li;L. Hood

  • Notch Activation Results in Phenotypic and Functional Changes Consistent With Endothelial-to-Mesenchymal Transformation

    Michela Noseda;Graeme McLean;Kyle Niessen;Linda Chang

  • Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways

    Porfirio Nava;Stefan Koch;Mike G. Laukoetter;Mike G. Laukoetter;Winston Y. Lee

  • Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity

    Kelley S. Yan;Kelley S. Yan;Olivier Gevaert;Grace X.Y. Zheng;Benedict Anchang

Frequent Co-Authors

Leroy Hood
Leroy Hood University of Washington
Jian Yu
Jian Yu University of Pittsburgh
Sheng Ding
Sheng Ding Tsinghua University
Barbara J. Trask
Barbara J. Trask Fred Hutchinson Cancer Research Center
Calvin J. Kuo
Calvin J. Kuo Stanford University
Nancy B. Spinner
Nancy B. Spinner Children's Hospital of Philadelphia
Ian D. Krantz
Ian D. Krantz Children's Hospital of Philadelphia
Charles A. Parkos
Charles A. Parkos University of Michigan–Ann Arbor
Irving L. Weissman
Irving L. Weissman Stanford University
Gen-Sheng Feng
Gen-Sheng Feng University of California, San Diego

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