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Chemistry

D-Index
43
Citations
5776
World Ranking
17332
National Ranking
690

Research.com Recognitions

  • 2019 - Member of Academia Europaea

Overview

Stefano Gianni is affiliated with Sapienza University of Rome in Italy. Their primary field of study is Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Materials Chemistry, Cell Biology, Oncology, and Immunology.

Their research work spans several key topics including Protein Structure and Dynamics, Enzyme Structure and Function, RNA and protein synthesis mechanisms, Protein Tyrosine Phosphatases, Protein Kinase Regulation and GTPase Signaling, Heat shock proteins research, and Hemoglobin structure and function.

Stefano Gianni has contributed to multiple publications, with frequent appearances in these venues:

  • International Journal of Molecular Sciences
  • Protein Science
  • Journal of Molecular Biology
  • Journal of Biological Chemistry
  • Biology Direct

Notable recent papers authored or coauthored by them include:

  • Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly, 2021, Accounts of Chemical Research
  • Templated folding of intrinsically disordered proteins, 2020, Journal of Biological Chemistry
  • Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein, 2020, Protein Science
  • SH2 Domains: Folding, Binding and Therapeutical Approaches, 2022, International Journal of Molecular Sciences
  • Supertertiary protein structure affects an allosteric network, 2020, Proceedings of the National Academy of Sciences

Frequent coauthors in their research include Angelo Toto, Francesca Malagrinò, Livia Pagano, Valeria Pennacchietti, and Awa Diop.

Stefano Gianni was recognized as a Member of Academia Europaea in 2019.

Best Publications

  • Unifying features in protein-folding mechanisms

    Stefano Gianni;Nicholas R. Guydosh;Faaizah Khan;Teresa D. Caldas

  • PDZ domains: folding and binding.

    Per Jemth;Stefano Gianni

  • Distinguishing induced fit from conformational selection

    Stefano Gianni;Stefano Gianni;Jakob Dogan;Per Jemth

  • Towards a structural biology of the hydrophobic effect in protein folding

    Carlo Camilloni;Daniela Bonetti;Angela Morrone;Rajanish Giri

  • The binding mechanisms of intrinsically disordered proteins

    Jakob Dogan;Stefano Gianni;Stefano Gianni;Per Jemth

  • Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly.

    Stefano Gianni;María Inés Freiberger;Per Jemth;Diego U. Ferreiro

  • Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation.

    Per Jemth;Stefano Gianni;Ryan Day;Bin Li

  • Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases

    Giorgio Giardina;Riccardo Montioli;Stefano Gianni;Barbara Cellini

  • Demonstration of Long-Range Interactions in a PDZ Domain by NMR, Kinetics, and Protein Engineering

    Stefano Gianni;Tine Walma;Alessandro Arcovito;Nicoletta Calosci

  • Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system

    Rajanish Giri;Angela Morrone;Angelo Toto;Maurizio Brunori

  • The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism.

    Stefano Gianni;Åke Engström;Mårten Larsson;Nicoletta Calosci

  • Coupled binding and folding of intrinsically disordered proteins : what can we learn from kinetics?

    Stefano Gianni;Jakob Dogan;Per Jemth

  • The kinetic pathway of folding of barnase.

    Faaizah Khan;Jessica I. Chuang;Stefano Gianni;Alan R. Fersht

  • Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

    Angelo Toto;Carlo Camilloni;Rajanish Giri;Rajanish Giri;Maurizio Brunori

  • Identification and characterization of protein folding intermediates.

    Stefano Gianni;Ylva Ivarsson;Per Jemth;Maurizio Brunori

  • Demonstration of a folding after binding mechanism in the recognition between the measles virus NTAIL and X domains.

    Marion Dosnon;Daniela Bonetti;Angela Morrone;Jenny Erales

  • Protein folds and protein folding

    R. Dustin Schaeffer;Valerie Daggett

  • Investigating the structural plasticity of a cytochrome P450: Three dimensional structures of P450 EryK and binding to its physiological substrate

    Carmelinda Savino;Linda Celeste Montemiglio;Giuliano Sciara;Adriana E. Miele

  • The structure of the major transition state for folding of an FF domain from experiment and simulation.

    Per Jemth;Ryan Day;Stefano Gianni;Faaizah Khan

  • A folding-after-binding mechanism describes the recognition between the transactivation domain of c-Myb and the KIX domain of the CREB-binding protein

    Stefano Gianni;Angela Morrone;Rajanish Giri;Maurizio Brunori

  • A PDZ domain recapitulates a unifying mechanism for protein folding

    Stefano Gianni;Christian D. Geierhaas;Nicoletta Calosci;Per Jemth

Frequent Co-Authors

Per Jemth
Per Jemth Uppsala University
Maurizio Brunori
Maurizio Brunori Sapienza University of Rome
Sonia Longhi
Sonia Longhi Aix-Marseille University
Åke Engström
Åke Engström Uppsala University
Carlo Camilloni
Carlo Camilloni University of Milan
Michele Vendruscolo
Michele Vendruscolo University of Cambridge
Robert M. Kacmarek
Robert M. Kacmarek Harvard University
Valerie Daggett
Valerie Daggett University of Washington
Warren M. Zapol
Warren M. Zapol Harvard University
Alan R. Fersht
Alan R. Fersht University of Cambridge

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