D-Index & Metrics Best Publications
Humbert De Smedt

Humbert De Smedt

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 64 Citations 11,041 145 World Ranking 4423 National Ranking 81

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Amino acid
  • Biochemistry

His primary areas of investigation include Cell biology, Endoplasmic reticulum, Receptor, Inositol and Calcium signaling. His study in Cell biology is interdisciplinary in nature, drawing from both Apoptosis, Calcium-binding protein and Voltage-dependent calcium channel. Humbert De Smedt has researched Endoplasmic reticulum in several fields, including Programmed cell death and Homeostasis.

His Receptor study combines topics from a wide range of disciplines, such as Mechanism of action and Gene isoform. His studies deal with areas such as Ruthenium red, Calcium, Biophysics, Fusion protein and Binding site as well as Inositol. His biological study spans a wide range of topics, including Autophagy, Unfolded protein response, Downregulation and upregulation and Mitochondrion.

His most cited work include:

  • Endoplasmic-Reticulum Calcium Depletion and Disease (266 citations)
  • Functional specialization of calreticulin domains. (238 citations)
  • Ca2+ release induced by inositol 1,4,5-trisphosphate is a steady-state phenomenon controlled by luminal Ca2+ in permeabilized cells (233 citations)

What are the main themes of his work throughout his whole career to date?

Humbert De Smedt spends much of his time researching Cell biology, Receptor, Inositol, Biochemistry and Endoplasmic reticulum. The various areas that Humbert De Smedt examines in his Cell biology study include Inositol trisphosphate receptor and Voltage-dependent calcium channel. His work in Receptor addresses issues such as Binding site, which are connected to fields such as Plasma protein binding.

His Inositol research incorporates themes from Amino acid, Ruthenium red, Stimulation and Adenosine triphosphate. His study in Biochemistry is interdisciplinary in nature, drawing from both Biophysics and Calcium. In the field of Endoplasmic reticulum, his study on Thapsigargin overlaps with subjects such as SERCA.

He most often published in these fields:

  • Cell biology (50.26%)
  • Receptor (35.38%)
  • Inositol (33.33%)

What were the highlights of his more recent work (between 2011-2020)?

  • Cell biology (50.26%)
  • Endoplasmic reticulum (28.72%)
  • Intracellular (21.03%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cell biology, Endoplasmic reticulum, Intracellular, Apoptosis and Receptor. His Cell biology research is multidisciplinary, incorporating elements of Autophagy, Cellular homeostasis and Inositol trisphosphate receptor. His Inositol trisphosphate receptor research is multidisciplinary, relying on both Peptide sequence, Function, Binding site and Voltage-dependent calcium channel.

His Endoplasmic reticulum research integrates issues from Inositol, Peptide and Calcium signaling. The Intracellular study combines topics in areas such as Extracellular, Biophysics and Ion transporter. His Programmed cell death study, which is part of a larger body of work in Apoptosis, is frequently linked to B-cell lymphoma, bridging the gap between disciplines.

Between 2011 and 2020, his most popular works were:

  • A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum (134 citations)
  • Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival☆ (124 citations)
  • The BH4 Domain of Anti-apoptotic Bcl-XL, but Not That of the Related Bcl-2, Limits the Voltage-dependent Anion Channel 1 (VDAC1)-mediated Transfer of Pro-apoptotic Ca2+ Signals to Mitochondria (82 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Endoplasmic-Reticulum Calcium Depletion and Disease

Djalila Mekahli;Geert Bultynck;Jan B. Parys;Humbert De Smedt.
Cold Spring Harbor Perspectives in Biology (2011)

354 Citations

Ca2+ release induced by inositol 1,4,5-trisphosphate is a steady-state phenomenon controlled by luminal Ca2+ in permeabilized cells

Ludwig Missiaen;Humbert De Smedt;Guillaume Droogmans;Rik Casteels.
Nature (1992)

351 Citations

Functional specialization of calreticulin domains.

Kimitoshi Nakamura;Anna Zuppini;Serge Arnaudeau;Jeffery Lynch.
Journal of Cell Biology (2001)

309 Citations

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

Yi Ping Rong;Geert Bultynck;Ademuyiwa S. Aromolaran;Fei Zhong.
Proceedings of the National Academy of Sciences of the United States of America (2009)

297 Citations

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

Yi Ping Rong;Ademuyiwa S. Aromolaran;Geert Bultynck;Fei Zhong.
Molecular Cell (2008)

246 Citations

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.

Tania Szado;Veerle Vanderheyden;Jan B. Parys;Humbert De Smedt.
Proceedings of the National Academy of Sciences of the United States of America (2008)

245 Citations

A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum

Haidar Akl;Tamara Vervloessem;Santeri Kiviluoto;Mart Bittremieux.
Biochimica et Biophysica Acta (2014)

205 Citations

Expression and function of ryanodine receptors in nonexcitable cells.

Deborah L. Bennett;Timothy R. Cheek;Michael J. Berridge;Humbert De Smedt.
Journal of Biological Chemistry (1996)

204 Citations

Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.

Eva Sammels;Jan B. Parys;Ludwig Missiaen;Humbert De Smedt.
Cell Calcium (2010)

189 Citations

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.

Veerle Vanderheyden;Benoit Devogelaere;Ludwig Missiaen;Humbert De Smedt.
Biochimica et Biophysica Acta (2009)

185 Citations

If you think any of the details on this page are incorrect, let us know.

Contact us

Best Scientists Citing Humbert De Smedt

Geert Bultynck

Geert Bultynck

KU Leuven

Publications: 127

Jan B. Parys

Jan B. Parys

KU Leuven

Publications: 112

Katsuhiko Mikoshiba

Katsuhiko Mikoshiba

ShanghaiTech University

Publications: 75

Paolo Pinton

Paolo Pinton

University of Ferrara

Publications: 74

Luc Leybaert

Luc Leybaert

Ghent University

Publications: 62

Marek Michalak

Marek Michalak

University of Alberta

Publications: 59

Colin W. Taylor

Colin W. Taylor

University of Cambridge

Publications: 52

Martin D. Bootman

Martin D. Bootman

The Open University

Publications: 51

Ludwig Missiaen

Ludwig Missiaen

KU Leuven

Publications: 49

Frank Wuytack

Frank Wuytack

KU Leuven

Publications: 48

Carlotta Giorgi

Carlotta Giorgi

University of Ferrara

Publications: 45

David I. Yule

David I. Yule

University of Rochester

Publications: 42

Juan C. Sáez

Juan C. Sáez

University of Valparaíso

Publications: 42

Luc Raeymaekers

Luc Raeymaekers

KU Leuven

Publications: 38

Barbara E. Ehrlich

Barbara E. Ehrlich

Yale University

Publications: 36

J. Kevin Foskett

J. Kevin Foskett

University of Pennsylvania

Publications: 34

Something went wrong. Please try again later.