World's Best Scientists 2026 revealed!
P. Lynne Howell

P. Lynne Howell

D-Index & Metrics

Chemistry

D-Index
48
Citations
7793
World Ranking
15294
National Ranking
417

Biology and Biochemistry

D-Index
57
Citations
10634
World Ranking
13939
National Ranking
483

Overview

P. Lynne Howell is affiliated with the University of Toronto in Canada and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology. Their research spans over 100 publications primarily focusing on bacterial biofilms, quorum sensing, and molecular mechanisms underlying microbial interactions.

The main fields of study for this scientist include:

  • Biochemistry, Genetics and Molecular Biology

Key subfields of study comprise:

  • Molecular Biology
  • Genetics
  • Periodontics
  • Ecology
  • Infectious Diseases

Howell's research topics cover several areas, with emphasis on:

  • Bacterial biofilms and quorum sensing
  • Bacterial Genetics and Biotechnology
  • Oral microbiology and periodontitis research
  • Bacteriophages and microbial interactions
  • Antibiotic Resistance in Bacteria
  • Glycosylation and Glycoproteins Research
  • Antifungal resistance and susceptibility

Their documented co-authors include:

  • Gregory B. Whitfield
  • Donald C. Sheppard
  • François Le Mauff
  • Matthew R. Parsek
  • Deepa Raju

Howell has published frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • mBio
  • Communications Biology
  • Nature Communications

Selected recent papers include:

  • "A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa", 2021, Molecular Cell
  • "Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation", 2020, Nature Communications
  • "Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems", 2021, Advanced Drug Delivery Reviews
  • "The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine", 2022, Communications Biology
  • "Pseudomonas aeruginosa biofilm exopolysaccharides: assembly, function, and degradation", 2023, FEMS Microbiology Reviews

Best Publications

  • The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix

    Kelly M. Colvin;Yasuhiko Irie;Catherine S. Tart;Rodolfo Urbano

  • Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl

    Michael J. Franklin;David E. Nivens;Joel T. Weadge;P. Lynne Howell

  • Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix

    Laura K. Jennings;Kelly M. Storek;Hannah E. Ledvina;Charlène Coulon

  • Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange

    Laura R Hmelo;Bradley R Borlee;Henrik Almblad;Michelle E Love

  • The phage λ major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion system

    Lisa G. Pell;Voula Kanelis;Logan W. Donaldson;P. Lynne Howell

  • Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

    Perrin Baker;Preston J. Hill;Brendan D. Snarr;Brendan D. Snarr;Noor Alnabelseya

  • Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli

    Vipender Singh;Gary B. Evans;Dirk H. Lenz;Jennifer M. Mason

  • Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection.

    Dominique H. Limoli;Dominique H. Limoli;Gregory B. Whitfield;Tomoe Kitao;Tomoe Kitao;Melissa L. Ivey

  • Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa

    John C. Whitney;Kelly M. Colvin;Lindsey S. Marmont;Howard Robinson

  • The platform protein is essential for type IV pilus biogenesis.

    Herlinder K. Takhar;Kevin Kemp;Melissa Kim;P. Lynne Howell

  • Architecture of the type II secretion and type IV pilus machineries.

    Melissa Ayers;P Lynne Howell;Lori L Burrows

  • AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin

    Carrie-Lynn Keiski;Michael Harwich;Sumita Jain;Ana Mirela Neculai

  • A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa

    Megha Shah;Véronique L. Taylor;Diane Bona;Yvonne Tsao

  • Enzymatic modifications of exopolysaccharides enhance bacterial persistence

    Gregory B. Whitfield;Lindsey S. Marmont;P. Lynne Howell

  • The molecular mechanism of the type IVa pilus motors

    Matthew McCallum;Stephanie Tammam;Ahmad Khan;Lori L. Burrows

  • Functional role of conserved residues in the characteristic secretion NTPase motifs of the Pseudomonas aeruginosa type IV pilus motor proteins PilB, PilT and PilU.

    Poney Chiang;Liliana M. Sampaleanu;Melissa Ayers;Markian Pahuta

  • PilMNOPQ from the Pseudomonas aeruginosa Type IV Pilus System form a Transenvelope Protein Interaction Network that Interacts with PilA

    Stephanie Tammam;Liliana M. Sampaleanu;Jason Koo;Kumararaaj Manoharan

  • Biogenesis of Pseudomonas aeruginosa type IV pili and regulation of their function

    Tiffany L. Leighton;Ryan N. C. Buensuceso;P. Lynne Howell;Lori L. Burrows

  • PelA Deacetylase Activity Is Required for Pel Polysaccharide Synthesis in Pseudomonas aeruginosa

    Kelly M. Colvin;Noor Alnabelseya;Perrin Baker;John C. Whitney

  • Crystal structure of a class I α1,2‐mannosidase involved in N‐glycan processing and endoplasmic reticulum quality control

    François Vallée;Francesco Lipari;Patrick Yip;Barry Sleno

  • Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding

    Arash Zarrine-Afsar;Stefan Wallin;A. Mirela Neculai;Philipp Neudecker

  • PilF Is an Outer Membrane Lipoprotein Required for Multimerization and Localization of the Pseudomonas aeruginosa Type IV Pilus Secretin

    Jason Koo;Stephanie Tammam;Shao-Yang Ku;Liliana M. Sampaleanu

  • Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues.

    Vipender Singh;Jeffrey E. Lee;Sara Núñez;P. Lynne Howell

Frequent Co-Authors

Lori L. Burrows
Lori L. Burrows McMaster University
Donald C. Sheppard
Donald C. Sheppard McGill University
Howard Robinson
Howard Robinson Brookhaven National Laboratory
Matthew R. Parsek
Matthew R. Parsek University of Washington
Daniel J. Wozniak
Daniel J. Wozniak The Ohio State University
Alan R. Davidson
Alan R. Davidson University of Toronto
Joe J. Harrison
Joe J. Harrison University of Calgary
Jeroen D. C. Codée
Jeroen D. C. Codée Leiden University
Dennis E. Ohman
Dennis E. Ohman Virginia Commonwealth University Medical Center
Scott G. Filler
Scott G. Filler University of California, Los Angeles

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring career options after studying Biology or Biochemistry in the USA opens a wide range of possibilities, especially through online degree programs. Many students are now pursuing healthcare-related careers that build upon a biology background.

For those interested in nursing, an rn to bsn online program is a flexible way to advance in the nursing field. If you aspire to move into healthcare administration, an accelerated healthcare management degree online can quickly prepare you for leadership roles.

Mental health is a growing field; with the fastest pmhnp program, biology graduates can specialize as psychiatric mental health nurse practitioners. Additionally, for those passionate about diet and wellbeing, a fast track nutrition degree offers a streamlined path to become a nutritionist or dietitian.

Online pathways like these allow you to build on your science education and transition into high-demand, rewarding roles in healthcare and related fields.

Best Scientists Citing P. Lynne Howell

Trending Scientists

Recently Published Articles