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Andreas Plückthun

Andreas Plückthun

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Biology and Biochemistry
Switzerland
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
135
Citations
61604
World Ranking
353
National Ranking
10

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Switzerland Leader Award
  • 2025 - Research.com Biology and Biochemistry in Switzerland Leader Award
  • 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award
  • 2022 - Research.com Biology and Biochemistry in Switzerland Leader Award
  • 2003 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Biochemistry and Biophysics
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Andreas Plückthun is affiliated with the University of Zurich in Switzerland. Their research spans biochemistry, genetics, molecular biology, and medicine, with particular emphasis on molecular biology, oncology, radiology, nuclear medicine and imaging, genetics, and cell biology.

The main topics of their scientific work include:

  • Monoclonal and Polyclonal Antibodies Research
  • Receptor Mechanisms and Signaling
  • Virus-based gene therapy research
  • Viral Infectious Diseases and Gene Expression in Insects
  • CAR-T cell therapy research
  • RNA and protein synthesis mechanisms
  • Neuropeptides and Animal Physiology

Andreas Plückthun has contributed to numerous scientific publications. Recent papers include:

  • Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs, 2021, Nature Structural & Molecular Biology
  • Flavonol-mediated stabilization of PIN efflux complexes regulates polar auxin transport, 2020, The EMBO Journal
  • Animal-free alternatives and the antibody iceberg, 2020, Nature Biotechnology
  • Crystal structure of the human oxytocin receptor, 2020, Science Advances
  • Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins, 2020, Nature Communications

The scientist frequently publishes in several venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Science Advances
  • Nature Structural & Molecular Biology
  • mAbs

Significant collaborative relationships are evident through co-authorship with:

  • Birgit Dreier
  • Jonas V. Schaefer
  • Patrick C. Freitag
  • Dominik Brücher
  • Patrick Erñst

Awards received include membership in the German National Academy of Sciences Leopoldina, recognized in biochemistry and biophysics, awarded in 2003, as well as membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • In vitro selection and evolution of functional proteins by using ribosome display.

    Jozef Hanes;Andreas Plückthun

  • Assembly of a functional immunoglobulin Fv fragment in Escherichia coli.

    Arne Skerra;Andreas Plückthun

  • Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides.

    Achim Knappik;Liming Ge;Annemarie Honegger;Peter Pack

  • Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

    Awen Gallimore;Ann Glithero;Andrew Godkin;Alain C. Tissot

  • Engineering novel binding proteins from nonimmunoglobulin domains

    H Kaspar Binz;Patrick Amstutz;Andreas Plückthun

  • High-affinity binders selected from designed ankyrin repeat protein libraries.

    H Kaspar Binz;Patrick Amstutz;Andreas Kohl;Michael T Stumpp

  • In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei.

    Christiane Schaffitzel;Imre Berger;Jan Postberg;Jozef Hanes

  • Stability engineering of antibody single-chain Fv fragments.

    Arne Wörn;Andreas Plückthun

  • Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.

    H.Kaspar Binz;Michael T Stumpp;Patrik Forrer;Patrick Amstutz

  • Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system

    Anke Krebber;Susanne Bornhauser;Jörg Burmester;Annemarie Honegger

  • Reproducibility: Standardize antibodies used in research

    Andrew Bradbury;Andreas Plückthun

  • Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

    Andreas Plückthun

  • Antibodies from Escherichia coli

    A. Plückthun

  • Yet Another Numbering Scheme for Immunoglobulin Variable Domains: An Automatic Modeling and Analysis Tool

    Annemarie Honegger;Andreas Plückthun

  • Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display

    Jozef Hanes;Christiane Schaffitzel;Achim Knappik;Andreas Plückthun

  • New protein engineering approaches to multivalent and bispecific antibody fragments

    Andreas Plückthun;Peter Pack

  • Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering.

    Stefan Ewert;Annemarie Honegger;Andreas Plückthun

  • In-vitro protein evolution by ribosome display and mRNA display

    Dasa Lipovsek;Andreas Plückthun

  • Miniantibodies: use of amphipathic helices to produce functional, flexibly linked dimeric FV fragments with high avidity in Escherichia coli.

    P Pack;A Plückthun

  • Trinucleotide phosphoramidites: ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis

    B Virnekäs;L Ge;A Plückthun;K C Schneider

Frequent Co-Authors

Annemarie Honegger
Annemarie Honegger University of Zurich
Uwe Zangemeister-Wittke
Uwe Zangemeister-Wittke University of Bern
Markus G. Grütter
Markus G. Grütter University of Zurich
Edward A. Dennis
Edward A. Dennis University of California, San Diego
Andrew Bradbury
Andrew Bradbury Los Alamos National Laboratory
Daniel Scott
Daniel Scott University of Waterloo
Hans Binz
Hans Binz University of Zurich
Arne Skerra
Arne Skerra Technical University of Munich
Amedeo Caflisch
Amedeo Caflisch University of Zurich

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