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D-Index & Metrics

Chemistry

D-Index
50
Citations
8488
World Ranking
14427
National Ranking
3710

Overview

Giovanna Scapin is affiliated with MSD in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and materials science. Their work integrates multiple scientific disciplines, with a strong emphasis on materials chemistry and molecular biology at the subfield level. The scientist's research also spans molecular medicine, oncology, and radiology, nuclear medicine and imaging.

The main topics covered in their research include:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Enzyme Structure and Function
  • Antibiotic Resistance in Bacteria
  • Monoclonal and Polyclonal Antibodies Research
  • Biochemical and Molecular Research
  • Phenothiazines and Benzothiazines Synthesis and Activities

The scientist has published in a range of venues, notably with multiple publications in:

  • The Cambridge Structural Database
  • Journal of Medicinal Chemistry
  • Acta Crystallographica Section A Foundations and Advances
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Communications

Recent relevant research publications by Giovanna Scapin include:

  • Small Molecule Microcrystal Electron Diffraction for the Pharmaceutical Industry-Lessons Learned From Examining Over Fifty Samples, 2021, Frontiers in Molecular Biosciences
  • Functionally Selective Signaling and Broad Metabolic Benefits by Novel Insulin Receptor Partial Agonists, 2022, Nature Communications
  • Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates, 2022, Journal of Medicinal Chemistry
  • Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction, 2021, Journal of Medicinal Chemistry
  • Cerastecins Inhibit Membrane Lipooligosaccharide Transport in Drug-Resistant Acinetobacter baumannii, 2024, Nature Microbiology

Giovanna Scapin frequently collaborates with fellow researchers, including:

  • Jessica F. Bruhn
  • Kyle W. Lucier
  • Anchi Cheng
  • Nicole Poweleit
  • Megan L. Mayer

Best Publications

  • (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

    Dooseop Kim;Liping Wang;Maria Beconi;George J. Eiermann

  • The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

    Janina C. Eads;Giovanna Scapin;Yiming Xu;Charles Grubmeyer

  • Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.

    Catherine E Fitzgerald;Sangita B Patel;Joseph W Becker;Patricia M Cameron

  • Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.

    Giovanna Scapin;Venkata P. Dandey;Zhening Zhang;Winifred Prosise

  • Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab.

    Giovanna Scapin;Xiaoyu Yang;Winifred W Prosise;Mark McCoy

  • Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein.

    Ganesaratnam K. Balendiran;Frank Schnütgen;Giovanna Scapin;Torsten Börchers

  • Three-dimensional structure of recombinant human muscle fatty acid-binding protein.

    G Zanotti;G Scapin;P Spadon;J.H. Veerkamp

  • Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution.

    G Scapin;J I Gordon;J C Sacchettini

  • Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes.

    Tesfaye Biftu;Ranabir Sinha-Roy;Ping Chen;Xiaoxia Qian

  • Structural biology and drug discovery.

    Giovanna Scapin

  • Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®.

    Timothy A. Blizzard;Helen Chen;Seongkon Kim;Jane Wu

  • (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

    Edmondson Sd;Mastracchio A;Mathvink Rj;He J

  • Structural studies on human muscle fatty acid binding protein at 1.4 å resolution: binding interactions with three C18 fatty acids

    Aideen Cm Young;Giovanna Scapin;Arno Kromminga;Sangita B Patel

  • Structural biology in drug design: selective protein kinase inhibitors

    Giovanna Scapin

  • The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity

    Giovanna Scapin;Sangita B. Patel;JeanMarie Lisnock;Joseph W. Becker

  • Refinement of the structure of Escherichia coli-derived rat intestinal fatty acid binding protein with bound oleate to 1.75-A resolution. Correlation with the structures of the apoprotein and the protein with bound palmitate.

    J.C. Sacchettini;G Scapin;D Gopaul;J.I. Gordon

  • Crystal structure of orotate phosphoribosyltransferase.

    Giovanna Scapin;Charles Grubmeyer;James C. Sacchettini

  • The structural basis for the selectivity of benzotriazole inhibitors of PTP1B

    Giovanna Scapin;Sangita B Patel;Joseph W Becker;Qingping Wang

  • Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.

    Giovanna Scapin;Sangita B Patel;Christine Chung;Jeffrey P Varnerin

  • Enzymology of bacterial lysine biosynthesis.

    Giovanna Scapin;John S. Blanchard

  • Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate.

    Giovanna Scapin;Sreelatha G. Reddy;Renjian Zheng;John S. Blanchard

Frequent Co-Authors

Ann E. Weber
Ann E. Weber MSD (United States)
Nancy A. Thornberry
Nancy A. Thornberry MSD (United States)
James C. Sacchettini
James C. Sacchettini Texas A&M University
John S. Blanchard
John S. Blanchard Albert Einstein College of Medicine
Brian P. Kennedy
Brian P. Kennedy MSD (United States)
Malcolm Maccoss
Malcolm Maccoss MSD (United States)
Dennis M. Schmatz
Dennis M. Schmatz MSD (United States)
Lawrence Shapiro
Lawrence Shapiro Columbia University
Jacques H. Veerkamp
Jacques H. Veerkamp Radboud University
Giuseppe Zanotti
Giuseppe Zanotti University of Padua

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