World's Best Scientists 2026 revealed!
Jean-Pierre Levesque

Jean-Pierre Levesque

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
13295
World Ranking
13705
National Ranking
381

Overview

Jean-Pierre Levesque is affiliated with the University of Queensland in Australia and has focused primarily on research in the field of Medicine, contributing extensively to several subfields including Immunology, Rheumatology, Hematology, Molecular Biology, and Genetics. Their work covers various topics centered on hematopoietic and immune system functions, with particular interest in conditions related to bone, blood, and cancer.

The main topics addressed in their research include:

  • Heterotopic Ossification and Related Conditions
  • Hematopoietic Stem Cell Transplantation
  • Cervical and Thoracic Myelopathy
  • Immune cells in cancer
  • Immune Cell Function and Interaction
  • Erythrocyte Function and Pathophysiology
  • Acute Myeloid Leukemia Research

Levesque has published multiple papers in a variety of scientific venues. Frequent publication outlets include:

  • Experimental Hematology
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Bone and Mineral Research
  • Current Osteoporosis Reports

Some of the recent notable papers by Levesque include:

  • Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance, 2020, Nature Communications
  • Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues, 2021, Cell Reports
  • Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release, 2021, The Journal of Experimental Medicine
  • Acute Myeloid Leukemia Chemo-Resistance Is Mediated by E-selectin Receptor CD162 in Bone Marrow Niches, 2020, Frontiers in Cell and Developmental Biology
  • GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection, 2022, European Respiratory Journal

Levesque collaborates frequently with a group of coauthors, including:

  • Ingrid G. Winkler
  • Kylie A. Alexander
  • Kavita Bisht
  • Valérie Barbier
  • Susan Millard

Best Publications

  • Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.

    Jean-Pierre Lévesque;Jean Hendy;Yasushi Takamatsu;Paul J. Simmons

  • Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

    Ingrid G. Winkler;Natalie A. Sims;Allison R. Pettit;Valérie Barbier

  • Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor

    Jean Pierre Lévesque;Yasushi Takamatsu;Susan K. Nilsson;David N. Haylock

  • G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow

    Craig L. Semerad;Matthew J. Christopher;Fulu Liu;Brenton Short

  • Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

    Ingrid G Winkler;Valérie Barbier;Bianca Nowlan;Rebecca N Jacobsen

  • Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins.

    J P Lévesque;D I Leavesley;S Niutta;M Vadas

  • Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment.

    Jean Pierre Lévesque;Jean Hendy;Yasushi Takamatsu;Brenda Williams

  • Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.

    Jacques Hatzfeld;Ma-Lin Li;Eugene L. Brown;Hemchand Sookdeo

  • Characterization of hematopoietic progenitor mobilization in protease-deficient mice.

    Jean Pierre Levesque;Fulu Liu;Paul J. Simmons;Tomoko Betsuyaku

  • The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization

    Lévesque Jp;Helwani Fm;Winkler Ig

  • How I treat patients who mobilize hematopoietic stem cells poorly.

    L. Bik To;L. Bik To;Jean-Pierre Levesque;Kirsten E. Herbert

  • Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta.

    Gary Brooke;Hui Tong;Jean-Pierre Levesque;Kerry Atkinson

  • Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

    Ingrid G. Winkler;Valérie Barbier;Robert Wadley;Andrew C. W. Zannettino

  • Release from quiescence of CD34+ CD38- human umbilical cord blood cells reveals their potentiality to engraft adults.

    A A Cardoso;M L Li;P Batard;A Hatzfeld

  • Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells.

    Jean-Pierre Lévesque;Jean Hendy;Ingrid G Winkler;Yasushi Takamatsu

  • Osteoclast-Mediated Bone Resorption Is Stimulated During Short-Term Administration of Granulocyte Colony-Stimulating Factor But Is Not Responsible for Hematopoietic Progenitor Cell Mobilization

    Yasushi Takamatsu;Paul J. Simmons;Robert J. Moore;Howard A. Morris

  • Cytokine Regulation of Proliferation and Cell Adhesion Are Correlated Events in Human CD34+ Hemopoietic Progenitors

    JP Levesque;DN Haylock;PJ Simmons

  • Hematopoietic Progenitor Cell Mobilization Results in Hypoxia with Increased Hypoxia-Inducible Transcription Factor-1α and Vascular Endothelial Growth Factor A in Bone Marrow

    Jean‐Pierre Lévesque;Ingrid G. Winkler;Jean Hendy;Brenda Williams

  • Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation.

    I G Winkler;A R Pettit;L J Raggatt;R N Jacobsen

  • Mechanisms of hematopoietic stem cell mobilization: when innate immunity assails the cells that make blood and bone.

    Ingrid G. Winkler;Jean-Pierre Lévesque

Frequent Co-Authors

Dietmar W. Hutmacher
Dietmar W. Hutmacher Queensland University of Technology
Andrew C. Perkins
Andrew C. Perkins Monash University
Natalie A. Sims
Natalie A. Sims St Vincents Institute of Medical Research
David A. Hume
David A. Hume University of Queensland
John E.J. Rasko
John E.J. Rasko Centenary Institute of Cancer Medicine and Cell Biology
David N. Haylock
David N. Haylock Commonwealth Scientific and Industrial Research Organisation
Andrew C.W. Zannettino
Andrew C.W. Zannettino University of Adelaide
Steven C. Clark
Steven C. Clark Pfizer (Canada)
Susan K. Nilsson
Susan K. Nilsson Commonwealth Scientific and Industrial Research Organisation
Kelli P. A. MacDonald
Kelli P. A. MacDonald QIMR Berghofer Medical Research Institute

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry opens doors to a wide range of online degrees and healthcare careers in the USA. Many students use their foundational knowledge to branch out into specialized graduate certificates or advanced nursing fields. For example, current registered nurses interested in advancing their practice may consider the shortest post master's fnp program options for quick, flexible routes to becoming a Family Nurse Practitioner.

Those who are passionate about nutrition can look into online dietetics programs that offer affordable paths toward credentials in nutrition and dietetics. Additionally, registered nurses wanting to earn a bachelor's degree efficiently may benefit from online rn to bsn programs, which are designed to accommodate busy schedules and help you advance your clinical expertise.

If leadership is your goal, the fastest online master's in healthcare management programs can prepare you for roles in healthcare administration and management in less time than traditional degrees. These online pathways offer flexibility and tailored curricula, making them accessible for working professionals who want to expand their skill sets and career options.

Best Scientists Citing Jean-Pierre Levesque

Trending Scientists

Recently Published Articles