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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
11091
World Ranking
11000
National Ranking
397

Overview

Silvia Spinelli is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research spans several areas within biochemistry, genetics, and molecular biology, with a focus on molecular biology, ecology, endocrinology, genetics, and cancer research. The scientific work also covers topics related to bacteriophages and microbial interactions, RNA and protein synthesis mechanisms, Vibrio bacteria research, genomics and phylogenetic studies, cancer genomics and diagnostics, Escherichia coli research studies, and bacterial genetics and biotechnology.

Spinelli has contributed to a range of publications in notable scientific journals. Key recent papers include:

  • "Conserved and Diverse Traits of Adhesion Devices from Siphoviridae Recognizing Proteinaceous or Saccharidic Receptors," 2020, published in Viruses
  • "Revisiting the host adhesion determinants of Streptococcus thermophilus siphophages," 2020, published in Microbial Biotechnology
  • "Anchoring the T6SS to the cell wall: Crystal structure of the peptidoglycan binding domain of the TagL accessory protein," 2021, published in PLoS ONE
  • "Structural Insights into Lactococcal Siphophage p2 Baseplate Activation Mechanism," 2020, published in Viruses
  • "Liquid Biopsy in Cancer: Focus on Lymphoproliferative Disorders," 2022, published in Cancers

Frequent collaborators include Christian Cambillau, Adeline Goulet, Deborah D'Aliberti, Rocco Piazza, and Jennifer Mahony.

Spinelli's publications are often found in journals such as Viruses, Microbial Biotechnology, PLoS ONE, Cancers, and Cells. This distribution reflects the multidisciplinary nature of their research work spanning molecular biology and medical fields.

Best Publications

  • Conformations of immunoglobulin hypervariable regions.

    Cyrus Chothia;Cyrus Chothia;Arthur M. Lesk;Anna Tramontano;Michael Levitt;Michael Levitt

  • Mammalian odorant binding proteins

    Mariella Tegoni;Paolo Pelosi;Florence Vincent;Silvia Spinelli

  • Biogenesis and structure of a type VI secretion membrane core complex

    Eric Durand;Van Son Nguyen;Abdelrahim Zoued;Laureen Logger

  • The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU.

    S Spinelli;Q Z Liu;P M Alzari;P H Hirel

  • Directed in vitro evolution and crystallographic analysis of a peptide-binding single chain antibody fragment (scFv) with low picomolar affinity

    Christian Zahnd;Silvia Spinelli;Béatrice Luginbühl;Patrick Amstutz

  • Domain swapping creates a third putative combining site in bovine odorant binding protein dimer.

    Mariella Tegoni;Roberto Ramoni;Enrico Bignetti;Silvia Spinelli

  • Crystal Structure of E.Coli Alcohol Dehydrogenase Yqhd: Evidence of a Covalently Modified Nadp Coenzyme

    Gerlind Sulzenbacher;Karine Alvarez;Robert H.H. van den Heuvel;Cees Versluis

  • A common protein fold and similar active site in two distinct families of beta-glycanases.

    Roberto Dominguez;Hélène Souchon;Silvia Spinelli;Zbigniew Dauter

  • Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.

    Aline Desmyter;Silvia Spinelli;Françoise Payan;Marc Lauwereys

  • Camelid Heavy-Chain Variable Domains Provide Efficient Combining Sites to Haptens†

    Silvia Spinelli;Leon G. J. Frenken;Pim Hermans;Theo Verrips

  • The crystal structure of a llama heavy chain variable domain.

    S Spinelli;L Frenken;D Bourgeois;L de Ron

  • Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response.

    P M Alzari;S Spinelli;R A Mariuzza;G Boulot

  • Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo.

    Edward Dolk;Marcel van der Vaart;David Lutje Hulsik;Gert Vriend

  • Structural basis of sialyltransferase activity in trypanosomal sialidases.

    Alejandro Buschiazzo;Gisele A. Tavares;Gisele A. Tavares;Oscar Campetella;Silvia Spinelli

  • Modular Structure of the Receptor Binding Proteins of Lactococcus lactis Phages THE RBP STRUCTURE OF THE TEMPERATE PHAGE TP901-1

    Silvia Spinelli;Valérie Campanacci;Stéphanie Blangy;Sylvain Moineau

  • Complexes of Porcine Odorant Binding Protein with Odorant Molecules Belonging to Different Chemical Classes

    Florence Vincent;Silvia Spinelli;Roberto Ramoni;Stefano Grolli

  • Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism

    David Veesler;Silvia Spinelli;Jennifer Mahony;Julie Lichière

  • Crystal structure of Apis mellifera OBP14, a C-minus odorant-binding protein, and its complexes with odorant molecules.

    Silvia Spinelli;Amandine Lagarde;Immacolata Iovinella;Pierre Legrand

  • THE CRYSTAL STRUCTURE OF A COCKROACH PHEROMONE-BINDING PROTEIN SUGGESTS A NEW LIGAND BINDING AND RELEASE MECHANISM

    Audrey Lartigue;Arnaud Gruez;Silvia Spinelli;Stéphane Rivière

  • Lactococcal Bacteriophage P2 Receptor-Binding Protein Structure Suggests a Common Ancestor Gene with Bacterial and Mammalian Viruses.

    Silvia Spinelli;Aline Desmyter;C Theo Verrips;Hans J W de Haard

Frequent Co-Authors

Christian Cambillau
Christian Cambillau Centre national de la recherche scientifique, CNRS
Mariella Tegoni
Mariella Tegoni Centre national de la recherche scientifique, CNRS
Eric Cascales
Eric Cascales Aix-Marseille University
Sylvain Moineau
Sylvain Moineau Université Laval
David Veesler
David Veesler University of Washington
Pedro M. Alzari
Pedro M. Alzari Institut Pasteur
Roberto J. Poljak
Roberto J. Poljak University of Maryland, College Park
Paolo Pelosi
Paolo Pelosi Austrian Institute of Technology
Andreas Plückthun
Andreas Plückthun University of Zurich
Didier Raoult
Didier Raoult Aix-Marseille University

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