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Annemarie Honegger

Annemarie Honegger

D-Index & Metrics

Molecular Biology

D-Index
57
Citations
15359
World Ranking
2135
National Ranking
36

Overview

Annemarie Honegger is affiliated with the University of Zurich in Switzerland and has contributed to diverse areas within medicine and biochemistry. Their research spans several key fields, including molecular biology, surgery, oncology, radiology, nuclear medicine and imaging, and cellular and molecular neuroscience.

Their recent publications reflect interests in molecular and cellular mechanisms, therapeutic antibodies, and infection treatments. Notable papers include:

  • Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism (2021, Science Advances)
  • Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action (2021, Nature Communications)
  • Antimicrobial Efficacy of Five Wound Irrigation Solutions in the Biofilm Microenvironment In Vitro and Ex Vivo (2025, Antibiotics)
  • Molecular features defining the efficiency of bioPROTACs (2025, Communications Biology)
  • Correction: Honegger et al. Antimicrobial Efficacy of Five Wound Irrigation Solutions in the Biofilm Microenvironment In Vitro and Ex Vivo. Antibiotics 2025, 14, 25 (2025, Antibiotics)

Frequent co-authors collaborating with Honegger include:

  • Andreas Plückthun
  • Patrick Erñst
  • Peer R. E. Mittl
  • Tiziano A. Schweizer
  • Yvonne Achermann

Publication venues where Honegger's work has appeared more than once include:

  • Antibiotics
  • Nature Communications
  • Science Advances
  • Communications Biology

The main fields of study related to their work are medicine and biochemistry, genetics, and molecular biology. Subfields include molecular biology, surgery, oncology, radiology, nuclear medicine and imaging, and cellular and molecular neuroscience.

Their research covers a range of topics, such as:

  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research
  • Glycosylation and Glycoproteins Research
  • Receptor Mechanisms and Signaling
  • Neuropeptides and Animal Physiology
  • Hypothalamic control of reproductive hormones
  • Orthopedic Infections and Treatments

The scope of this work demonstrates a blend of basic and applied biomedical research, with emphasis on receptor biology, antibody engineering, and antimicrobial strategies in clinical contexts.

Best Publications

  • Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides.

    Achim Knappik;Liming Ge;Annemarie Honegger;Peter Pack

  • Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system

    Anke Krebber;Susanne Bornhauser;Jörg Burmester;Annemarie Honegger

  • Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing.

    A.M. Honegger;T.J. Dull;S. Felder;E. Van Obberghen

  • Yet Another Numbering Scheme for Immunoglobulin Variable Domains: An Automatic Modeling and Analysis Tool

    Annemarie Honegger;Andreas Plückthun

  • Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

    M. Mohammadi;C. A. Dionne;W. Li;N. Li

  • A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

    M Mohammadi;A M Honegger;D Rotin;R Fischer

  • Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering.

    Stefan Ewert;Annemarie Honegger;Andreas Plückthun

  • Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability

    Daniela Röthlisberger;Annemarie Honegger;Andreas Plückthun

  • Biophysical properties of human antibody variable domains

    Stefan Ewert;Thomas Huber;Annemarie Honegger;Andreas Plückthun

  • Disrupting the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment.

    L Nieba;A Honegger;C Krebber;A Plückthun

  • Unbinding forces of single antibody-antigen complexes correlate with their thermal dissociation rates

    Falk Schwesinger;Robert Ros;Torsten Strunz;Dario Anselmetti

  • Antibody scFv Fragments Without Disulfide Bonds Made by Molecular Evolution

    Karl Proba;Arne Wörn;Annemarie Honegger;Andreas Plückthun

  • The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

    Christine Rothe;Stefanie Urlinger;Corinna Löhning;Josef Prassler

  • Tailoring in vitro evolution for protein affinity or stability

    Lutz Jermutus;Annemarie Honegger;Falk Schwesinger;Jozef Hanes

  • High thermal stability is essential for tumor targeting of antibody fragments: engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment.

    J Willuda;A Honegger;R Waibel;P A Schubiger

  • Selection for improved protein stability by phage display.

    Sabine Jung;Annemarie Honegger;Andreas Plückthun

  • The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system.

    J B Levy;P D Canoll;O Silvennoinen;G Barnea

  • All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.

    B L Margolis;I Lax;R Kris;M Dombalagian

  • Insulin-like growth factors I and II in fetal and adult bovine serum. Purification, primary structures, and immunological cross-reactivities.

    Annemarie Honegger;Rene E. Humbel

  • A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

    A M Honegger;D Szapary;A Schmidt;R Lyall

Frequent Co-Authors

Andreas Plückthun
Andreas Plückthun University of Zurich
Axel Ullrich
Axel Ullrich Max Planck Institute of Biochemistry
Joseph Schlessinger
Joseph Schlessinger Yale University
Moosa Mohammadi
Moosa Mohammadi New York University Langone Medical Center
Christian Cambillau
Christian Cambillau Centre national de la recherche scientifique, CNRS
Uwe Zangemeister-Wittke
Uwe Zangemeister-Wittke University of Bern
Silvia Spinelli
Silvia Spinelli Centre national de la recherche scientifique, CNRS
Tom L. Blundell
Tom L. Blundell University of Cambridge
David Baker
David Baker University of Washington
Winfried S. Wels
Winfried S. Wels Goethe University Frankfurt

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