World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
12634
World Ranking
7582
National Ranking
3445

Overview

Rafael A. Fissore is affiliated with the University of Massachusetts Amherst in the United States. Their research focuses primarily on reproductive biology and fertility, with a strong emphasis on calcium and ion channel regulation in mammalian oocytes and embryos.

Their work covers several main fields and subfields of study, including:

  • Medicine
  • Reproductive Medicine
  • Public Health, Environmental and Occupational Health
  • Nutrition and Dietetics
  • Plant Science
  • Molecular Biology

The core topics of their research include:

  • Reproductive Biology and Fertility
  • Sperm and Testicular Function
  • Trace Elements in Health
  • Ovarian function and disorders
  • Plant Stress Responses and Tolerance
  • Magnesium in Health and Disease
  • Ion Channels and Receptors

Among their recent publications are studies addressing the dynamics of ion regulation in oocytes and fertilization processes. Notable papers include:

  • Divalent cation influx and calcium homeostasis in germinal vesicle mouse oocytes (2020), published in Cell Calcium
  • Deletion of TRPV3 and CaV3.2 T-type channels in mice undermines fertility and Ca2+ homeostasis in oocytes and eggs (2021), published in Journal of Cell Science
  • Zn2+ is essential for Ca2+ oscillations in mouse eggs (2023), published in eLife
  • Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes (2023), published in Cell Reports
  • SPERM FACTORS AND EGG ACTIVATION: ICSI and the discovery of the sperm factor and PLCZ1 (2022), published in Reproduction

The research has been disseminated across frequent publication venues including:

  • Cell Calcium
  • eLife
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Reproduction
  • Frontiers in Cell and Developmental Biology

Rafael A. Fissore has also contributed to book publications, including a title published by Frontiers Media:

  • Editors' Showcase 2022: Insights in Molecular and Cellular Reproduction (2023)

Frequent collaborators in their research include: Hiroki Akizawa, Goli Ardestani, Ingrid Carvacho, Neha Gupta, and Emily M Lopes.

Best Publications

  • Egg-to-embryo transition is driven by differential responses to Ca(2+) oscillation number.

    Tom Ducibella;Daniel Huneau;Elizabeth Angelichio;Zhe Xu

  • Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development

    Sook-Young Yoon;Teru Jellerette;Ana Maria Salicioni;Hoi Chang Lee

  • Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.

    E. Heytens;J. Parrington;K. Coward;K. Coward;C. Young

  • The roles of Ca2+, downstream protein kinases, and oscillatory signaling in regulating fertilization and the activation of development.

    Tom Ducibella;Rafael Fissore

  • Fertilization in Mammals

    Harvey M. Florman;Rafael A. Fissore

  • Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic activation.

    Teru Jellerette;Chang Li He;Hua Wu;Jan B. Parys

  • Requirement of Phospholipase Cδ4 for the Zona Pellucida-Induced Acrosome Reaction

    Kiyoko Fukami;Kazuki Nakao;Takafumi Inoue;Yuki Kataoka

  • Patterns of intracellular Ca2+ concentrations in fertilized bovine eggs.

    Rafael A. Fissore;John R. Dobrinsky;John J. Balise;Robert T. Duby

  • Potential role of mitogen-activated protein kinase during meiosis resumption in bovine oocytes.

    R. A. Fissore;Chang Li He;G. F. Vande Woude

  • Injection of a porcine sperm factor triggers calcium oscillations in mouse oocytes and bovine eggs

    Hua Wu;Chang Li He;Rafael A. Fissore

  • Mechanisms underlying oocyte activation and postovulatory ageing

    Rafael A. Fissore;Manabu Kurokawa;Jason Knott;Mao Zhang

  • Evaluation of developmental competence, nuclear and ooplasmic maturation of calf oocytes

    P. Damiani;R.A. Fissore;J.B. Cibelli;C.R. Long

  • Transgenic RNA Interference Reveals Role for Mouse Sperm Phospholipase Cζ in Triggering Ca2+ Oscillations During Fertilization

    Jason G. Knott;Manabu Kurokawa;Rafael A. Fissore;Richard M. Schultz

  • Intracellular Calcium Oscillations Signal Apoptosis Rather than Activation in In Vitro Aged Mouse Eggs

    Ana Carla Gordo;Patricia Rodrigues;Manabu Kurokawa;Teru Jellerette

  • Electrically induced calcium elevation, activation, and parthenogenetic development of bovine oocytes.

    Philippe Collas;Rafael Fissore;James M. Robl;Eddie J. Sullivan

  • Phospholipase Cδ4 is required for Ca2+ mobilization essential for acrosome reaction in sperm

    Kiyoko Fukami;Manabu Yoshida;Takafumi Inoue;Manabu Kurokawa

  • Biochemical and developmental evidence that ooplasmic maturation of prepubertal bovine oocytes is compromised.

    D.F. Salamone;P. Damiani;R.A. Fissore;J.M. Robl

  • Complete globozoospermia associated with PLCζ deficiency treated with calcium ionophore and ICSI results in pregnancy.

    S.L. Taylor;S.Y. Yoon;M.S. Morshedi;D.R. Lacey

  • Calcium oscillations and mammalian egg activation.

    Christopher Malcuit;Manabu Kurokawa;Rafael A. Fissore

  • Calcium, calcium release receptors, and meiotic resumption in bovine oocytes.

    Chang Li He;Philip Damiani;Jan B. Parys;Rafael A. Fissore

Frequent Co-Authors

Jan B. Parys
Jan B. Parys KU Leuven
James M. Robl
James M. Robl University of Massachusetts Amherst
John Parrington
John Parrington University of Oxford
Pablo E. Visconti
Pablo E. Visconti University of Massachusetts Amherst
Christophe Arnoult
Christophe Arnoult Grenoble Alpes University
Ken-ichi Sato
Ken-ichi Sato Nagoya University
Jose B. Cibelli
Jose B. Cibelli Michigan State University
Kiyoko Fukami
Kiyoko Fukami Tokyo University of Pharmacy and Life Sciences

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Students interested in Biology and Biochemistry can benefit from exploring various related online degrees and career pathways in the healthcare and life sciences sector. For those aiming to take on managerial roles in hospitals, clinics, or biotech firms, obtaining the cheapest online mba in healthcare management can be an affordable and flexible stepping stone. This can complement a science background with essential business and leadership skills.

Alternatively, technical roles in healthcare, such as medical coding and billing, are in high demand and offer remote work opportunities. It’s essential to understand your options and earning potential; for example, comparing ccs vs cpc salary can help you choose the right certification for your career goals.

Understanding the typical medical coding salary is crucial for evaluating this pathway. While there are pros and cons, you might wonder, is medical coding a good job? Weighing these factors can help you decide the best fit for your skills and ambitions as you pursue a career related to Biology or Biochemistry.

Best Scientists Citing Rafael A. Fissore

Trending Scientists

Recently Published Articles