World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
19815
World Ranking
4595
National Ranking
2235

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

J. Kevin Foskett is affiliated with the University of Pennsylvania in the United States. Their research focuses primarily within the broad field of Biochemistry, Genetics and Molecular Biology, with significant contributions to Molecular Biology, Cancer Research, Cell Biology, Nutrition and Dietetics, and Sensory Systems.

The scientist's work covers diverse topics including:

  • Mitochondrial Function and Pathology
  • Cancer, Hypoxia, and Metabolism
  • Ion channel regulation and function
  • ATP Synthase and ATPases Research
  • Biochemical Analysis and Sensing Techniques
  • Advanced Chemical Sensor Technologies
  • Olfactory and Sensory Function Studies

Notable recent papers include:

  • "Taste transduction and channel synapses in taste buds" (2020) published in Pflügers Archiv - European Journal of Physiology
  • "Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca 2+ transfer for survival" (2020) published in Science Signaling
  • "Calcium signaling induces a partial EMT" (2021) published in EMBO Reports
  • "Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca 2+ uptake" (2020) published in Proceedings of the National Academy of Sciences
  • "Acute Regulation of Habituation Learning via Posttranslational Palmitoylation" (2020) published in Current Biology

The scientist collaborates frequently with several colleagues, including:

  • Usha Paudel
  • Jillian Weissenrieder
  • Jason R. Pitarresi
  • Riley Payne
  • Zhongming Ma

J. Kevin Foskett has published multiple works in several key scientific venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Cell Calcium
  • American Journal of Physiology-Cell Physiology
  • Cell Reports

They were recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2013.

Best Publications

  • Inositol Trisphosphate Receptor Ca2+ Release Channels

    J. Kevin Foskett;Carl White;King-Ho Cheung;Don-On Daniel Mak

  • Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

    César Cárdenas;Russell A. Miller;Ian Smith;Thi Bui

  • MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

    Karthik Mallilankaraman;Patrick Doonan;César Cárdenas;César Cárdenas;Harish C. Chandramoorthy

  • MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

    Karthik Mallilankaraman;César Cárdenas;Patrick J. Doonan;Harish C. Chandramoorthy

  • CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

    Akiyuki Taruno;Valérie Vingtdeux;Makoto Ohmoto;Zhongming Ma

  • Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

    King-Ho Cheung;Diana Shineman;Marioly Müller;César Cárdenas

  • The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3R

    Carl White;Chi Li;Jun Yang;Nataliya B. Petrenko

  • A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk

    Ute Dreses-Werringloer;Jean Charles Lambert;Valérie Vingtdeux;Haitian Zhao

  • Inositol 1,4,5-tris-phosphate activation of inositol tris-phosphate receptor Ca2+ channel by ligand tuning of Ca2+ inhibition

    Don On Daniel Mak;Sean Mcbride;J. Kevin Foskett

  • Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction.

    Viswanathan Raghuram;Don-On Daniel Mak;J. Kevin Foskett

  • Chloride cells and the hormonal control of teleost fish osmoregulation

    J K Foskett;H A Bern;T E Machen;M Conner

  • Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca2+ release channels

    Jun Yang;Sean McBride;Don On Daniel Mak;Noga Vardi

  • Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase

    Kenneth R. Hallows;Viswanathan Raghuram;Bruce E. Kemp;Lee A. Witters

  • Subunit Stoichiometry of the Epithelial Sodium Channel

    Farhad Kosari;Shaohu Sheng;Jinqing Li;Don On D. Mak

  • Identification of the Erythrocyte Rh Blood Group Glycoprotein as a Mammalian Ammonium Transporter

    Connie M. Westhoff;Michelle Ferreri-Jacobia;Don-On Daniel Mak;J. Kevin Foskett

  • Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

    César Cárdenas;Marioly Müller;Andrew McNeal;Alenka Lovy

  • Differentiation of the Chloride Extrusion Mechanism During Seawater Adaptation of a Teleost Fish, The Cichlid Sarotherodon Mossambicus

    J. Kevin Foskett;Craig D. Logsdon;Timothy Turner;Terry E. Machen

  • Mutant (δF508) Cystic Fibrosis Transmembrane Conductance Regulator Cl− Channel Is Functional When Retained in Endoplasmic Reticulum of Mammalian Cells

    Eva A. Pasyk;J. Kevin Foskett

  • Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.

    King-Ho Cheung;Lijuan Mei;Don-On Daniel Mak;Ikuo Hayashi

  • Focal localization of the NHE-1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH

    S. Grinstein;M. Woodside;T. K. Waddell;G. P. Downey

Frequent Co-Authors

Philippe Marambaud
Philippe Marambaud Feinstein Institute for Medical Research
Peter Davies
Peter Davies University of Queensland
Muniswamy Madesh
Muniswamy Madesh The University of Texas at Austin
Ian Parker
Ian Parker University of California, Irvine
Morris J. Birnbaum
Morris J. Birnbaum Pfizer (United States)
Michael G. Tordoff
Michael G. Tordoff Monell Chemical Senses Center
Jordi Molgó
Jordi Molgó Centre national de la recherche scientifique, CNRS
Terry E. Machen
Terry E. Machen University of California, Berkeley
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center

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