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Biology and Biochemistry
Russia
2023

D-Index & Metrics

Neuroscience

D-Index
83
Citations
24009
World Ranking
1451
National Ranking
725

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Russia Leader Award
  • 2022 - Research.com Biology and Biochemistry in Russia Leader Award

Overview

Ilya Bezprozvanny is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research spans multiple domains within biochemistry, genetics, molecular biology, and neuroscience.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Subfields of study in which Bezprozvanny has contributed are:

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Physiology
  • Biophysics
  • Neurology

Their work covers key topics such as:

  • Neuroscience and Neuropharmacology Research
  • Alzheimer's disease research and treatments
  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Photoreceptor and optogenetics research
  • Advanced Fluorescence Microscopy Techniques
  • Ion channel regulation and function

Bezprozvanny has published papers in a range of scientific journals, with frequent contributions to:

  • International Journal of Molecular Sciences
  • Biochemical and Biophysical Research Communications
  • Journal of Evolutionary Biochemistry and Physiology
  • Neuroscience and Behavioral Physiology
  • Scientific Reports

Recent publications include:

  • "Dendritic Spines Shape Analysis-Classification or Clusterization? Perspective," 2020, Frontiers in Synaptic Neuroscience
  • "Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease," 2021, Trends in Cell Biology
  • "Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress," 2021, Neuron
  • "The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease," 2021, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • "The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains," 2021, eLife

Frequently collaborating co-authors include:

  • О. Л. Власова
  • Ekaterina Pchitskaya
  • Polina A. Egorova
  • А. И. Ерофеев
  • Anastasia Bolshakova

Bezprozvanny's research focuses on cellular mechanisms that underpin neurological functions and disorders. The focus on calcium signaling, mitochondrial function, and protein interactions often relates to neurodegenerative diseases such as Alzheimer's disease. The combination of biochemical and molecular techniques with neuroscience highlights a multidisciplinary approach.

Best Publications

  • Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum.

    Ilya Bezprozvanny;James Watras;Barbara E. Ehrlich

  • Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.

    Ilya Bezprozvanny;Mark P. Mattson

  • Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.

    Huiping Tu;Omar Nelson;Arseny Bezprozvanny;Zhengnan Wang

  • Huntingtin and Huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

    Tie Shan Tang;Huiping Tu;Edmond Y W Chan;Anton Maximov

  • Calcium signaling and neurodegenerative diseases

    Ilya Bezprozvanny

  • The pharmacology of intracellular Ca2+-release channels

    Barbara E. Ehrlich;Ed Kaftan;Svetlana Bezprozvannaya;Ilya Bezprozvanny

  • Functional impact of syntaxin on gating of N-type and Q-type calcium channels

    I. Bezprozvanny;R. H. Scheller;R. W. Tsien

  • Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

    Tie Shan Tang;Elizabeth Slow;Vitalie Lupu;Irina G. Stavrovskaya

  • Association of Neuronal Calcium Channels with Modular Adaptor Proteins

    Anton Maximov;Thomas C. Südhof;Ilya Bezprozvanny

  • Maintaining the Stability of Neural Function: A Homeostatic Hypothesis

    Graeme W Davis;Ilya Bezprozvanny

  • The dysregulation of intracellular calcium in Alzheimer disease

    Charlene B Supnet;Ilya Bezprozvanny

  • Reelin Modulates NMDA Receptor Activity in Cortical Neurons

    Ying Chen;Uwe Beffert;Mert Ertunc;Tie Shan Tang

  • Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.

    Ekaterina Pchitskaya;Elena Popugaeva;Ilya Bezprozvanny;Ilya Bezprozvanny

  • Secondary Structure of Huntingtin Amino-Terminal Region

    Mee Whi Kim;Yogarany Chelliah;Sang Woo Kim;Zbyszek Otwinowski

  • G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca2+ Channels Is Dependent on a Shank-Binding Domain

    Patricia A. Olson;Tatiana Tkatch;Salvador Hernandez-Lopez;Sasha Ulrich

  • Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

    Suya Sun;Hua Zhang;Jie Liu;Elena Popugaeva

  • Deranged neuronal calcium signaling and Huntington disease

    Ilya Bezprozvanny;Michael R. Hayden

  • Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 2

    Jing Liu;Tie Shan Tang;Huiping Tu;Huiping Tu;Omar Nelson

  • Familial Alzheimer disease–linked mutations specifically disrupt Ca2+ leak function of presenilin 1

    Omar Nelson;Huiping Tu;Tianhua Lei;Mostafa Bentahir

  • Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967).

    Ilya Bezprozvanny;R. W. Tsien

  • Synaptic Targeting of N-Type Calcium Channels in Hippocampal Neurons

    Anton Maximov;Ilya Bezprozvanny

  • Functional Properties of a New Voltage-dependent Calcium Channel α2δ Auxiliary Subunit Gene (CACNA2D2)

    Boning Gao;Yoshitaka Sekido;Anton Maximov;Mohamad Saad

  • The inositol 1,4,5-trisphosphate receptors.

    Ilya Bezprozvanny

Frequent Co-Authors

Richard W. Tsien
Richard W. Tsien New York University
Ege T. Kavalali
Ege T. Kavalali Vanderbilt University
Mary Sano
Mary Sano Icahn School of Medicine at Mount Sinai
D. James Surmeier
D. James Surmeier Northwestern University
Tatiana Tkatch
Tatiana Tkatch Northwestern University
David M. Holtzman
David M. Holtzman Washington University in St. Louis
Michelle E. Ehrlich
Michelle E. Ehrlich Icahn School of Medicine at Mount Sinai
Abraham Fisher
Abraham Fisher Israel Institute for Biological Research
David Westaway
David Westaway University of Alberta

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