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Chemistry

D-Index
59
Citations
13917
World Ranking
10063
National Ranking
573

Biology and Biochemistry

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61
Citations
14470
World Ranking
11283
National Ranking
867

Overview

Alessio Ciulli is affiliated with the University of Dundee in the United Kingdom. Their research primarily focuses on the intersection of biochemistry, genetics, and molecular biology, contributing extensively to the understanding of molecular mechanisms in these fields.

The scientist has contributed 171 publications in the broad area of Biochemistry, Genetics and Molecular Biology, with significant overlap into Medicine through 70 publications. Subfields of their work include molecular biology (169 publications), oncology (47 publications), hematology (17 publications), organic chemistry (5 publications), and computational theory and mathematics (2 publications).

Key topics examined in their research emphasize protein degradation and inhibitors (152 publications), ubiquitin and proteasome pathways (114 publications), and peptidase inhibition and analysis (80 publications). Other topics include multiple myeloma research and treatments (34 publications), histone deacetylase inhibitors research (20 publications), chromatin remodeling and cancer (10 publications), and click chemistry and applications (10 publications).

They have published in a range of scientific journals, with frequent venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • RSC Medicinal Chemistry
  • Nature Chemical Biology
  • Journal of the American Chemical Society

Collaborations are a notable part of the scientist's work, with frequent co-authors being:

  • Andrea Testa (18 joint publications)
  • William Farnaby (14 joint publications)
  • Conner Craigon (13 joint publications)
  • Nikolai Makukhin (11 joint publications)
  • Adam G. Bond (11 joint publications)

Representative recent papers illustrate the focal areas of their research:

  • "E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones" (2020) published in SLAS DISCOVERY
  • "Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity" (2021) published in Nature Chemical Biology
  • "A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo" (2022) published in Nature Communications
  • "Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders" (2022) published in Chemical Society Reviews
  • "Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2" (2022) published in Journal of the American Chemical Society

Best Publications

  • Structural basis of PROTAC cooperative recognition for selective protein degradation.

    Morgan S Gadd;Andrea Testa;Xavier Lucas;Kwok-Ho Chan

  • Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

    Michael Zengerle;Kwok-Ho Chan;Alessio Ciulli

  • Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction.

    Dennis L. Buckley;Inge Van Molle;Peter C. Gareiss;Hyun Seop Tae

  • BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

    William Farnaby;Manfred Koegl;Michael J. Roy;Claire Whitworth

  • Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.

    Carles Galdeano;Morgan Stuart Gadd;Pedro Soares;Salvatore Scaffidi

  • Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

    Vittoria Zoppi;Vittoria Zoppi;Scott J. Hughes;Chiara Maniaci;Andrea Testa

  • SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate.

    Michael J Roy;Sandra Winkler;Scott J Hughes;Claire Whitworth

  • E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.

    Tasuku Ishida;Alessio Ciulli

  • Small‐Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

    Dennis L. Buckley;Jeffrey L. Gustafson;Inge Van Molle;Anke G. Roth

  • Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

    Kwok Ho Chan;Michael Zengerle;Andrea Testa;Alessio Ciulli

  • A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

    Unknown

  • Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

    Chiara Maniaci;Scott J. Hughes;Andrea Testa;Wenzhang Chen

  • Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

    Julianty Frost;Carles Galdeano;Carles Galdeano;Pedro Soares;Morgan S. Gadd

  • Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.

    Emil Bulatov;Alessio Ciulli

  • Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

    Unknown

  • Structure-Based Design of a Macrocyclic PROTAC.

    Andrea Testa;Scott J. Hughes;Xavier Lucas;Xavier Lucas;Jane E. Wright

  • Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.

    Satomi Imaide;Kristin M. Riching;Nikolai Makukhin;Vesna Vetma

  • Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.

    Scott J. Hughes;Alessio Ciulli

  • Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

    Inge Van Molle;Andreas Thomann;Dennis L. Buckley;Ernest C. So

  • Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2

    Unknown

  • Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.

    Alessio Ciulli;Glyn Williams;Alison G. Smith;Tom L. Blundell

  • Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions.

    Teresa A. F. Cardote;Alessio Ciulli

  • Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

    Pedro Soares;Morgan S. Gadd;Julianty Frost;Carles Galdeano

  • Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

    Martin Philpott;Jing Yang;Tony Tumber;Oleg Fedorov

Frequent Co-Authors

Chris Abell
Chris Abell University of Cambridge
Tom L. Blundell
Tom L. Blundell University of Cambridge
Craig M. Crews
Craig M. Crews Yale University
Sonia Rocha
Sonia Rocha University of Liverpool
Panagis Filippakopoulos
Panagis Filippakopoulos Structural Genomics Consortium
Oleg Fedorov
Oleg Fedorov University of Oxford
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Alison G. Smith
Alison G. Smith University of Cambridge
Dario R. Alessi
Dario R. Alessi University of Dundee
Francesco Bertoni
Francesco Bertoni Institute of Oncology Research

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