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Neuroscience

D-Index
89
Citations
23975
World Ranking
1170
National Ranking
601

Overview

Daniel L. Alkon is affiliated with West Virginia University in the United States. Their research primarily spans the field of Medicine, with significant contributions in the subfields of Physiology, Pharmacology, Neurology, Psychiatry, and Mental Health. The core topics of their work focus extensively on Alzheimer's disease research and treatments, cholinesterase and neurodegenerative diseases, dementia and cognitive impairment research, as well as plant and biological electrophysiology studies.

Among their recent publications are studies addressing advanced Alzheimer's disease and cognitive deficits. Notable papers include:

  • "Advanced Alzheimer's Disease Patients Show Safe, Significant, and Persistent Benefit in 6-Month Bryostatin Trial," 2023, Journal of Alzheimer's Disease
  • "Bryostatin Placebo-Controlled Trials Indicate Cognitive Restoration Above Baseline for Advanced Alzheimer's Disease in the Absence of Memantine1," 2022, Journal of Alzheimer's Disease
  • "Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice," 2020, Scientific Reports
  • "Reply to Trewavas et al. and Calvo and Trewavas," 2020, Trends in Plant Science
  • "Alzheimer's therapeutic development: shifting neurodegeneration to neuroregeneration," 2024, Trends in Pharmacological Sciences

Their frequent co-authors include Miao-Kun Sun, Richard E. Thompson, Alan J. Tuchman, Florin V. Chirila, and Guang Xu. These collaborations have resulted in multiple papers spanning several years.

Daniel L. Alkon's research has been published in a variety of scientific venues. The most frequent publication sources are:

  • Journal of Alzheimer's Disease
  • Scientific Reports
  • Alzheimer's & Dementia
  • Trends in Plant Science
  • Trends in Pharmacological Sciences

The topics covered in their work demonstrate an integration of medical and biological sciences, including detailed investigations into neurological disorders, plant molecular biology, and electrophysiology. Their published research emphasizes neurodegeneration and neuroregeneration, particularly in the context of Alzheimer's disease.

Best Publications

  • Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats.

    Weiqin Zhao;Hui Chen;Hui Xu;Elizabeth Moore

  • Insulin and the insulin receptor in experimental models of learning and memory

    Wei-Qin Zhao;Hui Chen;Michael J. Quon;Daniel L. Alkon

  • Role of insulin and insulin receptor in learning and memory

    Unknown

  • Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice.

    René Etcheberrigaray;Mathew Tan;Ilse Dewachter;Cuno Kuipéri

  • A spatial-temporal model of cell activation.

    Daniel L. Alkon;Howard Rasmussen

  • Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.

    Etsuro Ito;Kotaro Oka;René Etcheberrigaray;Thomas J. Nelson

  • Conditioning-specific membrane changes of rabbit hippocampal neurons measured in vitro

    John F. Disterhoft;Douglas A. Coulter;Daniel L. Alkon

  • PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease.

    Daniel L. Alkon;Miao-Kun Sun;Thomas J. Nelson

  • Imaging of memory-specific changes in the distribution of protein kinase C in the hippocampus

    James L. Olds;Matthew L. Anderson;Donna L. McPhie;Latonia D. Staten

  • PKC ε Activation Prevents Synaptic Loss, Aβ Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

    Jarin Hongpaisan;Miao-Kun Sun;Daniel L. Alkon

  • Insulin receptor signaling in long-term memory consolidation following spatial learning.

    Jing-Tao Dou;Min Chen;Franck Dufour;Daniel L. Alkon

  • Memory-specific temporal profiles of gene expression in the hippocampus.

    Sebastiano Cavallaro;Velia D'Agata;Pachiappan Manickam;Franck Dufour

  • Thermal Imaging of Receptor-Activated Heat Production in Single Cells

    Ofer Zohar;Masayaki Ikeda;Hiroyuki Shinagawa;Hiroko Inoue

  • Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair.

    Thomas. J. Nelson;Miao-Kun Sun;Jarin Hongpaisan;Daniel L. Alkon

  • Classical conditioning induces long-term translocation of protein kinase C in rabbit hippocampal CA1 cells

    Barry Bank;Ann Deweer;Alan M. Kuzirian;Howard Rasmussen

  • Soluble β-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels

    René Etcheberrigaray;Etsuro Ito;Etsuro Ito;Christopher S. Kim;Daniel L. Alkon

  • Carbonic anhydrase gating of attention: memory therapy and enhancement

    Miao-Kun Sun;Daniel L Alkon

  • A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC

    Jarin Hongpaisan;Daniel L. Alkon

  • Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

    L. Gasparini;M. Racchi;G. Binetti;M. Trabucchi

  • Hippocampal lesions impair memory of short-delay conditioned eye blink in rabbits.

    Eisuke Akase;Daniel L. Alkon;John F. Disterhoft

  • Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory

    Alessia Pascale;Pavel A. Gusev;Marialaura Amadio;Tania Dottorini

  • CALCIUM RESPONSES IN FIBROBLASTS FROM ASYMPTOMATIC MEMBERS OF ALZHEIMER'S DISEASE FAMILIES

    René Etcheberrigaray;Naohide Hirashima;Linda Nee;José Prince

  • Synaptic transmission and neuronal interaction

    Wm.J. Adelman;Daniel L. Alkon

Frequent Co-Authors

Bernard G. Schreurs
Bernard G. Schreurs West Virginia University
Louis D. Matzel
Louis D. Matzel Rutgers, The State University of New Jersey
Etsuro Ito
Etsuro Ito Waseda University
Stefano Govoni
Stefano Govoni University of Pavia
Gary E. Gibson
Gary E. Gibson Cornell University
John F. Disterhoft
John F. Disterhoft Northwestern University
Giorgio A. Ascoli
Giorgio A. Ascoli George Mason University
Douglas A. Coulter
Douglas A. Coulter Children's Hospital of Philadelphia
Mortimer Mishkin
Mortimer Mishkin National Institutes of Health
Bruce A. Hay
Bruce A. Hay California Institute of Technology

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