World's Best Scientists 2026 revealed!
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Biology and Biochemistry
UK
2026

D-Index & Metrics

Chemistry

D-Index
131
Citations
73960
World Ranking
304
National Ranking
14

Biology and Biochemistry

D-Index
138
Citations
84607
World Ranking
291
National Ranking
18

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2008 - Fellow, The World Academy of Sciences
  • 1993 - Member of Academia Europaea
  • 1984 - Fellow of the Royal Society, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Tom L. Blundell is affiliated with the University of Cambridge in the United Kingdom. Their research spans multiple fields within the biological and medical sciences, with a focus on biochemistry, genetics, and molecular biology, as well as medicine.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

More specifically, they have contributed extensively to several subfields, such as:

  • Molecular Biology
  • Infectious Diseases
  • Materials Chemistry
  • Epidemiology
  • Computational Theory and Mathematics

In terms of research topics, Blundell has worked on:

  • Tuberculosis Research and Epidemiology
  • Protein Structure and Dynamics
  • Enzyme Structure and Function
  • RNA and protein synthesis mechanisms
  • Biochemical and Molecular Research
  • Computational Drug Discovery Methods
  • Mycobacterium research and diagnosis

Selected recent publications include:

  • "Utilizing graph machine learning within drug discovery and development", 2021, Briefings in Bioinformatics
  • "Stepwise pathogenic evolution of Mycobacterium abscessus", 2021, Science
  • "Dimers of DNA-PK create a stage for DNA double-strand break repair", 2020, Nature Structural & Molecular Biology
  • "Cryo-EM of NHEJ supercomplexes provides insights into DNA repair", 2021, Molecular Cell
  • "Structure-based Drug Design with Equivariant Diffusion Models", 2022, arXiv (Cornell University)

Frequent co-authors collaborating with Blundell include:

  • Chris Abell
  • Anthony G. Coyne
  • Amanda K. Chaplin
  • Sundeep Chaitanya Vedithi
  • Arian R. Jamasb

Many of their publications appear in prominent venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Progress in Biophysics and Molecular Biology
  • Briefings in Bioinformatics
  • Nucleic Acids Research
  • Computational and Structural Biotechnology Journal

Throughout their career, Blundell has received several honors including:

  • Fellow, The World Academy of Sciences (2008)
  • Member of Academia Europaea (1993)
  • Fellow of the Royal Society, United Kingdom (1984)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Comparative Protein Modelling by Satisfaction of Spatial Restraints

    Andrej Šali;Tom L. Blundell

  • pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

    Douglas E. V. Pires;Tom L. Blundell;David B. Ascher

  • FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties.

    Jiye Shi;Tom L Blundell;Kenji Mizuguchi

  • The TRANSPARENT TESTA GLABRA1 Locus, Which Regulates Trichome Differentiation and Anthocyanin Biosynthesis in Arabidopsis, Encodes a WD40 Repeat Protein

    Amanda R. Walker;Paul A. Davison;Agnese C. Bolognesi-Winfield;Celia M. James

  • Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by

    Tom Blundell;Guy Dodson;Dorothy Hodgkin;Dan Mercola

  • mCSM: predicting the effects of mutations in proteins using graph-based signatures

    Douglas E. V. Pires;David B. Ascher;Tom L. Blundell

  • Knowledge-based prediction of protein structures and the design of novel molecules.

    T. L. Blundell;B. L. Sibanda;M. J. E. Sternberg;J. M. Thornton

  • DUET: A Server for Predicting Effects of Mutations on Protein Stability Using an Integrated Computational Approach

    Douglas E.V. Pires;David B. Ascher;Tom L. Blundell

  • Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.

    Luca Pellegrini;David F. Burke;Frank von Delft;Barbara Mulloy

  • The structure of 2Zn pig insulin crystals at 1.5 A resolution.

    Edward N. Baker;Thomas L. Blundell;John F. Cutfield;Susan M. Cutfield

  • Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

    Luca Pellegrini;David S. Yu;Thomas Lo;Shubha Anand

  • High-throughput crystallography for lead discovery in drug design.

    Tom L. Blundell;Harren Jhoti;Chris Abell

  • New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

    N.Q McDonald;R Lapatto;J Murray-Rust;J Gunning

  • HOMSTRAD: A database of protein structure alignments for homologous families

    Kenji Mizuguchi;Charlotte M. Deane;Tom L. Blundell;John P. Overington

  • Structure of Rhombohedral 2 Zinc Insulin Crystals

    M. J. Adams;M. J. Adams;T. L. Blundell;E. J. Dodson;G. G. Dodson

  • Structure of pentameric human serum amyloid P component.

    Jonas Emsley;Helen E. White;Bernard P. O'Hara;Bernard P. O'Hara;Glaucius Oliva

  • Conformation of β-hairpins in protein structures: A systematic classification with applications to modelling by homology, electron density fitting and protein engineering

    Bancinyane Lynn Sibanda;Tom L. Blundell;Janet M. Thornton

  • SDM—a server for predicting effects of mutations on protein stability and malfunction

    Catherine L. Worth;Robert Preissner;Tom L. Blundell

  • X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes

    Risto Lapatto;Tom Blundell;Andrew Hemmings;John Overington

  • Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming.

    Andrej S̆ali;Tom L. Blundell

Frequent Co-Authors

Chris Abell
Chris Abell University of Cambridge
David B. Ascher
David B. Ascher University of Queensland
Ermanno Gherardi
Ermanno Gherardi University of Pavia
Narayanaswamy Srinivasan
Narayanaswamy Srinivasan Indian Institute of Science
Andrej Sali
Andrej Sali University of California, San Francisco
Alison G. Smith
Alison G. Smith University of Cambridge
Eleanor J. Dodson
Eleanor J. Dodson University of York
Guy Dodson
Guy Dodson University of York
Alessio Ciulli
Alessio Ciulli University of Dundee

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