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D-Index & Metrics

Chemistry

D-Index
107
Citations
40318
World Ranking
916
National Ranking
365

Biology and Biochemistry

D-Index
118
Citations
48885
World Ranking
701
National Ranking
445

Overview

Shaomeng Wang is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a specific focus on Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, and Immunology.

The main topics Shaomeng Wang has worked on include Academic Writing and Publishing, Protein Degradation and Inhibitors, Ubiquitin and Proteasome Pathways, Peptidase Inhibition and Analysis, Multiple Myeloma Research and Treatments, Histone Deacetylase Inhibitors Research, and Prostate Cancer Treatment and Research.

Wang's frequent co-authors include Gunda I. Georg, Craig W. Lindsley, Cynthia J. Burrows, Shu Wang, and Hyun Jae Kim.

Frequent venues for Wang's publications are Journal of Medicinal Chemistry, Cancer Research, Neoplasia, bioRxiv (Cold Spring Harbor Laboratory), and ACS Medicinal Chemistry Letters.

Recent papers authored by Wang include:

  • Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2, 2020, Proceedings of the National Academy of Sciences
  • Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment, 2020, Neoplasia
  • Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein, 2020, Journal of Medicinal Chemistry
  • Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer, 2021, Journal of Medicinal Chemistry
  • Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer, 2021, Journal of Medicinal Chemistry

Best Publications

  • Further development and validation of empirical scoring functions for structure-based binding affinity prediction

    Renxiao Wang;Luhua Lai;Shaomeng Wang

  • The PDBbind database: collection of binding affinities for protein-ligand complexes with known three-dimensional structures.

    Renxiao Wang;Xueliang Fang;Yipin Lu;Shaomeng Wang

  • Comparative evaluation of 11 scoring functions for molecular docking.

    Renxiao Wang;Yipin Lu;Shaomeng Wang

  • Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

    Irfan A. Asangani;Vijaya L. Dommeti;Xiaoju Wang;Rohit Malik

  • The PDBbind database: methodologies and updates.

    Renxiao Wang;Xueliang Fang;Yipin Lu;Chao Yie Yang

  • Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

    Ke Ding;Yipin Lu;Zaneta Nikolovska-Coleska;Guoping Wang

  • Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

    Sanjeev Shangary;Dongguang Qin;Donna McEachern;Meilan Liu

  • Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

    Ke Ding;Yipin Lu;Zaneta Nikolovska-Coleska;Su Qiu

  • Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy.

    Sanjeev Shangary;Shaomeng Wang

  • Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.

    Shunqiang Li;Dong Shen;Jieya Shao;Robert Crowder

  • Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization

    Zaneta Nikolovska-Coleska;Renxiao Wang;Xueliang Fang;Hongguang Pan

  • A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

    Hui Song;Renxiao Wang;Shaomeng Wang;Jiayuh Lin

  • Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

    Yujun Zhao;Angelo Aguilar;Denzil Bernard;Shaomeng Wang

  • A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

    Longchuan Bai;Haibin Zhou;Renqi Xu;Yujun Zhao

  • Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.

    Zaneta Nikolovska-Coleska;Liang Xu;Zengjian Hu;York Tomita

  • Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening

    Istvan J. Enyedy;Yan Ling;Kassoum Nacro;York Tomita

  • Targeting the MDM2-p53 Interaction for Cancer Therapy

    Sanjeev Shangary;Shaomeng Wang

  • Coumarin-based inhibitors of HIV integrase.

    He Zhao;Nouri Neamati;Huixiao Hong;Abhijit Mazumder

  • Computer Automated log P Calculations Based on an Extended Group Contribution Approach

    Gilles Klopman;Ju Yun Li;Shaomeng Wang;Mario Dimayuga

  • Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.

    Guoping Wang;Zaneta Nikolovska-Coleska;Chao Yie Yang;Renxiao Wang

Frequent Co-Authors

Chao Yie Yang
Chao Yie Yang University of Tennessee Health Science Center
Gunda I. Georg
Gunda I. Georg University of Minnesota
Alanna Schepartz
Alanna Schepartz University of California, Berkeley
Craig W. Lindsley
Craig W. Lindsley Vanderbilt University
Carolyn R. Bertozzi
Carolyn R. Bertozzi Stanford University
Prashant V. Kamat
Prashant V. Kamat University of Notre Dame
Marc A. Hillmyer
Marc A. Hillmyer University of Minnesota
Vincent M. Rotello
Vincent M. Rotello University of Massachusetts Amherst

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