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D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
10705
World Ranking
15076
National Ranking
1189

Overview

John Parrington is affiliated with the University of Oxford in the United Kingdom. Their research spans multiple interconnected fields, primarily within biochemistry, genetics, molecular biology, and medicine. They have contributed notably to subfields such as molecular biology, physiology, sensory systems, epidemiology, and genetics.

Their work covers a variety of main topics including:

  • Calcium signaling and nucleotide metabolism
  • CRISPR and Genetic Engineering
  • Ion Channels and Receptors
  • Pluripotent Stem Cells Research
  • Adenosine and Purinergic Signaling
  • Animal Genetics and Reproduction
  • Autophagy in Disease and Therapy

Among their recent publications are:

  • "Targeting Two-Pore Channels: Current Progress and Future Challenges," 2020, Trends in Pharmacological Sciences
  • "Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic Traits of Melanoma Cells by a Mechanism Involving the Hippo Signalling Pathway and Store-Operated Calcium Entry," 2020, Cancers
  • "Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination," 2021, The CRISPR Journal
  • "Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model," 2020, Molecular Human Reproduction
  • "Deciphering the Role of Ca2+ Signalling in Cancer Metastasis: From the Bench to the Bedside," 2021, Cancers

Frequent co-authors collaborating with Parrington include:

  • Abeer Alharbi
  • Ali Hanbashi
  • Ali Alhoshani
  • Antonella D'Amore
  • Xuhui Jin

John Parrington has published regularly in scientific venues such as:

  • Cancers
  • Cancer Research
  • Trends in Pharmacological Sciences
  • The CRISPR Journal
  • Cell Calcium

In addition to research articles, Parrington has published books with notable academic publishers, including:

  • Redesigning Life, Oxford University Press, 2020
  • Cognitive Science, WORLD SCIENTIFIC (EUROPE) eBooks, expected 2025

Best Publications

  • PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development.

    Christopher Matthew Saunders;Mark Graham Larman;John Parrington;Llewellyn J. Cox

  • NAADP mobilizes calcium from acidic organelles through two-pore channels

    Peter J. Calcraft;Margarida Ruas;Zui Pan;Xiaotong Cheng

  • Calcium oscillations in mammalian eggs triggered by a soluble sperm protein

    J Parrington;K Swann;V I Shevchenko;A K Sesay

  • Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development

    Sook-Young Yoon;Teru Jellerette;Ana Maria Salicioni;Hoi Chang Lee

  • Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.

    E. Heytens;J. Parrington;K. Coward;K. Coward;C. Young

  • Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

    Margarida Ruas;Katja Rietdorf;Abdelilah Arredouani;Lianne C. Davis

  • Oocyte activation, phospholipase C zeta and human infertility

    J Kashir;B Heindryckx;C Jones;P De Sutter

  • Gamete physiology, fertilization and egg activation in teleost fish

    K Coward;N R Bromage;O Hibbitt;J Parrington

  • TPC2 Is a Novel NAADP-sensitive Ca2+ Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

    Samantha Jane Pitt;Tim M Funnell;Mano Sitsapesan;Elisa Venturi

  • Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

    Margarida Ruas;Lianne C. Davis;Cheng Chang Chen;Anthony J. Morgan

  • Nicotinic acid adenine dinucleotide phosphate mediates Ca2+ signals and contraction in arterial smooth muscle via a two-pool mechanism.

    François-Xavier Boittin;Antony Galione;A. Mark Evans

  • Bidirectional Ca2+ signaling occurs between the endoplasmic reticulum and acidic organelles

    Anthony J. Morgan;Lianne C. Davis;Siegfried K.T.Y. Wagner;Alexander M. Lewis

  • NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

    Lianne C. Davis;Anthony J. Morgan;Ji Li Chen;Charlotte M. Snead

  • The pattern of localization of the putative oocyte activation factor, phospholipase Czeta, in uncapacitated, capacitated, and ionophore-treated human spermatozoa.

    P Grasa;K Coward;K Coward;C Young;J Parrington

  • VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling

    Annarita Favia;Marianna Desideri;Guido Gambara;Alessio D’Alessio

  • Calcium signaling via two-pore channels: local or global, that is the question.

    Michael X. Zhu;Jianjie Ma;John Parrington;Peter J. Calcraft

  • A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility

    Junaid Kashir;Michalis Konstantinidis;Celine Jones;Bernadette Lemmon

  • Expression of Inositol 1,4,5-Trisphosphate Receptors in Mouse Oocytes and Early Embryos: The Type I Isoform Is Upregulated in Oocytes and Downregulated after Fertilization

    J Parrington;S Brind;H De Smedt;R Gangeswaran

  • Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction.

    Claire Young;Patricia Grasa;Kevin Coward;Lianne C. Davis

  • PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence.

    Alaa Hachem;Jonathan Godwin;Margarida Ruas;Hoi Chang Lee

Frequent Co-Authors

Antony Galione
Antony Galione University of Oxford
Karl Swann
Karl Swann Cardiff University
Michael X. Zhu
Michael X. Zhu The University of Texas Health Science Center at Houston
Grant C. Churchill
Grant C. Churchill University of Oxford
Keith T. Jones
Keith T. Jones University of Sussex
Rafael A. Fissore
Rafael A. Fissore University of Massachusetts Amherst
Jianjie Ma
Jianjie Ma The Ohio State University
Dieter Deforce
Dieter Deforce Ghent University
Luc Leybaert
Luc Leybaert Ghent University
Gary M. Wessel
Gary M. Wessel Brown University

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