World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
12801
World Ranking
13126
National Ranking
5598

Overview

David Siegel is affiliated with the University of California, Santa Barbara in the United States. Their research spans multiple fields, primarily within medicine and biochemistry, genetics, and molecular biology. Siegel's work is notably concentrated in areas such as molecular biology, toxicology, geriatrics and gerontology, oncology, and organic chemistry.

The scientist's publications cover several main topics, including:

  • Genomics, phytochemicals, and oxidative stress
  • Bioactive Compounds and Antitumor Agents
  • Sirtuins and Resveratrol in Medicine
  • Free Radicals and Antioxidants
  • Adipose Tissue and Metabolism
  • Histone Deacetylase Inhibitors Research
  • Heat shock proteins research

Siegel has contributed to various scientific journals, with frequent publications in the following venues:

  • Redox Biology
  • Journal of the American Academy of Dermatology
  • npj Aging and Mechanisms of Disease
  • Journal of Medicinal Chemistry
  • Bone

Among recent papers authored or co-authored by Siegel are:

  • "A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation", 2020, Redox Biology
  • "The diverse functionality of NQO1 and its roles in redox control", 2021, Redox Biology
  • "NQO1 protects obese mice through improvements in glucose and lipid metabolism", 2020, npj Aging and Mechanisms of Disease
  • "Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry", 2024, Journal of Medicinal Chemistry
  • "Off-on-off-on use of imatinib in three children with fibrodysplasia ossificans progressiva", 2021, Bone

Frequent collaborators in Siegel's work include:

  • David Ross
  • Rafael de Cabo
  • Kristofer S. Fritz
  • Andrea Di Francesco
  • Michel Bernier

Siegel's scholarly output reflects a multidisciplinary approach, with integration across redox biology, metabolic regulation, and medicinal chemistry. The prominence of co-authors such as David Ross and Andrea Di Francesco indicates ongoing collaborative efforts within these specialized areas.

Best Publications

  • NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger

    David Siegel;Daniel L. Gustafson;Donna L. Dehn;Jin Yi Han

  • First direct observation of a nearly ideal graphene band structure.

    M. Sprinkle;D. Siegel;Y. Hu;J. Hicks

  • NAD(P)H:Quinone Oxidoreductase Activity Is the Principal Determinant of β-Lapachone Cytotoxicity

    John J. Pink;Sarah M. Planchon;Colleen Tagliarino;Marie E. Varnes

  • Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues.

    David Siegel;David Ross

  • Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).

    R.D. Traver;D. Siegel;H.D. Beall;Roger M. Phillips

  • Metal to insulator transition in epitaxial graphene induced by molecular doping.

    S. Y. Zhou;S. Y. Zhou;D. A. Siegel;D. A. Siegel;A. V. Fedorov;A. Lanzara;A. Lanzara

  • The Reduction of α-Tocopherolquinone by Human NAD(P)H:Quinone Oxidoreductase: The Role of α-Tocopherolhydroquinone as a Cellular Antioxidant

    David Siegel;Emiko M. Bolton;Jeanne A. Burr;Daniel C. Liebler

  • NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.

    David Siegel;Chao Yan;David Ross

  • NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics.

    David Ross;David Siegel

  • Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch.

    David Ross;David Siegel

  • Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

    David Siegel;Neil W. Gibson;Peter C. Preusch;David Ross

  • Rapid Polyubiquitination and Proteasomal Degradation of a Mutant Form of NAD(P)H:Quinone Oxidoreductase 1

    David Siegel;Adil Anwar;Shannon L. Winski;Jadwiga K. Kepa

  • The diverse functionality of NQO1 and its roles in redox control

    David Ross;David Siegel

  • DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

    D Ross;D Siegel;H Beall;A S Prakash

  • Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition.

    Wenchang Guo;Philip Reigan;David Siegel;Joseph Zirrolli

  • A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity.

    Julie L. Moran;David Siegel;David Ross

  • Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors

    D Siegel;W A Franklin;D Ross

  • Bioreductive activation of mitomycin C by DT-diaphorase.

    David Siegel;Howard Beall;Claudia Senekowitsch;Masaji Kasai

  • Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems.

    Adil Anwar;Donna Dehn;David Siegel;Jadwiga K. Kepa

  • Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.

    David Siegel;Neil W. Gibson;Peter C. Preusch;David Ross

Frequent Co-Authors

Alessandra Lanzara
Alessandra Lanzara University of California, Berkeley
Christopher J. Moody
Christopher J. Moody University of Nottingham
Shuyun Zhou
Shuyun Zhou Tsinghua University
Alexei V. Fedorov
Alexei V. Fedorov Lawrence Berkeley National Laboratory
Alex Zettl
Alex Zettl University of California, Berkeley
Kevin F. McCarty
Kevin F. McCarty Sandia National Laboratories
Michel Bernier
Michel Bernier National Institutes of Health
Andreas K. Schmid
Andreas K. Schmid Lawrence Berkeley National Laboratory
Rafael de Cabo
Rafael de Cabo National Institutes of Health
Steven G. Louie
Steven G. Louie University of California, Berkeley

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry in the USA opens doors to a wide range of related online degrees and specialized healthcare careers. Many students look for flexible pathways that blend science with hands-on healthcare experience, often beginning with associate or certificate programs.

For those interested in the diagnostic and imaging side of medicine, cheapest radiology tech programs are a smart starting point. These programs offer cost-effective options to enter a growing field in high demand.

Nutrition and wellness is another in-demand area. Earning an advanced degree from one of the leading dietetics masters programs helps graduates qualify for specialized roles as dietitians or nutrition experts.

If you are seeking a patient-facing role, accredited medical assistant programs online Michigan provide accessible entry points into healthcare with the added benefit of possible financial aid.

Medical assistants looking to advance can explore options like the cma to lpn bridge program online for further career growth and greater responsibility in clinical settings.

Best Scientists Citing David Siegel

Trending Scientists

Recently Published Articles