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Pernilla Wittung-Stafshede

Pernilla Wittung-Stafshede

D-Index & Metrics

Chemistry

D-Index
60
Citations
14897
World Ranking
9603
National Ranking
134

Research.com Recognitions

  • 2001 - Fellow of Alfred P. Sloan Foundation

Overview

Pernilla Wittung-Stafshede is affiliated with Chalmers University of Technology in Sweden. Their research spans multiple fields primarily within Medicine, as well as Biochemistry, Genetics and Molecular Biology. Within these disciplines, the focus is often on Molecular Biology, Neurology, and Physiology, with additional work connected to Nutrition and Dietetics and Oncology.

The scientific topics covered in their work include:

  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Trace Elements in Health
  • Protein Structure and Dynamics
  • Neurological diseases and metabolism
  • Melanoma and MAPK Pathways
  • Computational Drug Discovery Methods

Their recent publications demonstrate a focus on neurodegenerative diseases and cellular metal homeostasis, with studies spanning from molecular to physiological levels. Selected recent papers include:

  • "A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice," 2020, published in eLife
  • "Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration," 2020, published in Proceedings of the National Academy of Sciences
  • "Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein," 2020, published in Proceedings of the National Academy of Sciences
  • "ATP7A-Regulated Enzyme Metalation and Trafficking in the Menkes Disease Puzzle," 2021, published in Biomedicines
  • "The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation," 2021, published in Journal of Biological Chemistry

Publication venues frequently featuring their work include:

  • Proceedings of the National Academy of Sciences
  • Biophysical Journal
  • ACS Chemical Neuroscience
  • Biomedicines
  • International Journal of Molecular Sciences

Collaborations have involved several frequent co-authors, indicating ongoing research partnerships and collaborative efforts. Notable collaborators include:

  • István Horváth
  • Ranjeet Kumar
  • Stéphanie Blockhuys
  • Sandra Rocha
  • Donita C. Brady

Pernilla Wittung-Stafshede has received recognition such as the Fellow of Alfred P. Sloan Foundation award in 2001.

Best Publications

  • Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

    Timothy R. Sampson;Justine W. Debelius;Taren Thron;Stefan Janssen

  • Gold Nanoparticles Can Induce the Formation of Protein-based Aggregates at Physiological pH

    Dongmao Zhang;Oara Neumann;Hui Wang;Virany M. Yuwono

  • A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

    Timothy R Sampson;Collin Challis;Neha Jain;Anastasiya Moiseyenko

  • Molecular crowding enhances native structure and stability of α/β protein flavodoxin

    Loren Stagg;Shao-Qing Zhang;Margaret S. Cheung;Pernilla Wittung-Stafshede

  • Defining the human copper proteome and analysis of its expression variation in cancers

    S. Blockhuys;E. Celauro;Camilla Hildesjö;A. Feizi

  • Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins.

    Karen L. Maxwell;David Wildes;Arash Zarrine-Afsar;Miguel A. De Los Rios

  • Crowded, cell-like environment induces shape changes in aspherical protein

    Dirar Homouz;Michael Perham;Antonios Samiotakis;Margaret S. Cheung

  • The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation

    Margery L. Evans;Erik Chorell;Jonathan D. Taylor;Jörgen Åden

  • Role of Cofactors in Protein Folding

    Pernilla Wittung-Stafshede

  • Effects of folding on metalloprotein active sites

    Jay R. Winkler;Pernilla Wittung-Stafshede;Johan Leckner;Bo G. Malmström

  • Factors defining effects of macromolecular crowding on protein stability: an in vitro/in silico case study using cytochrome c.

    Alexander Christiansen;Qian Wang;Antonios Samiotakis;Margaret S Cheung

  • Cytochrome b562 folding triggered by electron transfer: Approaching the speed limit for formation of a four-helix-bundle protein

    Pernilla Wittung-Stafshede;Jennifer C. Lee;Jay R. Winkler;Harry B. Gray

  • Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease.

    Istvan Horvath;Pernilla Wittung-Stafshede

  • Role of cofactors in metalloprotein folding.

    Corey J. Wilson;David Apiyo;Pernilla Wittung-Stafshede

  • PROTEIN FOLDING TRIGGERED BY ELECTRON TRANSFER

    Jason R. Telford;Pernilla Wittung-Stafshede;Harry B. Gray;Jay R. Winkler

  • Thermodynamic stability and folding of proteins from hyperthermophilic organisms.

    Kathryn A. Luke;Catherine L. Higgins;Pernilla Wittung-Stafshede

  • Macromolecular crowding increases structural content of folded proteins

    Michael Perham;Loren Stagg;Pernilla Wittung-Stafshede

  • Mechanisms of Protein Oligomerization : Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation

    Istvan Horvath;Christoph F. Weise;Emma K. Andersson;Erik Chorell

  • Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

    Maria E. Palm;Christoph F. Weise;Christina Lundin;Gunnar Wingsle

  • Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration

    Stéphanie Blockhuys;Xiaolu Zhang;Pernilla Wittung-Stafshede

  • The J-domain of Hsp40 couples ATP hydrolysis to substrate capture in Hsp70.

    Pernilla Wittung-Stafshede;Jesse Guidry;B Erin Horne;Samuel J Landry

Frequent Co-Authors

Harry B. Gray
Harry B. Gray California Institute of Technology
Bo G. Malmström
Bo G. Malmström University of Gothenburg
Jay R. Winkler
Jay R. Winkler California Institute of Technology
Christoph Weise
Christoph Weise Freie Universität Berlin
Bengt Nordén
Bengt Nordén Chalmers University of Technology
Jianpeng Ma
Jianpeng Ma Baylor College of Medicine
Miguel Teixeira
Miguel Teixeira Universidade Nova de Lisboa
Sarkis K. Mazmanian
Sarkis K. Mazmanian California Institute of Technology

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