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Molecular Biology

D-Index
70
Citations
14419
World Ranking
1438
National Ranking
15

Overview

Yosef Shaul is affiliated with the Weizmann Institute of Science in Israel. Their research spans biochemistry, genetics, and molecular biology, with significant contributions also in the field of medicine.

The scientist's work covers several subfields specializing in molecular biology, infectious diseases, oncology, physiology, and immunology.

Key topics within their research portfolio include:

  • Ubiquitin and proteasome pathways
  • SARS-CoV-2 and COVID-19 research
  • RNA modifications and cancer
  • Peptidase inhibition and analysis
  • COVID-19 clinical research studies
  • CRISPR and genetic engineering
  • Cancer-related molecular pathways

Yosef Shaul's recent papers illustrate a focus on molecular mechanisms at the intersection of virology, translation regulation, and enzyme function. Notable publications include:

  • "Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism" (2022, Scientific Reports)
  • "Selective translational control of cellular and viral mRNAs by RPS3 mRNA binding" (2023, Nucleic Acids Research)
  • "NQO1 Binds and Supports SIRT1 Function" (2021, Frontiers in Pharmacology)
  • "Translation regulation of specific mRNAs by RPS26 C-terminal RNA-binding tail integrates energy metabolism and AMPK-mTOR signaling" (2023, Nucleic Acids Research)
  • "CRISPR Co-Editing Strategy for Scarless Homology-Directed Genome Editing" (2021, International Journal of Molecular Sciences)

The scientist has published multiple papers in venues such as bioRxiv (Cold Spring Harbor Laboratory), Biomolecules, Cells, Nucleic Acids Research, and Viruses, highlighting an engagement with journals that focus on molecular biology and virology.

Frequent collaborations characterize Yosef Shaul's research activity. Regular co-authors include Julia Adler, Nina Reuven, Nadav Myers, Romano Strobelt, and Shirel Steinberger, indicating an interdisciplinary and collaborative research environment.

Best Publications

  • Interaction of c-Abl and p73α and their collaboration to induce apoptosis

    Reuven Agami;Giovanni Blandino;Moshe Oren;Yosef Shaul

  • Hepatitis B virus DNA contains a glucocorticoid-responsive element.

    Ran Tur-Kaspa;Robert D. Burk;Yosef Shaul;David A. Shafritz

  • Physical interaction with Yes-associated protein enhances p73 transcriptional activity.

    Sabrina Strano;Eliana Munarriz;Mario Rossi;Luisa Castagnoli

  • Inhibition of hepatitis B virus expression and replication by RNA interference.

    Amir Shlomai;Yosef Shaul

  • A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73

    Gad Asher;Peter Tsvetkov;Chaim Kahana;Yosef Shaul

  • Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1

    Gad Asher;Joseph Lotem;Batya Cohen;Leo Sachs

  • Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.

    Dan Levy;Yaarit Adamovich;Nina Reuven;Yosef Shaul

  • NQO1 stabilizes p53 through a distinct pathway

    Gad Asher;Joseph Lotem;Rachel Kama;Leo Sachs

  • A human hepatitis B viral enhancer element.

    Y Shaul;W J Rutter;O Laub

  • Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

    Sabrina Strano;Eliana Munarriz;Mario Rossi;Barbara Cristofanelli

  • Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

    Gad Asher;Joseph Lotem;Leo Sachs;Chaim Kahana

  • 20S proteasomes and protein degradation "by default".

    Gad Asher;Nina Reuven;Yosef Shaul

  • The Yes-associated Protein 1 Stabilizes p73 by Preventing Itch-mediated Ubiquitination of p73

    D Levy;Y Adamovich;N Reuven;Y Shaul

  • The glucocorticoid receptor recognizes a specific nucleotide sequence in hepatitis B virus DNA causing increased activity of the HBV enhancer.

    Ran Tur-Kaspa;Yosef Shaul;David D. Moore;Robert D. Burk

  • 20S Proteasomal Degradation of Ornithine Decarboxylase Is Regulated by NQO1

    Gad Asher;Zippi Bercovich;Peter Tsvetkov;Yosef Shaul

  • The Crystal Structure of NAD(P)H Quinone Oxidoreductase 1 in Complex with Its Potent Inhibitor Dicoumarol

    Gad Asher;Orly Dym;Peter Tsvetkov;Julia Adler

  • The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

    Dug Keun Lee;Seok Hee Park;Youngsuk Yi;Shin Geon Choi

  • Cytokine Induction by the Hepatitis B Virus Capsid in Macrophages Is Facilitated by Membrane Heparan Sulfate and Involves TLR2

    Arik Cooper;Guy Tal;Ofer Lider;Yosef Shaul

  • Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin

    Peter Tsvetkov;Gad Asher;Veronica Reiss;Yosef Shaul

  • Hepatitis B Virus pX Targets TFIIB in Transcription Coactivation

    Izhak Haviv;Meir Shamay;Gilad Doitsh;Yosef Shaul

Frequent Co-Authors

Joseph Lotem
Joseph Lotem Weizmann Institute of Science
Leo Sachs
Leo Sachs Weizmann Institute of Science
William J. Rutter
William J. Rutter University of California, San Francisco
Giovanni Blandino
Giovanni Blandino McMaster University
Moshe Oren
Moshe Oren Weizmann Institute of Science
Reuven Agami
Reuven Agami Antoni van Leeuwenhoek Hospital
Basil S. Lewis
Basil S. Lewis Technion – Israel Institute of Technology
Sabrina Strano
Sabrina Strano McMaster University
Marius Sudol
Marius Sudol Icahn School of Medicine at Mount Sinai
Benjamin Geiger
Benjamin Geiger Weizmann Institute of Science

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