Brian P. Kennedy

Overview

Best Publications

• Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

  Mounib Elchebly;Paul Payette;Eva Michaliszyn;Wanda Cromlish

  2728
  Citations

• Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B

  Alan Cheng;Noriko Uetani;Paul D. Simoncic;Paul D. Simoncic;Vikas P. Chaubey

  670
  Citations

• The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor

  P Prasit;Z Wang;C Brideau;C.-C Chan

  599
  Citations

• Rofecoxib [Vioxx, MK-0966; 4-(4′-Methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A Potent and Orally Active Cyclooxygenase-2 Inhibitor. Pharmacological and Biochemical Profiles

  Chan Cc;Boyce S;Brideau C;Charleson S

  572
  Citations

• A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains

  Brian P. Kennedy;Paul Payette;John Mudgett;Peter Vadas

  479
  Citations

• oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes

  Shannan J. Ho Sui;James R. Mortimer;David J. Arenillas;Jochen Brumm

  457
  Citations

• Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.

  Sofi G Julien;Nadia Dubé;Nadia Dubé;Michelle Read;Janice Penney

  378
  Citations

• 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2

  Anthony W. Ford-Hutchinson;Brian P. Kennedy;Petpiboon Prasit;Philip J. Vickers

  313
  Citations

• Multiple Splice Variants of the Human Calcium-independent Phospholipase A2 and Their Effect on Enzyme Activity *

  Pontus K.A. Larsson;Pontus K.A. Larsson;Hans-Erik Claesson;Brian P. Kennedy

  298
  Citations

• Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.

  G P O'Neill;J A Mancini;S Kargman;J Yergey

  267
  Citations

• Protein tyrosine phosphatases: the quest for negative regulators of insulin action

  Ernest Asante-Appiah;Brian P. Kennedy

  259
  Citations

• Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity

  René L. Jacobs;Yang Zhao;Debby P.Y. Koonen;Torunn Sletten

  237
  Citations

• Protein tyrosine phosphatase: enzymatic assays.

  Jacqueline Montalibet;Kathryn I Skorey;Brian P Kennedy

  206
  Citations

• Gene Expression Profiling in Patients with Chronic Obstructive Pulmonary Disease and Lung Cancer

  I-Ming Wang;Sergey Stepaniants;Yves Boie;James R Mortimer

  188
  Citations

• Protein tyrosine phosphatase-1B in diabetes.

  Brian P Kennedy;Chidambaram Ramachandran

  187
  Citations

• The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation

  Yaël Mamane;Chi Chung Chan;Genevieve Lavallee;Nicolas Morin

  187
  Citations

• The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene.

  Pontus K. A. Larsson Forsell;Brian P. Kennedy;Hans-Erik Claesson

  184
  Citations

• Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.

  Renata M. Oballa;Liette Belair;W. Cameron Black;Kelly Bleasby

  179
  Citations

• Cloning and expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 cDNA.

  B. P. Kennedy;Chi-Chung Chan;S. A. Culp;W. A. Cromlish

  167
  Citations

• Attenuation of adhesion-dependent signaling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B.

  Alan Cheng;Gurjeet S. Bal;Brian P. Kennedy;Michel L. Tremblay

  147
  Citations