World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
91
Citations
31218
World Ranking
1959
National Ranking
718

Research.com Recognitions

  • 1978 - Fellow of Alfred P. Sloan Foundation

Overview

Alan P. Kozikowski is affiliated with StarWise Therapeutics LLC in the United States and has focused their research primarily in Biochemistry, Genetics and Molecular Biology, as well as Medicine.

Their research subfields include:

  • Molecular Biology
  • Oncology
  • Cellular and Molecular Neuroscience
  • Infectious Diseases
  • Surgery

Kozikowski's work largely revolves around several core topics:

  • Histone Deacetylase Inhibitors Research
  • Peptidase Inhibition and Analysis
  • Protein Degradation and Inhibitors
  • Signaling Pathways in Disease
  • Hereditary Neurological Disorders
  • Receptor Mechanisms and Signaling
  • Neuropeptides and Animal Physiology

Their recent publications demonstrate a concentration on histone deacetylase 6 (HDAC6) inhibitors, including structural and functional characterizations and therapeutic applications. Notable papers include:

  • "Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor" (2020) published in ACS Medicinal Chemistry Letters
  • "HDAC6 inhibition promotes α-tubulin acetylation and ameliorates CMT2A peripheral neuropathy in mice" (2020) published in Experimental Neurology
  • "Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models" (2020) published in Journal of Medicinal Chemistry
  • "Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors" (2020) published in European Journal of Medicinal Chemistry
  • "Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model" (2021) published in Journal of Medicinal Chemistry

Frequent co-authors collaborating with Kozikowski include:

  • Sida Shen
  • Cyril Bařinka
  • Bryan L. Roth
  • J. Ptáček
  • Maurício T. Tavares

The most common publication venues in which Kozikowski's work appears are:

  • Journal of Medicinal Chemistry
  • OPAL (Open@LaTrobe) (La Trobe University)
  • UNC Libraries
  • ACS Medicinal Chemistry Letters
  • Experimental Neurology

In 1978, Alan P. Kozikowski was recognized as a Fellow of the Alfred P. Sloan Foundation. This award highlights an aspect of their professional recognition within the scientific community.

Best Publications

  • Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.

    Kyle V. Butler;Jay Kalin;Camille Brochier;Guilio Vistoli

  • THE ISOXAZOLINE ROUTE TO THE MOLECULES OF NATURE

    A. P. Kozikowski

  • Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.

    Mia L. Raves;Michal Harel;Yuan Ping Pang;Israel Silman

  • A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer.

    K. P. Maresca;S. M. Hillier;F. J. Femia;D. Keith

  • Biodistribution, Tumor Detection, and Radiation Dosimetry of 18F-DCFBC, a Low-Molecular-Weight Inhibitor of Prostate-Specific Membrane Antigen, in Patients with Metastatic Prostate Cancer

    Steve Y. Cho;Kenneth L. Gage;Ronnie C. Mease;Srinivasan Senthamizhchelvan

  • Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II: Efficacy as Analgesic Agents

    Alan P. Kozikowski;Jiazhong Zhang;Fajun Nan;Pavel A. Petukhov

  • Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: In vivo Imaging in Experimental Models of Prostate Cancer

    Catherine A. Foss;Ronnie C. Mease;Hong Fan;Yuchuan Wang

  • Structure-activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating Mycobacterium tuberculosis.

    Annamaria Lilienkampf;Jialin Mao;Baojie Wan;Yuehong Wang

  • Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase)

    Alan P. Kozikowski;Fajun Nan;Paola Conti;Jiazhong Zhang

  • Synthesis and Evaluation of Technetium-99m- and Rhenium-Labeled Inhibitors of the Prostate-Specific Membrane Antigen (PSMA)

    Sangeeta R. Banerjee;Catherine A. Foss;Mark Castanares;Ronnie C. Mease

  • N-[N-[(S)-1,3-Dicarboxypropyl]Carbamoyl]-4-[18F]Fluorobenzyl-l-Cysteine, [18F]DCFBC: A New Imaging Probe for Prostate Cancer

    Ronnie C. Mease;Crystal L. Dusich;Catherine A. Foss;Hayden T. Ravert

  • Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells.

    Edwin F. de Zoeten;Liqing Wang;Kyle Butler;Ulf H. Beier

  • Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

    Alan P. Kozikowski;Subhasish Tapadar;Doris N. Luchini;Ki Hwan Kim

  • The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

    Nichole E. LaPointe;Gerardo A. Morfini;Gerardo A. Morfini;Gustavo F. Pigino;Gustavo F. Pigino;Irina N. Gaisina

  • Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors - What Some May Have Forgotten or Would Rather Forget?

    Sida Shen;Alan P. Kozikowski

  • 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth.

    Youhong Hu;Lixin Qiao;Shaomeng Wang;Suo-bao Rong

  • Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

    Alan P. Kozikowski;Haiying Sun;John Brognard;Phillip A. Dennis

  • Methods for the Stereoselective Cis Cyanohydroxylation and Carboxyhydroxylation of Olefins

    Alan P. Kozikowski;Maciej Adamczyk

  • Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth

    Joel A. Bergman;Karrune Woan;Patricio Perez-Villarroel;Alejandro Villagra

  • Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization†

    Cyril Barinka;Youngjoo Byun;Crystal L. Dusich;Sangeeta R. Banerjee

  • Sazetidine-A, A Novel Ligand That Desensitizes α4β2 Nicotinic Acetylcholine Receptors without Activating Them

    Yingxian Xiao;Hong Fan;John L. Musachio;John L. Musachio;Zhi Liang Wei;Zhi Liang Wei

Frequent Co-Authors

Dawei Ma
Dawei Ma Chinese Academy of Sciences
Judith L. Flippen-Anderson
Judith L. Flippen-Anderson United States Naval Research Laboratory
Peter M. Blumberg
Peter M. Blumberg National Institutes of Health
Bhupendra P. Doctor
Bhupendra P. Doctor Walter Reed Army Institute of Research
Clifford George
Clifford George United States Naval Research Laboratory
Garth Powis
Garth Powis Sanford Burnham Prebys Medical Discovery Institute
Giuseppe Campiani
Giuseppe Campiani University of Siena
Stefan R. Nahorski
Stefan R. Nahorski University of Leicester
Jia Zhou
Jia Zhou The University of Texas Medical Branch at Galveston
Alan I. Faden
Alan I. Faden University of Maryland, Baltimore

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a chemistry degree in the USA opens doors to various specialized career paths, many of which offer solid salary prospects and growing demand. For those interested in healthcare and pharmaceuticals, becoming a pharmacist is a rewarding option. Insights on the pharmacist salary can help students understand the financial potential in this field and the educational requirements involved.

Alternatively, roles like pharmaceutical sales representatives combine scientific knowledge with business skills. Learning about the pharmaceutical sales rep salary provides a clearer picture of what to expect in terms of compensation and career progression.

For students fascinated by forensic applications of chemistry, pursuing an affordable online forensic science degree is an excellent way to enter this niche. Programs focused on forensic science often lead to careers as autopsy technicians or related roles in forensic labs. Understanding the autopsy tech salary and job outlook is key to evaluating this pathway's stability and growth potential.

Each of these career trajectories highlights the importance of targeted education and market awareness. Exploring these resources on pharmacist salary, pharmaceutical sales rep salary, autopsy tech salary, and cheapest online forensic science degree can help guide your decisions about online degree programs and future employment.

Best Scientists Citing Alan P. Kozikowski

Trending Scientists