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D-Index
58
Citations
8346
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10898
National Ranking
2986

Overview

Ninian J. Blackburn is a researcher affiliated with Oregon Health & Science University in the United States. Their work spans multiple areas within biochemistry and chemistry, focusing on molecular biology, inorganic chemistry, and applications related to renewable energy and sustainability. Blackburn's research also touches on nutrition and dietetics as well as materials chemistry.

Their publication record includes a variety of topics, particularly emphasizing metal-catalyzed oxygenation mechanisms and the role of trace elements in health. Other significant topics covered are melanoma and MAPK pathways, CO2 reduction techniques and catalysts, porphyrin and phthalocyanine chemistry, metal complexes synthesis and properties, and chromium effects and bioremediation.

Frequent coauthors in Blackburn's work include Katherine W. Rush, Evan F. Welch, Stefanie D. Boyd, Katherine B. Alwan, and Duane D. Winkler. These collaborations reflect ongoing research engagements across related fields.

Blackburn's recent papers illustrate the scope of their research interests with publications in respected scientific journals:

  • "The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation" (2021, Journal of Biological Chemistry)
  • "Copper monooxygenase reactivity: Do consensus mechanisms accurately reflect experimental observations?" (2022, Journal of Inorganic Biochemistry)
  • "Capturing the Binuclear Copper State of Peptidylglycine Monooxygenase Using a Peptidyl-Homocysteine Lure" (2024, Journal of the American Chemical Society)
  • "Peptide Selenocysteine Substitutions Reveal Direct Substrate-Enzyme Interactions at Auxiliary Clusters in Radical S-Adenosyl-l-methionine Maturases" (2023, Journal of the American Chemical Society)
  • "New structures reveal flexible dynamics between the subdomains of peptidylglycine monooxygenase. Implications for an open to closed mechanism" (2023, Protein Science)

Blackburn's work has appeared frequently in these venues among others:

  • Journal of the American Chemical Society
  • Biochemistry
  • Dalton Transactions
  • Journal of Biological Chemistry
  • Journal of Inorganic Biochemistry

Their research contributes to core areas of biochemistry, genetics, and molecular biology with a significant emphasis on chemistry. The subfields Blackburn focuses on indicate interdisciplinary approaches involving molecular biology, inorganic chemistry, and environmental sciences.

Best Publications

  • Three-dimensional structure of the human copper transporter hCTR1

    Christopher J. De Feo;Stephen G. Aller;Stephen G. Aller;Gnana S. Siluvai;Ninian J. Blackburn

  • Peroxo-, Oxo-, and Hydroxo-Bridged Dicopper Complexes: Observation of Exogenous Hydrocarbon Substrate Oxidation

    Honorio V. Obias;Yin Lin;N. N. Murthy;Elna Pidcock

  • Metal-metal bonding in biology: EXAFS evidence for a 2.5 A copper-copper bond in the CuA center of cytochrome oxidase.

    Ninian J. Blackburn;Mary E. Barr;William H. Woodruff;John van der Ooost

  • Structural Studies of Copper(I) Complexes of Amyloid‐β Peptide Fragments: Formation of Two‐Coordinate Bis(histidine) Complexes

    Richard A. Himes;Ga Young Park;Gnana Sutha Siluvai;Ninian J. Blackburn

  • Dioxygen−copper reactivity: generation, characterization, and reactivity of a hydroperoxo−dicopper(II) complex

    Kenneth D. Karlin;Phalguni. Ghosh;Richard W. Cruse;Amjad. Farooq

  • Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone.

    Ireena Bagai;Christopher Rensing;Ninian J. Blackburn;Megan M. McEvoy

  • X-ray Absorption Spectroscopy of Metal-Histidine Coordination in Metalloproteins. Exact Simulation of the EXAFS of Tetrakis(imidazole)copper(II) Nitrate and Other Copper-Imidazole Complexes by the Use of a Multiple-Scattering Treatment

    Richard W. Strange;Ninian J. Blackburn;P. F. Knowles;S. Samar Hasnain

  • Substrate-linked Conformational Change in the Periplasmic Component of a Cu(I)/Ag(I) Efflux System

    Ireena Bagai;Wenbo Liu;Christopher Rensing;Ninian J. Blackburn

  • Unusual Cu(I)/Ag(I) coordination of Escherichia coli CusF as revealed by atomic resolution crystallography and X‐ray absorption spectroscopy

    Isabell R. Loftin;Sylvia Franke;Sylvia Franke;Ninian J. Blackburn;Megan M. McEvoy

  • The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at 1.6 A resolution.

    Pamela A. Williams;Ninian J. Blackburn;Donita Sanders;Donita Sanders;Henry Bellamy

  • Hydrogen Tunneling in Peptidylglycine α-Hydroxylating Monooxygenase

    Wilson A. Francisco;Michael J. Knapp;Ninian J. Blackburn;Judith P. Klinman

  • The catalytic core of peptidylglycine alpha-hydroxylating monooxygenase: investigation by site-directed mutagenesis, Cu X-ray absorption spectroscopy, and electron paramagnetic resonance.

    Betty A. Eipper;Andrew S. W. Quon;Richard E. Mains;John S. Boswell

  • An extended-X-ray-absorption-fine-structure study of bovine erythrocyte superoxide dismutase in aqueous solution. Direct evidence for three-co-ordinate Cu(I) in reduced enzyme.

    N J Blackburn;S S Hasnain;N Binsted;G P Diakun

  • The N-terminal metal-binding site 2 of the Wilson's Disease Protein plays a key role in the transfer of copper from Atox1

    Joel M. Walker;Dominik Huster;Martina Ralle;Clinton T. Morgan

  • X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines.

    Martina Ralle;Svetlana Lutsenko;Ninian J. Blackburn

  • Probing the Role of Axial Methionine in the Blue Copper Center of Azurin with Unnatural Amino Acids

    Steven M. Berry;Martina Ralle;Donald W. Low;Ninian J. Blackburn

  • Structural Characterization of the First Example of a Bis(μ-thiolato)dicopper(II) Complex, Relevance to Proposals for the Electron Transfer Sites in Cytochrome c Oxidase and Nitrous Oxide Reductase

    Robert P. Houser;Jason A. Halfen;Victor G. Young;Ninian J. Blackburn

  • Major changes in copper coordination accompany reduction of peptidylglycine monooxygenase: implications for electron transfer and the catalytic mechanism.

    Ninian J. Blackburn;Francis C. Rhames;Martina Ralle;Shulamit Jaron

  • Structural investigations on the coordination environment of the active-site copper centers of recombinant bifunctional peptidylglycine alpha-amidating enzyme.

    John S. Boswell;Brian J. Reedy;Raviraj Kulathila;David Merkler

  • X-ray Absorption Studies on the Mixed-Valence and Fully Reduced Forms of the Soluble CuA Domains of Cytochrome c Oxidase

    Ninian J. Blackburn;Simon De Vries;Mary E. Barr;Robert P. Houser

Frequent Co-Authors

Kenneth D. Karlin
Kenneth D. Karlin Johns Hopkins University
Richard W. Strange
Richard W. Strange University of Essex
Svetlana Lutsenko
Svetlana Lutsenko Johns Hopkins University
Yi Lu
Yi Lu University of Illinois at Urbana-Champaign
Wilfred A. van der Donk
Wilfred A. van der Donk University of Illinois at Urbana-Champaign
Judith P. Klinman
Judith P. Klinman University of California, Berkeley
S. Samar Hasnain
S. Samar Hasnain University of Liverpool
James A. Fee
James A. Fee Scripps Research Institute
Richard E. Mains
Richard E. Mains University of Connecticut Health Center
Betty A. Eipper
Betty A. Eipper University of Connecticut Health Center

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