Humbert De Smedt

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Best Publications

• Endoplasmic-Reticulum Calcium Depletion and Disease

  Djalila Mekahli;Geert Bultynck;Jan B. Parys;Humbert De Smedt

  495
  Citations

• Ca2+ release induced by inositol 1,4,5-trisphosphate is a steady-state phenomenon controlled by luminal Ca2+ in permeabilized cells

  Ludwig Missiaen;Humbert De Smedt;Guillaume Droogmans;Rik Casteels

  362
  Citations

• Functional specialization of calreticulin domains.

  Kimitoshi Nakamura;Anna Zuppini;Serge Arnaudeau;Jeffery Lynch

  362
  Citations

• The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

  Yi Ping Rong;Geert Bultynck;Ademuyiwa S. Aromolaran;Fei Zhong

  351
  Citations

• Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.

  Tania Szado;Veerle Vanderheyden;Jan B. Parys;Humbert De Smedt

  290
  Citations

• Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

  Yi Ping Rong;Ademuyiwa S. Aromolaran;Geert Bultynck;Fei Zhong

  281
  Citations

• A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum

  Haidar Akl;Tamara Vervloessem;Santeri Kiviluoto;Mart Bittremieux

  245
  Citations

• Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.

  Veerle Vanderheyden;Benoit Devogelaere;Ludwig Missiaen;Humbert De Smedt

  218
  Citations

• Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.

  Eva Sammels;Jan B. Parys;Ludwig Missiaen;Humbert De Smedt

  218
  Citations

• The IP(3) receptor-mitochondria connection in apoptosis and autophagy.

  Jean-Paul Decuypere;Giovanni Monaco;Geert Bultynck;Ludwig Missiaen

  216
  Citations

• Expression and function of ryanodine receptors in nonexcitable cells.

  Deborah L. Bennett;Timothy R. Cheek;Michael J. Berridge;Humbert De Smedt

  214
  Citations

• Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated.

  Jean-Paul Decuypere;Kirsten Welkenhuyzen;Tomas Luyten;Raf Ponsaerts

  207
  Citations

• Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.

  Nael Nadif Kasri;Anthony M Holmes;Geert Bultynck;Jan B Parys

  200
  Citations

• Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival☆

  Hristina Ivanova;Tim Vervliet;Ludwig Missiaen;Jan B. Parys

  195
  Citations

• Molecular and Functional Evidence for Multiple Ca2+-binding Domains in the Type 1 Inositol 1,4,5-Trisphosphate Receptor

  Ilse Sienaert;Ludwig Missiaen;Humbert De Smedt;Jan B. Parys

  194
  Citations

• Pannexins, distant relatives of the connexin family with specific cellular functions?

  Catheleyne D'hondt;Raf Ponsaerts;Humbert De Smedt;Geert Bultynck

  191
  Citations

• Caspase-3-induced Truncation of Type 1 Inositol Trisphosphate Receptor Accelerates Apoptotic Cell Death and Induces Inositol Trisphosphate-independent Calcium Release during Apoptosis

  Zerihun Assefa;Geert Bultynck;Karolina Szlufcik;Nael Nadif Kasri

  185
  Citations

• Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

  Raf Ponsaerts;Elke De Vuyst;Mauricio Retamal;Catheleyne D'hondt

  179
  Citations

• TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and golgi

  Frank Mahieu;Grzegorz Owsianik;Leen Verbert;Annelies Janssens

  176
  Citations

• Functional Characterization of Mammalian Inositol 1,4,5-Trisphosphate Receptor Isoforms

  Huiping Tu;Zhengnan Wang;Elena Nosyreva;Humbert De Smedt

  176
  Citations